Ototoxicity effects of low exposure to solvent mixture among paint manufacturing workers

Juárez-Pérez, Cuauhtémoc Arturo; Torres-Valenzuela, Arturo; Haro-García, Luis; Borja-Aburto, Víctor Hugo; Aguilar-Madrid, Guadalupe

doi:10.3109/14992027.2014.888597

Cited by 18 publications

(18 citation statements)

References 20 publications

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“…Therefore, the ABR findings obtained in the present study suggest that the workers exposed to gasoline have auditory nerve dysfunction, as well as central auditory nervous system dysfunction involving brainstem. Dysfunction involving the auditory pathway in brainstem was also reported in a study of gasoline station workers as well as in workers exposed to solvents (Abbate et al 1993;Vrca et al 1996;Prasher et al 2005;Gopal 2008;Ju arez-P erez et al 2014;Fuente, McPherson and Cardemil 2013).…”

Section: Auditory-evoked Potentialsmentioning

confidence: 61%

“…Significantly longer ABR latencies for workers exposed to solvents have been observed (Abbate et al 1993;Vrca et al 1996;Fuente, McPherson, and Cardemil 2013;Ju arez-P erez et al 2014) but not always for the same waves. The mean latencies of waves I, III and V (Abbate et al 1993;Vrca et al 1996), I-III, III-V and I-V IPL (Abbate et al 1993), and III-IV IPL (Vrca et al 1996) were significantly longer for the exposed group than for the CG.…”

Section: Auditory-evoked Potentialsmentioning

confidence: 82%

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Auditory system dysfunction in Brazilian gasoline station workers

Roggia

França²,

Morata

et al. 2019

International Journal of Audiology

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Objective: To examine the auditory system of Brazilian gasoline station workers using an extensive audiological test battery. Design: This was a cross-sectional study. The audiological evaluation included a questionnaire, pure-tone audiometry, acoustic immittance tests, transient-evoked otoacoustic emissions (TEOAEs), distortion product otoacoustic emissions (DPOAEs), auditory brainstem response (ABR) and P300 auditoryevoked potentials. Study sample: A total of 77 Brazilian gasoline station workers were evaluated, and their results were compared with those of 36 participants who were not exposed to chemicals or noise at work. The gasoline station employees worked in 18 different gas stations, and the noise area measurements from all gas stations revealed time-weighted averages below 85 dBA. Results: Of the 77 gasoline station workers evaluated, 67.5% had audiometric results within the normal range, but 59.7% reported difficulties in communication in noisy places. Gasoline station workers showed significantly poorer results than non-exposed control participants in one or more conditions of each of the audiological tests used, except P300. Conclusions: The results suggest that the gasoline station workers have both peripheral and central auditory dysfunctions that could be partly explained by their exposure to gasoline.

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Section: Auditory-evoked Potentialsmentioning

confidence: 61%

Section: Auditory-evoked Potentialsmentioning

confidence: 82%

Auditory system dysfunction in Brazilian gasoline station workers

Roggia

França²,

Morata

et al. 2019

International Journal of Audiology

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“…[2] Although solvent mixture concentrations and noise levels were low, a study was demonstrated that there might be a concurrent ototoxicity and neurotoxicity condition. [26] In contrast, Sliwinska-Kowalska et al demonstrated that workers exposed to solvents at moderate concentrations had a raised risk of hearing impairment, but found no relationship between hearing impairment and the concentrations of the solvent. [27] The inconsistency between studies may be caused by the type and concentration of the solvent or mixture under study.…”

Section: Discussionmentioning

confidence: 90%

A comparison of the effects of solvent and noise exposure on hearing, together and separately

et al. 2014

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The objective of the present study was to assess the effects of occupational exposure to noise and organic solvents on hearing loss in bus and truck plant workers. Our case control study contained 469 workers from a bus and truck plant divided into three groups. The first group contained workers exposed to only noise; the second group contained workers exposed to both noise and mixture solvents at a permissible level; and the third group included workers exposed to permissible levels of solvents. The control group (Group 4) included 119 individuals selected randomly, persons who were not exposed to noise and solvents. These groups were compared in terms of each individual's frequency hearing loss in both ears. Our study demonstrates that combined exposure to mixed solvents and noise can exacerbate hearing loss in workers. Hence, a suitable hearing protection program is advised that would contain short-interval audiometric examinations and efficient hearing protectors.

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“…The human auditory system is vulnerable to the toxic effects of some VOCs, even at concentrations below recommended occupational exposure limits (OELs) (Juárez-Pérez et al 2014;Morata et al 2002). One reason for this may be because ototoxicity is rarely cited in the determination of the American Conference of Governmental Industrial Hygienists (ACGIH) occupational exposure limit (OEL); currently this is so for only one VOC, ethylbenzene (ACGIH 2017).…”

Section: Introductionmentioning

confidence: 99%

Inhalation exposure to volatile organic compounds in the printing industry

Alabdulhadi

Ramadan

Devey

et al. 2019

Journal of the Air & Waste Management Association

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This study reports on the occupational inhalation exposure to VOCs of workers in the Kuwaiti printing industry. Using the evacuated canister methodology, we targeted 72 VOCs in three printeries and compared the concentrations to previous reports and relevant occupational exposure levels (OELs). We found that recent efforts in the printing industry to reduce VOC usage had been successful, as concentrations of key hazardous VOCs were substantially lower than anticipated. On the other hand, nearly all target VOCs were found. Non-production areas were sampled along with the offset printing areas, another strength of this study, and revealed exposures to hazardous VOCs among administers and digital printer and CTP operators. Exposure to ototoxic VOCs amounted to 1-3% of the OEL, consisting mostly of ethylbenzene, which was likely in use in two of the study printeries. Exposure to carcinogenic or probably carcinogenic VOCs was 15-20% of the OEL at four locations across the three printeries, consisting mostly of vinyl chloride and benzyl chloride. Vinyl chloride VOC was partially sourced from outdoors, but was also likely used inside the study printeries. Interestingly, concentrations of vinyl chloride were similar in most sampling locations to that of CFC-114, a CFC banned by the Montreal Protocol and not commonly used as a refrigerant. This unexpected finding suggests further study is warranted to identify the use of these VOCs in printeries. Exposure to hazardous VOCs up to nearly 50% of the OEL, consisting largely of bromoform and vinyl chloride. Bromoform was found in all the study printeries, sourced partially from outdoor air. The higher concentrations found inside the study printeries likely resulted from the use of the desalinated water for washing. This finding raises of emissions from sources other than blanket washes, and inks, etc. adding to the total VOC load in printery indoor air. Implications: Results from this study indicate that efforts to reduce worker exposure to VOCs particularly dangerous to human health in recent years have been successful, but there is still much to be done to protect workers. Exposures to ototoxic and carcinogenic VOCs were identified, among both production and non-production workers. Unexpected findings included the apparent use in printing activities of the carcinogen vinyl chloride and CFC-114, banned under the Montreal Protocol. Observed lapses in safety procedures included failure to utilize ventilation systems and closing doors between work areas, indicating management and worker education should remain a priority.

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Ototoxicity effects of low exposure to solvent mixture among paint manufacturing workers

Cited by 18 publications

References 20 publications

Auditory system dysfunction in Brazilian gasoline station workers

Auditory system dysfunction in Brazilian gasoline station workers

A comparison of the effects of solvent and noise exposure on hearing, together and separately

Inhalation exposure to volatile organic compounds in the printing industry

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