Otolaryngologic presentations of amyotrophic lateral sclerosis

Chen, Anton; Garrett, C. Gaelyn

doi:10.1016/j.otohns.2004.09.092

Cited by 86 publications

(73 citation statements)

References 14 publications

(33 reference statements)

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“…Muscle weakness can be present with UMN and with LMN involvement. Regardless of the type of dysarthria, identifiable changes to speech are expected in over 90% of PALS as the disease progresses (Chen & Garrett, 2005). Speech intelligibility is reduced, and 80% or more of PALS may ultimately need an alternative communication method to function in daily activities (Beukelman, Fager, & Nordness, 2011).…”

mentioning

confidence: 99%

Lingual–Alveolar Contact Pressure During Speech in Amyotrophic Lateral Sclerosis: Preliminary Findings

Searl

Knollhoff

Barohn

2017

J Speech Lang Hear Res

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Purpose: This preliminary study on lingual-alveolar contact pressures (LACP) in people with amyotrophic lateral sclerosis (ALS) had several aims: (a) to evaluate whether the protocol induced fatigue, (b) to compare LACP during speech (LACP-Sp) and during maximum isometric pressing (LACP-Max) in people with ALS (PALS) versus healthy controls, (c) to compare the percentage of LACP-Max utilized during speech (%Max) for PALS versus controls, and (d) to evaluate relationships between LACP-Sp and LACP-Max with word intelligibility. Method: Thirteen PALS and 12 healthy volunteers produced /t, d, s, z, l, n/ sounds while LACP-Sp was recorded. LACP-Max was obtained before and after the speech protocol. Word intelligibility was obtained from auditory-perceptual judgments.Results: LACP-Max values measured before and after completion of the speech protocol did not differ. LACP-Sp and LACP-Max were statistically lower in the ALS bulbar group compared with controls and PALS with only spinal symptoms. There was no statistical difference between groups for %Max. LACP-Sp and LACP-Max were correlated with word intelligibility. Conclusions: It was feasible to obtain LACP-Sp measures without inducing fatigue. Reductions in LACP-Sp and LACP-Max for bulbar speakers might reflect tongue weakness. Although confirmation of results is needed, the data indicate that individuals with high word intelligibility maintained LACP-Sp at or above 2 kPa and LACP-Max at or above 50 kPa.

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mentioning

confidence: 99%

Lingual–Alveolar Contact Pressure During Speech in Amyotrophic Lateral Sclerosis: Preliminary Findings

Searl

Knollhoff

Barohn

2017

J Speech Lang Hear Res

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“…17 However, "quivering" of the arytenoids and/or TVFs has not been previously reported. In this study, quivering of the arytenoids and/or TVFs was observed in 8/12 MND subjects.…”

Section: Other Laryngeal Observationsmentioning

confidence: 96%

“…16 Variability has also been noted in patterns of abnormal TVF movements, with the following patterns reported: incomplete adduction, bowing, hyperfunction, and reduced abduction. 17 Laryngospasm and glottic narrowing have also been reported in bulbar ALS.…”

Section: Dystussia In Motor Neuron Disease (Mnd)mentioning

confidence: 99%

“…9 Although cough dysfunction in those with bulbar involvement is not well understood, it is recognized that people with bulbar ALS frequently experience laryngeal dysfunction. 16,17 Examining TVF kinematics and adequacy of airway patency during cough has important clinician implications. For instance, cough dysfunction, especially when combined with bulbar impairments, leads to higher risk for respiratory failure.…”

Section: 9mentioning

confidence: 99%

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Associations Between Laryngeal and Cough Dysfunction in Motor Neuron Disease with Bulbar Involvement

et al. 2014

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“…Approximately 85% of individuals with ALS experience dysphagia, or swallowing impairment, leading to malnutrition, dehydration, aspiration, pneumonia, reduced psychosocial health, and morbidity 2, 3. Progressive rigidity and weakness of the diaphragm, internal intercostals and abdominal muscles also contribute to impairments in the ability to generate adequate subglottic air pressure to produce a protective and effective cough 4, 5.…”

Section: Introductionmentioning

confidence: 99%

Respiratory training in an individual with amyotrophic lateral sclerosis

Tabor

Rosado

Robison

et al. 2016

Ann Clin Transl Neurol

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We examined the impact of expiratory muscle strength training on maximum expiratory pressure, cough spirometry, and disease progression in a 71‐year‐old male with amyotrophic lateral sclerosis. Maximum expiratory pressure declined 9% over an 8‐week sham training period, but subsequently improved by 102% following 8 weeks of expiratory muscle strength training. Improvements in cough spirometry and mitigated disease progression were also observed post expiratory muscle strength training. Improvements in maximum expiratory pressures were maintained 6 months following expiratory muscle strength training and were 79% higher than baseline data obtained 301 days prior. In this spinal‐onset amyotrophic lateral sclerosis patient, respiratory training improved subglottic air pressure generation and sequential cough generation.

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Otolaryngologic presentations of amyotrophic lateral sclerosis

Abstract: C.

Cited by 86 publications

References 14 publications

Lingual–Alveolar Contact Pressure During Speech in Amyotrophic Lateral Sclerosis: Preliminary Findings

Lingual–Alveolar Contact Pressure During Speech in Amyotrophic Lateral Sclerosis: Preliminary Findings

Associations Between Laryngeal and Cough Dysfunction in Motor Neuron Disease with Bulbar Involvement

Respiratory training in an individual with amyotrophic lateral sclerosis

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