Otoacoustic Emissions for Monitoring Aminoglycoside-Induced Ototoxicity in Children With Cystic Fibrosis

Stavroulaki, Pelagia; Vossinakis, I. C.; Dinopoulou, Dimitra; Doudounakis, Spiros; Adamopoulos, G.; Apostolopoulos, Nikolaos

doi:10.1001/archotol.128.2.150

Cited by 59 publications

(58 citation statements)

References 22 publications

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“…Under such assumptions, it is recommended to include otoacoustic emissions in the assessment protocol when the patient is unable to respond to the behavioral tests, having seen that many papers confirm its clinical application on the early detection of ototoxicity 8,9,14,21,22,[39][40][41][42][43][44][45][46][47][48]50 . It is worth stressing that, as aforementioned, since the frequency range assessed in TEEOE is carried out between 1 and 4kHz, DPEOAE should not be excluded, because TEEOE may be present even when there are alterations in the outer hair cells in the most basal portion of the spiral organ (base membrane vibration for those sounds in frequencies above 4kHz) 48 .…”

Section: Discussionmentioning

confidence: 99%

“…Because of this very property, this procedure has been used in hearing monitoring in order to check cochlear alterations caused by ototoxic drugs, by means of reducing the amplitude of emissions before alterations happen to the tonal thresholds 8,9,21,22,[39][40][41][42][43][44][45][46] . Moreover, this is an objective analysis (and not behavioral), that may be carried out even when the child is asleep.…”

Section: Literature Reviewmentioning

confidence: 99%

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Monitoramento auditivo na ototoxidade

Jacob-Corteletti

Aguiar

Tomiasi

et al. 2006

Rev. Bras. Otorrinolaringol.

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Algumas drogas, denominadas ototóxicas, têm a capacidade de lesar os sistemas auditivo e vestibular. O avanço tecnológico tem disponibilizado inúmeros recursos para realizar o monitoramento da audição, porém, apesar da disponibilização de protocolos de avaliação internacionais, existem controvérsias quanto à escolha do procedimento de maior sensibilidade e especificidade para este fim. OBJETIVO: Analisar os procedimentos audiológicos utilizados no monitoramento auditivo dos indivíduos expostos à medicação ototóxica. METODOLOGIA: Realizou-se busca eletrônica nas bases de dados MEDLINE e LILACS, a partir da combinação entre os descritores que caracterizaram as temáticas monitoramento auditivo, ototoxicidade e câncer. A literatura apontou dois principais procedimentos efetivos no monitoramento: a audiometria de altas freqüências e as emissões otoacústicas. Ambos permitem que a alteração no sistema auditivo seja identificada antes que haja um comprometimento dos limiares tonais na faixa de freqüências convencional, e conseqüentemente na habilidade de compreensão da fala. CONCLUSÃO: O protocolo de monitoramento auditivo foi sugerido considerando a capacidade do paciente em responder aos testes comportamentais e a etapa do monitoramento (primeira avaliação ou subseqüentes). No caso de portadores de câncer, o monitoramento auditivo deve ser disponibilizado no local de tratamento do indivíduo.

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Section: Discussionmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

Monitoramento auditivo na ototoxidade

Jacob-Corteletti

Aguiar

Tomiasi

et al. 2006

Rev. Bras. Otorrinolaringol.

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“…Furthermore, DPOAEs are believed to be sensitive to subtle cochlear damage before it becomes apparent using pure-tone threshold testing (Mulheran & Degg 1997;Katbamna et al 1999;Stavroulaki et al 2002;Lapsley Miller & Marshall 2007;Helleman & Dreschler 2012). Finally, DPOAEs have the distinct advantages of being fast to obtain, nonbehavioral (capable of assessing cochlear function in inattentive patients, such as newborns or critically ill patients), and obtainable by nonspecialist staff with specific training in making emission measurements.…”

