Ototoxicity of Topical Gentamicin in the Cat

Gentamicin Tympanoclysis: Effects on the Labyrinthine Sensory Cells

“…Such toxicity is consistent with previous cat studies using a concentration of 3 mg/mL in which damage was primarily vestibular. 10 Treatment with this dilute gentamicin solution had to be continued approximately four times longer. Logically, one might have expected to have needed to continue treatment 10 times longer if the relation between concentration and total dosage was a simple inverse one.…”

“…Such toxicity is consistent with previous cat studies using a concentration of 3 mg/mL in which damage was primarily vestibular. 10 Treatment with this dilute genta-…”

The Safety Pharmacology of Auditory Function

“…Large animals would only be used for safety assessments if bioavailability is insufficient in those species listed above, the specific indication is for large animal veterinary use, and/or a study design requires a unique endpoint, i.e., large perilymph sampling volume. Common large animal species used in ototoxicity safety testing are cats (Igarashi and Oka 1988;Lenarz et al 2007;Webster et al 1971) monkeys (Carey et al 2005;Hawkins et al 1987;Yokota et al 1984), and dogs (Kelley et al 2010;Mills et al 2005;Sockalingam et al 2002).…”

Principles of Safety Pharmacology

“…Common large animal species used in ototoxicity safety testing are cats (Igarashi and Oka 1988;Lenarz et al 2007;Webster et al 1971) monkeys (Carey et al 2005;Hawkins et al 1987;Yokota et al 1984), anddogs (Kelley et al 2010;Mills et al 2005;Sockalingam et al 2002). Large animals would only be used for safety assessments if bioavailability is insufficient in those species listed above, the specific indication is for large animal veterinary use, and/or a study design requires a unique endpoint, i.e., large perilymph sampling volume.…”