Ototoxicity of Chloroquine Phosphate

Dwivedi, Gunjan; Mehra, Y. N.

doi:10.1017/s0022215100085960

Cited by 17 publications

(59 citation statements)

References 4 publications

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“…Tinnitus has also been reported concurrently with persistent hearing loss in 1 case (20). Imbalance was reported in 3 cases (14,19,20).…”

Section: Chloroquine Ototoxicitymentioning

confidence: 92%

“…Additionally, reversible chloroquine-induced cochlear injury was detectable by brainstem audiometry in 13 out of 70 patients despite normal pure tone audiogram results (18). Tinnitus has also been reported concurrently with persistent hearing loss in 1 case (20). Imbalance was reported in 3 cases (14,19,20).…”

Section: Chloroquine Ototoxicitymentioning

confidence: 97%

“…Sensorineural hearing loss after chloroquine in a 6-year old girl was partially reversible after prednisolone administration (19). However, permanent severe sensorineural hearing loss has also been reported in 2 cases (17,20). Additionally, reversible chloroquine-induced cochlear injury was detectable by brainstem audiometry in 13 out of 70 patients despite normal pure tone audiogram results (18).…”

Section: Chloroquine Ototoxicitymentioning

confidence: 98%

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Clinical Implications of Chloroquine and Hydroxychloroquine Ototoxicity for COVID-19 Treatment: A Mini-Review

Prayuenyong

Kasbekar

Baguley

2020

Front. Public Health

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At this time of the COVID-19 pandemic, potentially effective treatments are currently under urgent investigation. Benefits of chloroquine and hydroxychloroquine for the treatment of COVID-19 infection have been proposed and clinical trials are underway. Chloroquine and hydroxychloroquine, typically used for the treatment of malaria and autoimmune diseases, have been considered for off-label use in several countries. In the literature, there are reports of ototoxic effects of the drugs causing damage to the inner ear structures, which then result in hearing loss, tinnitus, and/or imbalance. This mini-review represents a summary of the findings from a systematic search regarding ototoxicity of chloroquine and hydroxychloroquine in the published literature. The characteristics of sensorineural hearing loss and/or tinnitus after chloroquine or hydroxychloroquine treatment can be temporary but reports of persistent auditory and vestibular dysfunction exist. These are not frequent, but the impact can be substantial. Additionally, abnormal cochleovestibular development in the newborn was also reported after chloroquine treatment in pregnant women. The suggested dose of chloroquine for COVID-19 infection is considerably higher than the usual dosage for malaria treatment; therefore, it is plausible that the ototoxic effects will be greater. There are potential implications from this review for survivors of COVID-19 treated with chloroquine or hydroxychloroquine. Patient reports of hearing loss, tinnitus, or imbalance should be noted. Those with troublesome hearing loss, tinnitus and/or imbalance are encouraged to be referred for hearing evaluation and interventions once they are stable. Clinical trials of chloroquine or hydroxychloroquine should also consider including audiological monitoring in the protocol.

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“…Tinnitus has also been reported concurrently with persistent hearing loss in 1 case (20). Imbalance was reported in 3 cases (14,19,20).…”

Section: Chloroquine Ototoxicitymentioning

confidence: 92%

Section: Chloroquine Ototoxicitymentioning

confidence: 97%

Section: Chloroquine Ototoxicitymentioning

confidence: 98%

See 1 more Smart Citation

Clinical Implications of Chloroquine and Hydroxychloroquine Ototoxicity for COVID-19 Treatment: A Mini-Review

Prayuenyong

Kasbekar

Baguley

2020

Front. Public Health

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“…As hearing impairment is a reported adverse effect of chloroquine (Dwivedi & Mehra, 1978: Hart & Naunton, 1976 audiometry was performed on all subjects. Pure tone audiometry in frequencies above the conventional test range has been claimed to be useful for early detection of hearing impairment induced by drugs (Jacobson et al, 1969).…”

Section: Side Effectsmentioning

confidence: 99%

Disposition of chloroquine in man after single intravenous and oral doses.

Gustafsson¹,

Walker²,

Alván³

et al. 1983

Brit J Clinical Pharma

224

188

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“…A disacusia provocada por essas drogas pode ser reversível ou irreversível, em função do tempo de administração. [18][19][20][21] No estudo realizado por Andronopoulos 8 , a perda auditiva não foi atribuída ao efeito ototóxico da hidroxicloroquina, porém é relatado na literatura que os antimaláricos provocam destruição de células ciliadas internas e externas. 18 Geralmente a corticoterapia com prednisona (1 mg/ Kg/ dia) é a primeira opção no tratamento da disacusia autoimune, e em alguns casos a melhora clínica durante o tratamento é um critério diagnóstico.…”

Section: Introductionunclassified

Perda auditiva sensorioneural no lúpus eritematoso sistêmico: relato de três casos

Cecatto

Garcia²,

Costa³

et al. 2004

Rev. Bras. Otorrinolaringol.

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Introdução: O Lúpus Eritematoso Sistêmico (LES) é uma doença sistêmica do tecido conectivo, de etiologia desconhecida, provavelmente multifatorial. Acomete principalmente o sexo feminino podendo afetar múltiplos órgãos, dentre eles o sistema auditivo. A orelha interna pode ser lesada por diversos mecanismos auto-imunes, sendo a manifestação mais freqüente a disacusia sensorioneural flutuante, geralmente bilateral, rapidamente progressiva e com boa responsividade a imunossupressores. Objetivo: O objetivo deste trabalho é relatar três casos de disacusia de etiologia auto-imune, enfocando formas de acometimento e manifestações clíni-cas, bem como correlacionando o efeito ototóxico da cloroquina droga empregada no controle do LES com a perda auditiva. Conclusão: As perdas auditivas sensorioneurais súbitas, rapidamente progressivas ou flutuantes, podem ocorrer em pacientes com doença auto-imune e devem ser sempre lembradas nos casos de disacusia sem causa aparente.

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Ototoxicity of Chloroquine Phosphate

Cited by 17 publications

References 4 publications

Clinical Implications of Chloroquine and Hydroxychloroquine Ototoxicity for COVID-19 Treatment: A Mini-Review

Clinical Implications of Chloroquine and Hydroxychloroquine Ototoxicity for COVID-19 Treatment: A Mini-Review

Disposition of chloroquine in man after single intravenous and oral doses.

Perda auditiva sensorioneural no lúpus eritematoso sistêmico: relato de três casos

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