Otosclerosis: A local manifestation of a generalized connective tissue disorder?

Thalmann, Isolde; Thallinger, Gertraud; Thalmann, Ruediger

doi:10.1016/s0196-0709(87)80049-2

Cited by 26 publications

(2 citation statements)

References 29 publications

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“…The more frequent response of the SR one month after surgery in patients that had a low curve A registered by tympanometry, can only be explained by the hypothesis that claims otosclerosis to be a local manifestation of the generalized disease of the connective tissue. 8,9 Therefore, patients with a low A curve have not yet had the stapedial muscle damaged to the extent that it would fail to contract when the ear is exposed to strong acoustic stimuli.…”

Section: Discussionmentioning

confidence: 99%

Does it make sense to preserve the stapedial muscle during surgical treatment for otosclerosis?

Gros

Žargi²,

Vatovec³

2000

J. Laryngol. Otol.

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Our study aimed to show whether it is useful to preserve the stapedial muscle during the surgical treatment of otosclerosis. The study was carried out on 67 patients with tympanoscopic evidence of otosclerosis. In group A (34 patients) the stapedial muscle was intra-operatively preserved as follows: the stapedial suprastructure with preserved muscle tendon was transpositioned onto the longer arm of the incus and secured with a wire loop. The mean uncomfortable level for sounds was measured after surgery and the results of group A patients were compared with those obtained in group B (33 patients, who underwent standard surgery). One month after surgery, in group A patients, the cochleostapedial reflex was evoked in 21 patients (61.8 per cent) and two months later in 32 patients (94.1 per cent). One month after operation, in group A patients the mean uncomfortable level was 108.8 dB, while three months later it increased to 114.1 dB. In group B, the relevant values were 97.8 dB one month after surgery, and 98.0 dB three months later. Our presumption that stapedial muscle preservation is necessary has been proved by the fact that the patients with the preserved muscle had a higher noise discomfort threshold.

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Section: Discussionmentioning

confidence: 99%

Does it make sense to preserve the stapedial muscle during surgical treatment for otosclerosis?

Gros

Žargi²,

Vatovec³

2000

J. Laryngol. Otol.

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“…Thalmann et al 100 . found significantly increased collagenase levels in the tissue fluid of the media from human skin fibroblast cultures taken from patients with otosclerosis compared with normal subjects.…”

Section: Literature Studymentioning

confidence: 99%

The aetiology of otosclerosis: a review of the literature

2003

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During the last century, hundreds of studies have been performed to identify factors that are involved in the aetiology of otosclerosis. These studies include a variety of aetiological factors and, although many theories have been postulated, the process of the development of the disease remains unclear. A historical overview and analysis of the literature dealing with the aetiology of otosclerosis is presented. The role of collagen disorders, genetic linkage studies, associations with the HLA system and measles virus infection as causal factors is discussed. From an epidemiological point of view, the disease has an autosomal dominant mode of inheritance. Therefore, since the introduction of new genetic research techniques over the last decades, more studies have been performed to find evidence of a genetic factor that initiates the development of otosclerosis. In this review, we tried to categorize the most prominent studies in sections according to their subjects within the diversity of aetiological factors that have been studied.

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Evidence of Abnormal Stromelysin mRNA Expression in Suspected Carriers of Otosclerosis: A Possible Molecular Marker

McPhee

Gordon

Ruben³

et al. 1993

Archives of Otolaryngology - Head and Neck Surgery

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Otosclerosis: A local manifestation of a generalized connective tissue disorder?

Cited by 26 publications

References 29 publications

Does it make sense to preserve the stapedial muscle during surgical treatment for otosclerosis?

Does it make sense to preserve the stapedial muscle during surgical treatment for otosclerosis?

The aetiology of otosclerosis: a review of the literature

Evidence of Abnormal Stromelysin mRNA Expression in Suspected Carriers of Otosclerosis: A Possible Molecular Marker

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