Ototoxicity of Intravenous Frusemide

Lloyd‐Mostyn, R H; Lord, Ian

doi:10.1016/s0140-6736(71)91317-1

Cited by 27 publications

(5 citation statements)

References 3 publications

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“…However, both these patients were also receiving 'non-toxic' doses of aminoglycoside antibiotics concurrently. A similar mechanism has also been suggested as the cause of deafness following frusemide (Lloyd- Mostyn and Lord, 1971). Of the 26 cases, 15 had transient and 11 permanent deafness.…”

Section: Ethacrynic Acidmentioning

confidence: 73%

Diuretics

Davies

Wilson

1975

Drugs

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Despite the bewildering number of diuretics available to the physician, these drugs can be divided into 4 main groups, characterised by their site of action on sodium reabsorption in the kidney. Drugs acting on the ascending limb of the loop of Henle have a powerful but short acting diuretic effect; they include frusemide, ethacrynic acid and bumetanide. The benzothiadiazines and related compounds have a moderate diuretic action spread over a longer period, whilst the potassium-sparing diuretics, triamterene, amiloride and spironolactone, have only a weak diuretic effect but a marked ability to diminish urinary potassium excretion. The fourth group is made up of miscellaneous substances which function as vasodilator or osmotic agents. The pathogenesis of oedema formation in heart failure is outlined and a logical approach to treatment suggested. Duiretics are being increasingly used in the treatment of non-oedematous states, in particular hypertension, diabetes insipidus and hypercalciuria; their exact role in pregnancy and acute renal failure remains controversial. Side-effects can be related to their effect on electrolyte excretion and include hypokalaemia, hyponatraemia, hyperkalaemia and hyperuricaemia. The incidence of disturbed carbohydrate tolerance in previously normal individuals is low. Other less common side-effects are also discussed.

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Section: Ethacrynic Acidmentioning

confidence: 73%

Diuretics

Davies

Wilson

1975

Drugs

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“…These reversible hearing losses were greatest in the middle frequency range. Although most cases of furosemide ototoxicity have been reversible, some authors [117,118,119,121,122] have reported permanent deafness after furosemide administration. Kshirsagar et al [123] reported a case of hearing loss following 25 mg/kg of furosemide infused slowly intravenously over 4 h in a patient with nephritic syndrome.…”

Section: Resultsmentioning

confidence: 99%

Clinical Pharmacology of Furosemide in Neonates: A Review

Pacifici

2013

Pharmaceuticals

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Furosemide is the diuretic most used in newborn infants. It blocks the Na+-K+-2Cl− symporter in the thick ascending limb of the loop of Henle increasing urinary excretion of Na+ and Cl−. This article aimed to review the published data on the clinical pharmacology of furosemide in neonates to provide a critical, comprehensive, authoritative and, updated survey on the metabolism, pharmacokinetics, pharmacodynamics and side-effects of furosemide in neonates. The bibliographic search was performed using PubMed and EMBASE databases as search engines; January 2013 was the cutoff point. Furosemide half-life (t1/2) is 6 to 20-fold longer, clearance (Cl) is 1.2 to 14-fold smaller and volume of distribution (Vd) is 1.3 to 6-fold larger than the adult values. t1/2 shortens and Cl increases as the neonatal maturation proceeds. Continuous intravenous infusion of furosemide yields more controlled diuresis than the intermittent intravenous infusion. Furosemide may be administered by inhalation to infants with chronic lung disease to improve pulmonary mechanics. Furosemide stimulates prostaglandin E2 synthesis, a potent dilator of the patent ductus arteriosus, and the administration of furosemide to any preterm infants should be carefully weighed against the risk of precipitation of a symptomatic patent ductus arteriosus. Infants with low birthweight treated with chronic furosemide are at risk for the development of intra-renal calcifications.

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“…First, given that all affected individuals have both disorders (no individual in this kindred has isolated IBS or SND), it would seem likely that a single pleotropic gene is responsible for both the biochemical abnormalities and the SND. Given that these patients are metabolically indistinguishable from patients who abuse loop diuretics and that it has been well documented that furosemide administration can result in hearing loss (Vargish et al 1970;Lloyd-MostYn and Lord 1971), a common pathway responsible for these two phenotypes could be postulated. The renal tubular cells of the TALH actively maintain Na ϩ , K ϩ , and Cl Ϫ homeostasis, through the actions of the Na ϩ -K ϩ -2Cl Ϫ cotransporter in the tubular membrane and the Na ϩ -K ϩ ATPase in the basolateral membrane of the renal tubular cells.…”

Section: Discussionmentioning

confidence: 99%

Linkage of Infantile Bartter Syndrome with Sensorineural Deafness to Chromosome 1p

Brennan

Landau

Shalev

et al. 1998

The American Journal of Human Genetics

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Bartter syndrome (BS) is a family of disorders manifested by hypokalemic hypochloremic metabolic alkalosis with normotensive hyperreninemic hyperaldosteronism. We evaluated a unique, inbred Bedouin kindred in which sensorineural deafness (SND) cosegregates with an infantile variant of the BS phenotype. Using a DNA-pooling strategy, we screened the human genome and successfully demonstrated linkage of this unique syndrome to chromosome 1p31. The genes for two kidney-specific chloride channels and a sodium/hydrogen antiporter, located near this region, were excluded as candidate genes. Although the search for the disease-causing gene in this family continues, this linkage further demonstrates the genetic heterogeneity of BS. In addition, the cosegregation of these phenotypes allows us to postulate that a single genetic alteration may be responsible for the SND and the BS phenotype. The identification and characterization of this gene would lead to a better understanding of the normal physiology of the kidney and the inner ear.

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Ototoxicity of Intravenous Frusemide

Cited by 27 publications

References 3 publications

Diuretics

Diuretics

Clinical Pharmacology of Furosemide in Neonates: A Review

Linkage of Infantile Bartter Syndrome with Sensorineural Deafness to Chromosome 1p

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