Ototoxicity in developing mammals

Henley, Charles M.; Rybak, Leonard P.

doi:10.1016/0165-0173(94)00006-b

Cited by 91 publications

(50 citation statements)

References 173 publications

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“…An early window of heightened vulnerability to both noise and a wide variety of ototoxicants is well supported by animal studies (e.g., Pujol 1992;Bombard et al 2005;Bernard 1981;Lataye et al 2004;Rybak et al 1991;Henley and Rybak 1995;Pryor et al 1984). Cochlear targets most affected during this window include hair cells, neurons, and stria vascularis.…”

Section: Introductionmentioning

confidence: 91%

“…Those that participate in the protection demonstrated here remain to be determined. KM affects multiple organs (Henley and Rybak 1995;Rizzi and Hirose 2007;Forge and Schacht 2000), where it may also elicit protective cascades, so that systemically mediated preconditioning influences cannot presently be ruled out.…”

Section: Sub-chronic Kanamycin As a Form Of Preconditioningmentioning

confidence: 99%

“…The targets of this early magnified injury show only partial overlap: Ototoxins primarily impact hair cells and stria (Bernard 1981;Lataye et al 2004;Pryor et al 1984;Rybak et al 1991;Henley and Rybak 1995), while noise preferentially targets hair cells and neurons (Henley and Rybak 1995;Falk et al 1974;Ohlemiller et al 2000;Kujawa and Liberman 2006). The window of vulnerability also need not be the same for noise versus aminoglycosides (Henry et al 1981;Henry 1983) or even for all ototoxicants (e.g., Lataye et al 2004).…”

Section: Kanamycin In the Early Vulnerability Windowmentioning

confidence: 99%

“…Medically fragile neonates often receive antibiotics and may experience noise peaks of up to 125 dB SPL during emergency transport via aircraft (Skeoch et al 2005;Shenai 1977;Buckland et al 2003). This practice has remained, even though human neonates may be particularly susceptible to noise, ototoxins, and their combination (Henley and Rybak 1995;Bernard 1981;Li and Steyger 2009). Presently, the risk of noise-induced permanent threshold shifts (NIPTS) to human infants is largely uncharacterized.…”

Section: Introductionmentioning

confidence: 99%

“…However, Brummett et al (1992) identified a synergistic effect between subclinical doses of white noise (as low as 75 dBA) and kanamycin (300 mg/kg) on hair cell loss in adult guinea pigs. It has remained unclear to date whether such synergy extends to neonates or is perhaps even more pronounced in neonates (Humes 1984;Henley and Rybak 1995;Li and Steyger 2009).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Protection against Noise-Induced Hearing Loss in Young CBA/J Mice by Low-Dose Kanamycin

Fernandez

Ohlemiller

Gagnon

et al. 2010

JARO

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Animal studies indicate that a combination of kanamycin (KM) and noise produces a synergistic effect, whereby the threshold shift from the combination is greater than the sum of the shifts caused by either agent alone. Most such studies have focused on adult animals, and it has remained unclear whether younger, presumably more susceptible, animals show an even greater synergistic effect. The present study tested the hypothesis that young CBA/J mice receiving a low dose of KM (300 mg/kg, 2×/day, s.c.) from 20 to 30 days post-gestational age followed by brief noise exposure (110 dB SPL; 4-45 kHz, 30 s) would show greater noise-induced permanent threshold shifts (NIPTS) than mice receiving either treatment alone. Noise exposure produced 30-40 dB of NIPTS and moderate hair cell loss in young saline-treated mice. KM alone at this dose had no effect on thresholds. Surprisingly, mice receiving KM plus noise were protected from NIPTS, showing ABR thresholds not significantly different from unexposed controls. Mice receiving KM prior to noise exposure also showed significantly less outer hair cell loss than saline-treated mice. Additional experiments indicated protection by KM when the noise was applied either 24 or 48 h after the last KM injection. Our results demonstrate a powerful protective effect of subchronic low-dose kanamycin against NIPTS in young CBA/J mice. Repeated kanamycin exposure may establish a preconditioned protective state, the molecular bases of which remain to be determined.

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Section: Introductionmentioning

confidence: 91%

Section: Sub-chronic Kanamycin As a Form Of Preconditioningmentioning

confidence: 99%