Otoprotective Effects of Quercetin Against Oxidative Damage in the Rat's Cochlea Induced by Noise and Silver Nanoparticles

Goodarzi, Zahra; Khavanin, Ali; Karami, Esmaeil; Rashidy-Pour, Ali; Belji Kangarlou, Marzieh; Kiani, Mehrafarin; Razmjouei, Jaleh

doi:10.1016/j.neuroscience.2023.09.004

Cited by 1 publication

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“…Prior to in vivo administration, the Silver-NPs were dissolved in deionized water and sonicated for 15 min using a Branson Ultrasonics Corp device in order to achieve a more uniform distribution before injection into the systemic circulation. The protocol for analyzing the size, shape, phases, and crystal structure of the Silver-NPs was based on a study conducted by Goodarzi et al (Goodarzi et al, 2023; Zahra et al, 2022). All samples were prepared under sterile conditions.…”

Section: Methodsmentioning

confidence: 99%

Noise and silver nanoparticles induce hepatotoxicity via CYP450/NF-Kappa B 2 and p53 signaling pathways in a rat model

Belji Kangarlou,

Khavanin,

Nadri

et al. 2024

Toxicol Ind Health

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Co-exposure to noise and nanomaterials, such as silver nanoparticles (Silver-NPs), is a common occurrence in today’s industries. This study aimed to investigate the effects of exposure to noise and the administration of silver-NPs on the liver tissue of rats. Thirty-six adult male albino Wistar rats were randomly divided into six groups: a control group (administered saline intraperitoneally), two groups administered different doses of Silver-NPs (50 mg/kg and 100 mg/kg, 5 days a week for 28 days), two groups exposed to noise in addition to Silver-NPs (at the same doses as mentioned before), and a group exposed only to noise (104 dB, 6 hours a day, 5 days a week for 4 weeks). Blood samples were taken to assess hepatic-functional alterations, such as serum ALP, ALT, and AST levels. Additionally, biochemical parameters (MDA, GPX, and CAT) and the silver concentration in the liver were measured. Histopathological analysis, mRNA expression (P53 and NF-κB), protein expression (CYP450), and liver weight changes in rats were also documented. The study found that the administration of Silver-NPs and exposure to noise resulted in elevated levels of ALP, ALT, AST, and MDA ( p < .01). Conversely, GPX and CAT levels decreased in all groups compared with the control group ( p < .0001). There was a significant increase ( p < .05) in liver weight and silver concentration in the liver tissues of groups administered Silver-NPs (50 mg/kg) plus noise exposure, Silver-NPs (100 mg/kg), and Silver-NPs (100 mg/kg) plus noise exposure, respectively. The expression rate of P53, NF-κB, and cytochromes P450 (CYPs-450) was increased in the experimental groups ( p < .05). These findings were further confirmed by histopathological changes. In conclusion, this study demonstrated that exposure to noise and the administration of Silver-NPs exacerbated liver damage by increasing protein and gene expression, causing hepatic necrosis, altering biochemical parameters, and affecting liver weight.

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Section: Methodsmentioning

confidence: 99%