Ototoxicity of Topical Ticarcillin and Clavulanic Acid in the Chinchilla

Jakob, Tracy; Wright, Charles G.; Robinson, Karen S.; Meyerhoff, William L.

doi:10.1001/archotol.1995.01890010027006

Cited by 10 publications

(7 citation statements)

References 17 publications

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“…Most of the studies on ototoxic effects have been performed in chinchilla or guinea pig models. [14][15][16][17][18] Several studies in various animals have demonstrated hearing loss or cochlear damage due to ear drops. Various antibiotics, antifungals, and solvents penetrated the perilymph and produced hair cell loss in animals.…”

Section: Commentmentioning

confidence: 99%

Treatment of Chronic Suppurative Otitis Media With Topical Tobramycin and Dexamethasone

Alper¹,

Dohar²,

Gulhan³

et al. 2000

Arch Otolaryngol Head Neck Surg

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Section: Commentmentioning

confidence: 99%

Treatment of Chronic Suppurative Otitis Media With Topical Tobramycin and Dexamethasone

Alper¹,

Dohar²,

Gulhan³

et al. 2000

Arch Otolaryngol Head Neck Surg

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“…In all experiments in which irritating substances were used, such as propylene glycol, 7 ticarcillin, 8 outer auditory meatus skin, 9 and modified collagen, 6 the inflammatory reaction was of the utmost importance for the induction of cholesteatomas, since, according to the authors of the cited reports, it functioned as a factor inducing epithelial migration or invagination in the outer auditory meatus or in the tympanic membrane toward the middle ear.…”

Section: Introductionmentioning

confidence: 99%

A New Experimental Model of Acquired Cholesteatoma

Massuda

Oliveira

2005

The Laryngoscope

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The presence of inflammatory cells may provoke the production of cytokines (IL-1, IL-2, IL-6, IL-8) and growth factors, which, together with the latex biomembrane, which is known to contain a protein that favors vascular growth, may cause chemotactic migration of the squamous epithelium from the external auditory meatus to the middle year of the rat, causing a cholesteatoma. The induction of an experimental cholesteatoma in rats with latex and latex plus 50% propylene glycol was effective, representing an excellent experimental model. The theory of epithelial migration in the genesis of cholesteatomas was confirmed by our observations in rats. The latex induced an acute and chronic inflammatory reaction when in contact with the mucosa of the middle ear.

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“…Moreover, with prolonged use, cholesteatomas were observed at four weeks. The recommendations from Jakob et al 's () study were that ticarcillin should not be used in ototopical preparations. These findings would be in agreement with those from the current study, which also suggest that ticarcillin is an ototoxic drug.…”

Section: Discussionmentioning

confidence: 99%

“…Animal reports and case reports make up most of the data (Phillips et al 2007 ). The same is true for dogs and cats, where much of the information is based on results in guinea pigs, mice, rabbits and chinchillas or what are often anecdotal case reports (Brummett et al 1976, Federspil et al 1976, Morizono et al 1980, Galle & Venker-Van Haagen 1986, Brownlee et al 1992, Jakob et al 1995, Serin et al 2007, Jang et al 2008, Kavanagh et al 2009, Oghan et al 2011. The lack of clinical evidence, together with the lack of topical drugs licensed for canine OM, makes therapeutic decisions difficult.…”

Section: Introductionmentioning

confidence: 99%

Brainstem auditory evoked responses in 37 dogs with otitis media before and after topical therapy

Paterson¹

2017

J of Small Animal Practice

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OBJECTIVES : The objective of this study was to determine whether intra-aural administration of aqueous solutions of marbofloxacin, gentamicin, tobramycin and ticarcillin (used off-licence) was associated with changes in hearing as measured by brainstem auditory evoked responses.MATERIALS AND METHODS : Dogs diagnosed with otitis media (n=37) underwent brainstem auditory evoked response testing and then were treated for their ear disease. First, the external ear canal and middle ear were flushed with sterile saline followed by EDTA tris with 0·15% chlorhexidine. Then, a combination of aqueous antibiotic mixed with an aqueous solution of EDTA tris was instilled into the middle ear.Follow-up examinations were undertaken for each dog, and treatment was continued until there were no detected infectious organisms or inflammatory infiltrate. Brainstem auditory evoked response testing was repeated after resolution of the infection and discontinuation of therapy.RESULTS : Brainstem auditory evoked responses in dogs treated with aqueous solutions of marbofloxacin or gentamicin remained unchanged or improved after therapy of otitis media but were impaired in dogs treated with ticarcillin or tobramycin.CLINICAL SIGNIFICANCE : If off-licence use of topical antibiotics is deemed necessary in cases of otitis media, aqueous solutions of marbofloxacin and gentamicin appear to be less ototoxic than aqueous solutions of ticarcillin or tobramycin.

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Ototoxicity of Topical Ticarcillin and Clavulanic Acid in the Chinchilla

Cited by 10 publications

References 17 publications

Treatment of Chronic Suppurative Otitis Media With Topical Tobramycin and Dexamethasone

Treatment of Chronic Suppurative Otitis Media With Topical Tobramycin and Dexamethasone

A New Experimental Model of Acquired Cholesteatoma

Brainstem auditory evoked responses in 37 dogs with otitis media before and after topical therapy

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