Section: Introductionmentioning

confidence: 99%

Meta-Analysis of Distortion Product Otoacoustic Emission Retest Variability for Serial Monitoring of Cochlear Function in Adults

et al. 2015

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Objective-Distortion product otoacoustic emissions (DPOAEs) have long been heralded as a means to objectively monitor cochlear function and increasingly are becoming a key component in hearing surveillance programs for individuals at risk for ototoxic-and occupational noise-related hearing loss. Yet clinicians are unsure how to define clinically meaningful shifts in DPOAE level. In this study, a meta-analysis approach is used to synthesize the DPOAE level test-retest literature to construct a set of DPOAE level shift reference limits that can be used clinically to define a statistically significant emission change.Design-The authors reviewed all published articles identified through a Medline search using the terms "Otoacoustic Emission Variability," "Otoacoustic Emission Reliability," "Otoacoustic Emission Repeatability," and "Otoacoustic Emission Test Retest" restricted to DPOAEs, adults, and English language. Articles with DPOAE level data elicited by moderate stimulus levels for f 2 frequencies of 1000, 2000, 4000, or 6000 Hz were selected because these stimulus parameters were relatively well represented in the literature. The authors only included articles that reported the standard error of the measurement (SEM) or from which the SEM could be calculated. Metaanalysis was used to estimate the population mean SEM over the included studies. Models were fit separately for each f 2 primary and included days since baseline and study-specific random effects.Results-Ten DPOAE test-retest studies met inclusion criteria for this meta-analysis. The SEM values varied widely across published studies (0.57 to 3.9 dB) and were provided for relatively short time intervals (less than 15 days on average). Time, or days since baseline, was statistically significant at higher f 2 frequencies (4000 and 6000 Hz). From the model results, 90% reference limits specific to the f 2 and elapsed time between baseline and follow-up measurements were established. Reference limits provided correspond to negative (emission decrement) and positive (emission enhancement) shifts indicative of the amount of measurement variability that, using this U.S. Department of Veterans AffairsPublic Access Author manuscript Ear Hear. Author manuscript; available in PMC 2015 November 04. VA Author ManuscriptVA Author Manuscript VA Author Manuscript approach, must be tolerated as "normal" fluctuations over time. Changes larger than the reference limits are considered significant and warrant follow-up testing.Conclusions-The meta-analysis presented provides reference limits that are appropriate for a set of specific f 2 frequencies and time intervals. The meta-analysis concerns the SEM statistic directly, so that any preferred reference limit can be computed from the results and should be predicated upon the screening application. The presumed advantage of this meta-analytic approach is increased precision relative to limits suggested by any of the individual studies included in the analysis.

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“…During ototoxicity monitoring, the patient should have OAE testing completed at baseline and before each administration of the ototoxic medication. A change of 2.4 dB was reported as a significant decrease [9], OAEs are a good clinical choice in monitoring for ototoxicity because they are quick. Because they can show a change in cochlear function before it appears on the audiogram, further testing can be avoided unless OAE testing suggests a need.…”

Section: Discussionmentioning

confidence: 99%

Role of Transient Evoked Otoacoustic Emission Beyond Screening of Hearing Impairment: A Study of 400 Cases

Meena

Babu

et al. 2012

Indian J Otolaryngol Head Neck Surg

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The primary purpose of this study was to investigate the potential role of transient-evoked Otoacoustic emissions (TEOAEs) beyond screening for hearing impairment in different middle/inner ear disorders in 3-65 years age group. Because TEOAEs are present in ears with normal cochlear and middle ear function and typically are absent or reduced in ears with cochlear and/or middle ear disorders of even mild degree. This was a prospective study of four hundred cases. Out of these 364 cases were having problems related to otology and 36 were healthy volunteers who attended the department of otorhinolaryngology of our institute. All the cases were kept in different eight groups and then subjected to Otoacoustic emission testing with the 'GSI AUDIO screener' equipment installed in our ENT department. The data obtained in all groups were analyzed and conclusion was made. TEOAEs is a reliable, simple and cost effective screening technique for hearing disorders with sensitivity varying from 72 to 96.42 % among the study groups and 88 % in composite group comprising all study groups.

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Otoacoustic Emissions for Monitoring Aminoglycoside-Induced Ototoxicity in Children With Cystic Fibrosis

Abstract: Otoacoustic emissions measurement (especially of DP OAEs) proved more sensitive than PTA in revealing minor cochlear dysfunction after gentamicin exposure. They should be used for monitoring patients receiving ototoxic factors such as aminoglycosides.

Cited by 59 publications

References 22 publications

Monitoramento auditivo na ototoxidade

Monitoramento auditivo na ototoxidade

Meta-Analysis of Distortion Product Otoacoustic Emission Retest Variability for Serial Monitoring of Cochlear Function in Adults

Role of Transient Evoked Otoacoustic Emission Beyond Screening of Hearing Impairment: A Study of 400 Cases

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