Otopathology of Vasculitis in Granulomatosis With Polyangitis

Santos, Felipe; Şalvız, Mehti; Domond, Haris; Nadol, Joseph B.

doi:10.1097/mao.0000000000000868

Cited by 27 publications

(24 citation statements)

References 11 publications

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“…Furthermore, our findings align with others who have demonstrated significant otalgia or facial paralysis in the presence of serous middle ear effusion as diagnostic indicators of GPA. 15 Other features demonstrated in our case series were pale granulation in the middle ear with apparent serous otitis media ( Figure 1A), otalgia in the presence of serous effusion, mixed hearing loss in patients with serous effusion, gingival lesions ( Figure 1B), nasal granulation, and subglottic stenosis.…”

Section: Discussionsupporting

confidence: 52%

A Case Series of Granulomatosis With Polyangiitis Primarily Diagnosed by Otological Manifestations

Sahyouni

Moshtaghi

Abouzari

et al. 2018

Ann Otol Rhinol Laryngol

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Objective: To describe a case series of previously undiagnosed granulomatosis with polyangiitis (GPA) patients who presented primarily with otological manifestations. Method: We report a series of patients visited at a neurotology clinic who were eventually diagnosed with GPA based on their otologic complaints and had no prior knowledge of having this condition. Results: In this series, 10 (91%) patients presented with hearing loss (HL), more than half of which were bilateral (60%). Upon audiometric examination, all but 1 patient had mixed, conductive, or sensorineural HL. All patients presented with eustachian tube dysfunction (ETD), otitis media with effusion (OME), or both. Nasal endoscopy showed intranasal pathology in 3 (27%) patients. Otologic symptoms were improved in all patients after treatment with an average of 4 inoffice follow-up appointments. Conclusion: GPA should be included in the differential diagnosis of adults with unexplained mixed hearing loss, new onset serous effusion, or acute otitis media in the absence of a previous history of ETD. Laboratory tests (ie, antineutrophil cytoplasmic autoantibody, erythrocyte sedimentation rate, and C-reactive protein) along with a urinalysis can aid in screening these patients. In cases in which the index of suspicion is high, repeated testing could reduce the risk of false negative findings.

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Section: Discussionsupporting

confidence: 52%

A Case Series of Granulomatosis With Polyangiitis Primarily Diagnosed by Otological Manifestations

Sahyouni

Moshtaghi

Abouzari

et al. 2018

Ann Otol Rhinol Laryngol

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“…84 Vasculitis related hearing loss may fluctuate with disease activity and may improve with steroids/ immunosuppression. 85 • Microbiology: Including testing for M tuberculosis and fungi.…”

Section: Imagingmentioning

confidence: 99%

Updates in antineutrophil cytoplasmic antibody (ANCA)‐associated vasculitis for the ENT surgeon

Coates

Pero

2020

Clinical Otolaryngology

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ENT involvement is common in ANCA-associated vasculitis (AAV), particularly in GPA and EGPA. Early recognition and treatment is important for good outcomes, yet evidence suggests that UK ENT surgeons may not consistently recognise the early features of AAV, despite a similar incidence to vestibular schwannoma. AAV is a rapidly advancing field, with significant developments in the understanding of its pathogenesis, classification and treatment over the past decade. Relevant vasculitis mimics are also discussed with a particular focus on the increasing prevalence of vasculitis mimics driven by an increase in recreational cocaine use, as well as the emergence and reclassification of several other vasculitis mimics in the head and neck. This article reviews key recent updates in the vasculitis literature, with a particular focus on those relevant to recognition and diagnosis of AAV for the ENT surgeon. Strengths and limitations of relevant diagnostic testing are discussed, and a method of evaluation of patients with features of AAV presenting to ENT services is outlined. | 317

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“…In the latter case, vertigo may be caused by acute dysfunction of the vestibular periphery, and it would be difficult to make a correct diagnosis of this condition at the early stage. Temporal bone histopathological studies in GPA patients revealed hemorrhages in the stroma of the crista of semicircular canals, changes in vessel caliber, and lymphocytic infiltration [ 163 ].…”

Section: Audiovestibular Pathology Associated With Systemic Autoimmentioning

confidence: 99%

Update on Vertigo in Autoimmune Disorders, from Diagnosis to Treatment

Girasoli

Cazzador

Padoan

et al. 2018

Journal of Immunology Research

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The prevalence of autoimmune diseases has been increasing over the last 20 years. The clinical presentation of this large and heterogeneous group of disorders depends on whether the involvement is organ-specific or non-organ-specific. Dizziness, vertigo, and disequilibrium are common symptoms reported by patients with vestibulocochlear involvement. The association of vertigo and autoimmune diseases has been largely documented, suggesting that autoimmune disorders could be overrepresented in patients with vertigo in comparison to the general population. The aim of this review is to present the recent literature findings in the field of autoimmune-mediated diseases with cochleovestibular involvement, focusing on the clinical presentation, diagnosis, and treatment of immune-mediated inner ear diseases including autoimmune inner ear disease (AIED), Meniere's disease, and bilateral vestibulopathy, as well as of systemic autoimmune diseases with audiovestibular disorders, namely, Behçet's disease, Cogan's syndrome, sarcoidosis, autoimmune thyroid disease, Vogt-Koyanagi-Harada syndrome, relapsing polychondritis, systemic lupus erythematosus, antiphospholipid syndrome, IgG4-related disease, and ANCA-associated vasculitides.

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Otopathology of Vasculitis in Granulomatosis With Polyangitis

Cited by 27 publications

References 11 publications

A Case Series of Granulomatosis With Polyangiitis Primarily Diagnosed by Otological Manifestations

A Case Series of Granulomatosis With Polyangiitis Primarily Diagnosed by Otological Manifestations

Updates in antineutrophil cytoplasmic antibody (ANCA)‐associated vasculitis for the ENT surgeon

Update on Vertigo in Autoimmune Disorders, from Diagnosis to Treatment

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