Ototoxicity of baby oil in a chinchilla animal model

Al-Jarallah, A.; Akinpelu, Olubunmi V.; Citra, Dan; Daniel, Sam J.

doi:10.1016/j.ijporl.2012.01.018

Cited by 5 publications

(5 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After the slaughtering procedure and initial dissection, the identification of the aortic area was performed, flushing procedure with saline solution was performed and injection of the contrast substances was initiated. For 10 carcasses, a mixture of red acrylic dye 1 and latex 1 was used (3:1) for later observation of the arteries of the cranial mediastinal space and neck while for the other ten carcasses (2nd lot), 5 mL of Visipaque 320 2 (Odixanol) was injected.…”

Section: Dissectionmentioning

confidence: 99%

“…Even though initially this species was regarded with a strict economic interest (due to the fine textured fur and elegance), in the last period, the species has become an increasingly-encountered patient in veterinary clinics and hospitals as they are bred as pets. Another important aspect is the use of the species in medical research, chinchillas being an experimental model in middle otitis [10][11][12] or ototoxicity studies for certain substances [1,6,12]. Another worth-mentioning domain that focuses lately on the same species is parasitology [5,16].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anatomical and Imagistic Aspects of the Aortic Arch in Chinchilla lanigera

Martonos

Lăcătuş

Cocan

et al. 2018

Acta Scientiae. Vet.

View full text Add to dashboard Cite

Background: The investigation on the cardiocirculatory system in chinchilla has become increasingly important due to the use of the species in experimental medicine (toxicology, pathology, parasitology etc.). Even though initially this species was regarded with a strict economic interest, in the last period, chinchillas have become an increasingly-encountered patient in veterinary clinics and hospitals. Another aspect is the use of the species in medical research, as experimental model or in parasitology. The present study tackles a combined anatomical and radiological (angiographical) study to accurately describe the vascular anatomy of the initial part of the aortic arch (Arcus aortae).Materials, Methods & Results: The anatomical distribution of collaterals detached from arcus aorticus (brachiocephalic trunk and subclavian arteries) are highlighted in this paper. To do that, the classical stratigraphic anatomical investigation, followed by the radiological study with the help of the contrast substance injected into the vascular bed were used in combination. Several Chinchilla lanigera female carcasses, obtained from a private commercial farming unit in Cluj county, Romania were used for this study. Ten carcasses were used for the anatomical study, being injected into the vascular bed with a mixture of latex and acrylic dye, fixated into formaldehyde 5% and later dissected, while the other ten carcasses were injected at the level of the aortic arch with Visipaque 320 contrast substance and subjected to the angiographical procedure.The anatomical investigation was carried after an initial 5 day-fixation period, while the angiographic procedure was initiated using the TEMCO Grx-01 device and the Veterinary Digital Imaging System® as digital imaging processing software. This combined study shows the differential mode of emergence of the subclavian and carotid arteries in this species. The brachiocephalic trunk is the first large collateral branch arising from the initial part of the aortic cross while the left subclavian artery, in all studied cases, stems from this initial part of the aortic arch. The right subclavian artery arises from the terminal part of the brachiocephalic trunk, at the cranial border of the first rib. The continuation of the trunk is represented by right common carotid artery that follows the right jugular groove. The left common carotid artery emerges at the medial aspect of the first intercostal space as a collateral branch detached from the brachiocephalic trunk, in its initial sector. In respect to the collaterals emerging from the subclavian arteries, our study showed that in all studied cases, four branches arise in sequence- the internal thoracic, dorsal scapular, vertebral and superficial cervical arteries. The existence of the common trunks (internal thoracic, dorsal scapular arteries and superficial and deep cervical arteries (as described by other authors) was not confirmed on the investigated specimens.Discussion: The paper highlights some interesting facts referring to the specific morphology of the aortic arch in chinchilla, as literature data provides some divergent data. Some of the aspects noted are confirmed (the emergence of subclavian arteries) while some others are still subjects to discussion and further investigation (collateral branches of subclavian arteries). Our approach focuses also on the comparative aspects of the morphology of the branches emerging from the aortic arch. According to the available literature, the following species were used as comparison: leporids, Guinea pig, squirrel, yellow-necked mouse, Egyptian mouse, rat, armadillo, nutria, capybara, paca, fox and leopard.

show abstract

Section: Dissectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anatomical and Imagistic Aspects of the Aortic Arch in Chinchilla lanigera

Martonos

Lăcătuş

Cocan

et al. 2018

Acta Scientiae. Vet.

View full text Add to dashboard Cite

show abstract

“…After each injection, the animals were held still in an upmost anatomical position for five minutes to ensure even distribution within the tympanic cavity. The animal model used has been previously validated in our laboratory for studying the ototoxicity of ear drops [25][26][27][28].…”

Section: Application Of Oilsmentioning

confidence: 99%

Assessment of ototoxicity of tea tree oil in a chinchilla animal model

Bezdjian

Mujica‐Mota

Azzi

et al. 2014

International Journal of Pediatric Otorhinolaryngology

View full text Add to dashboard Cite

“…45 Specifically, ototoxicity can be a potential risk since topical agents can reach the middle ear through a patent tube and diffuse into the inner ear. 46 Even benign substances that are commonly used in the clinical setting to “soften” the wax, such as baby oil, have been found to cause some degree of ototoxicity in an animal model, 47 but this has not been replicated in human trials and many otolaryngologists still routinely use oils.…”

Section: Post–tympanostomy Tube Carementioning

confidence: 99%