Ototoxicity and noise trauma: Electron transfer, reactive oxygen species, cell signaling, electrical effects, and protection by antioxidants: Practical medical aspects

Kovacic, Peter; Somanathan, Ratnasamy

doi:10.1016/j.mehy.2007.06.045

Cited by 61 publications

(33 citation statements)

References 113 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, some otoprotectants may be able to rescue damaged cells once injury has occurred, thereby minimizing hearing loss. There have been numerous studies of various compounds used to protect hearing loss, ranging from antioxidants that scavenge free radicals to agents that increase blood flow and drugs that block cell-death-pathway signaling factors [69][70][71]. Despite the potential these investigations bring for protection from hearing damage, the translation of animal studies of otoprotectants to clinical treatment has been limited.…”

Section: Preventionmentioning

confidence: 99%

Auditory and vestibular dysfunction associated with blast-related traumatic brain injury

Fausti¹,

Wilmington²,

Gallun³

et al. 2009

JRRD

186

117

View full text Add to dashboard Cite

Abstract-The dramatic escalation of blast exposure in military deployments has created an unprecedented amount of traumatic brain injury (TBI) and associated auditory impairment. Auditory dysfunction has become the most prevalent individual service-connected disability, with compensation totaling more than 1 billion dollars annually. Impairment due to blast can include peripheral hearing loss, central auditory processing deficits, vestibular impairment, and tinnitus. These deficits are particularly challenging in the TBI population, as symptoms can be mistaken for posttraumatic stress disorder, mentalhealth issues, and cognitive deficits. In addition, comorbid factors such as attention, cognition, neuronal loss, noise toxicity, etc., can confound assessment, causing misdiagnosis. Furthermore, some auditory impairments, such as sensorineural hearing loss, will continue to progress with age, unlike many other injuries. In the TBI population, significant clinical challenges are the accurate differentiation of auditory and vestibular impairments from multiple, many times overlapping, symptoms and the development of multidisciplinary rehabilitation strategies to improve treatment outcomes and quality of life for these patients.

show abstract

Section: Preventionmentioning

confidence: 99%

Auditory and vestibular dysfunction associated with blast-related traumatic brain injury

Fausti¹,

Wilmington²,

Gallun³

et al. 2009

JRRD

186

117

View full text Add to dashboard Cite

show abstract

“…This iron-gentamicin complex enhances iron-catalyzed oxidations and directly promotes formation of reactive oxygen species (ROS) [11,12]. ROS have been detected in the sensory epithelium after aminoglycoside administration [13] and found to induce molecular pathways responsible for disruption of the survival of hair cells and spiral ganglion neurons in the auditory portion of the inner ear [14,15]. The contribution of neurotrophic growth factors in preventing aminoglycosides ototoxicity suggests involvement of the auditory nerve [16].…”

Section: Introductionmentioning

confidence: 99%

Neurotrophic and antioxidant effects of silymarin comparable to 4-methylcatechol in protection against gentamicin-induced ototoxicity in guinea pigs

Draz

Abdin

Sarhan

et al. 2015

Pharmacological Reports

View full text Add to dashboard Cite

show abstract

“…In the medical community, increasing attention is being given to prevention based on health measures such as diet, exercise, mental state and avoidance of drug abuse [210]. Because of the mechanisms of ototoxicity, the use of antioxidant therapy in inner ear toxicity is particularly relevant.…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress in the Cochlea: An Update

Poirrier

Pincemaïl

Ackerveken³

et al. 2010

CMC

134

View full text Add to dashboard Cite

This paper will focus on understanding the role and action of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the molecular and biochemical pathways responsible for the regulation of the survival of hair cells and spiral ganglion neurons in the auditory portion of the inner ear. The pivotal role of ROS/RNS in ototoxicity makes them potentially valuable candidates for effective otoprotective strategies. In this review, we describe the major characteristics of ROS/RNS and the different oxidative processes observed during ototoxic cascades. At each step, we discuss their potential as therapeutic targets because an increasing number of compounds that modulate ROS/RNS processing or targets are being identified.

show abstract

Ototoxicity and noise trauma: Electron transfer, reactive oxygen species, cell signaling, electrical effects, and protection by antioxidants: Practical medical aspects

Cited by 61 publications

References 113 publications

Auditory and vestibular dysfunction associated with blast-related traumatic brain injury

Auditory and vestibular dysfunction associated with blast-related traumatic brain injury

Neurotrophic and antioxidant effects of silymarin comparable to 4-methylcatechol in protection against gentamicin-induced ototoxicity in guinea pigs

Oxidative Stress in the Cochlea: An Update

Contact Info

Product

Resources

About