Otoneurosyphilis Masquerading as Neurofibromatosis Type II

Ahmad, Ijaz; Lee, W.C.

doi:10.1159/000027636

Cited by 10 publications

(8 citation statements)

References 14 publications

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“…Therefore, it is usually characterized by severe sensorineural hearing loss and vertigo. [95] Diagnosis is made through a dark-field microscopic examination of the ear discharge. The treatment is with anti-syphilitic drugs (Penicillin G, Aminoglycosides or Azithromycin).…”

Section: Specific Otitis Mediamentioning

confidence: 99%

Classification and management challenges of otitis media in a resource-poor country

Ibekwe

Nwaorgu

2011

Niger J Clin Pract

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The clinical features and sequelae of otitis media (OM) vary depending on the duration, severity and progression of the disease. As a result, opinions on the modes of classification and management protocols have differed over the years. The need to critically appraise these opinions according to the peculiarities of each region is imperative. This work was aimed at reviewing the world literature on the subject and also highlights the limitations in management in our region. A wide literature search was conducted using the following search engines: PubMed, AJOL and University of Toronto Library. Also incorporated were essential materials obtained from the authors' clinical practices. The search engines returned 22,903 related articles on OM. Further filtration yielded 88 articles on "classification and management" and these were obtained in full and thoroughly read. Extracted materials for review spanned between 1980 and 2008. OM is prevalent the world over with potentially severe complications if inadequately managed, especially in the developing countries. It is of note that in the developing countries, poverty, ignorance, dearth of specialists and limited access to medical care amongst others conspire to worsen the course and complications of OM.

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Section: Specific Otitis Mediamentioning

confidence: 99%

Classification and management challenges of otitis media in a resource-poor country

Ibekwe

Nwaorgu

2011

Niger J Clin Pract

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“…In adult patients endolymphatic hydrops was noted 17 . Late syphilis is characterized by formation of gummata that can also cause sensorineuronal hearing loss, tinnitus and vertigo 20 …”

Section: Discussionmentioning

confidence: 99%

“…17 Late syphilis is characterized by formation of gummata that can also cause sensorineuronal hearing loss, tinnitus and vertigo. 20 Early treatment is mandatory for excellent outcome. The treatment of choice is penicillin, either 1 MU clemizolpenicillin/day i.m.…”

Section: Discussionmentioning

confidence: 99%

Otosyphilis: report on six cases

Klemm

Wollina

2004

Acad Dermatol Venereol

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Syphilis is a multisystemic disease that may also affect the inner ear. The objective of this study was to investigate the frequency, clinical presentation and outcome of otosyphilis. A retrospective analysis of inpatients seen by a team of ENT specialists and dermatologists at a teaching hospital in Dresden, Germany, during 1986-2000. Six cases of otosyphilis had been diagnosed. None was related to risk factors such as HIV infection or drug abuse. We identified four female and two male patients, age range 25-58 years. Four patients suffered from syphilis stage II, one from syphilis stage and another from congenitial syphilis. ENT complaints included loss or impairment of hearing, tinnitus and nystagmus. All were treated with penicillin G. Adjuvant therapy included systemic corticosteroids oral pentoxifillin in two patients each. Improvement of ENT symptoms was achieved in all but one patient, who suffered from congenitial syphilis. This study confirms that otosyphilis is still a complication of syphilis in developed countries. The first line therapy is systemic penicillin G. There is a lack of controlled trials for adjuvant treatments such as corticosteroids and pentoxifillin. Clinical cooperation between dermatologists/venereologists and ENT specialists supports the best outcome.

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“…However, enhancement of a gumma does not have to be ring-like and can be associated with enhancement of adjacent meninges or cranial nerves [2,3], as with our case. Cerebral gumma have been misdiagnosed for other forms of tumor before [1,12], potentially leading to unnecessary biopsy or inappropriate treatment.…”

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confidence: 99%