Otitis media in coronavirus disease 2019: a case series

Raad, Nasim; Ghorbani, Jahangir; Mikaniki, Narges; Haseli, Sara; Karimi-Galougahi, Mahboobeh

doi:10.1017/s0022215120002741

Cited by 37 publications

(63 citation statements)

References 6 publications

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“…Seventeen case reports and one case series reported hearing loss as a potential COVID-19 related symptom; of these, nine reported sensorineural hearing loss (23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34).…”

Section: Discussionmentioning

confidence: 99%

Acute Vertigo After COVID-19 Vaccination: Case Series and Literature Review

et al. 2022

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Objective: The aim of this study was to present some cases of acute vertigo potentially related to the coronavirus disease 2019 (COVID-19) vaccine and review the available literature about cochleovestibular dysfunction after the COVID-19 vaccination.Methods: In the period from May to July 2021, we evaluated 33 patients (mean age 54.3 ± 14.1) with “acute vertigo” post COVID-19 vaccination. A detailed medical history was taken on comorbidities, types of vaccines received, and symptoms associated. All patients underwent otoneurological evaluation, such as head impulse test, nystagmus evaluation, test of skew (HINTS) examination. Head shaking test-induced nystagmus, hyperventilation-induced nystagmus, and parossistic positional nystagmus were studied to search for vestibular impairment.Results: Symptoms included 16 patients (48.5%) with objective vertigo, 14 patients (42.4%) with subjective vertigo, and 3 patients (9.1%) with dizziness. Of the associated ear, nose, and throat (ENT) symptoms, the most expressed was tinnitus (18.2%). Bedside examination showed absent nystagmus in 7 patients (21.2%), 9 patients (27.3%) had horizontal or rotatory nystagmus, 17 patients (51.5%) had a vertical or oblique nystagmus, negative HST, or “central HINTS.”Discussion and Conclusions: The 9 patients had an evoked nystagmus pathognomonic for benign paroxysmal positional vertigo; in the remaining 17 cases, peripheral vestibular dysfunction could be excluded and central disorder may be suggested. Due to the prevalence of nystagmus of non-peripheral origin, a central nervous system involvement could not be excluded. However, due to the small sample size, a definite cause–effect relationship between vaccination and vertigo cannot be inferred. In light of expected third dose, large-scale and well-designed studies are needed to better define possible adverse reactions of the COVID-19 vaccine.

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Section: Discussionmentioning

confidence: 99%

Acute Vertigo After COVID-19 Vaccination: Case Series and Literature Review

et al. 2022

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“…In the literature, it has been stated that otitis findings may be the first sign for Covid-19 infection in some cases, and case series are reported (16). In our case, the hearing loss that developed while our patient was receiving Covid-19 pneumonia treatment was thought to be due to, serous otitis, a complication of Covid-19.…”

Section: Discussionmentioning

confidence: 52%

A rare case: Covid-19 infection diagnosed by transthoracic fine needle aspiration biopsy

Özdemirel¹,

Akkurt²,

Ertan³

et al. 2021

J Exp Clin Med

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Covid 19 is an acute respiratory disease caused by a novel type of Coronavirus (SARS-CoV-2) that was first detected in Wuhan, Hubei Province of China. Its most common symptoms are fever, cough, and weakness; and in the early stages, there may not be findings on chest computed tomography. In pulmonary involvement, peripheral ground-glass areas, a cobblestone appearance, consolidated areas, and interlobular septal thickening, which are usually prominent in the lower lobes may be seen in thorax computed tomography. Consolidation, solid nodules, halo sign, inverted halo sign, vascular enlargement, subpleural line, air bronchograms, and bronchiectasis are other less common findings. In our case, we aimed to present our 69 years old female patient with bilateral nodular densities on thoracic CT and transthoracic fine-needle aspiration biopsy result was reported as lesions compatible with interstitial fibrosis due to Covid-19 inflammation.

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“…Otitis media can be either a clinical manifestation or a complication of COVID-19. Clinical otologic disorders, especially hearing loss, may signal the presence of COVID-19 disease [ 8 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

“…Fidan [ 6 ] reported the first case of otitis media in a COVID-19 patient in April 2020, and in October 2020, Frazier et al [ 7 ] reported for the first time the isolation of SARS-CoV-2 from mastoid and middle ear specimens in deceased COVID-19 patients. In January 2021, Raad et al [ 8 ] published a series of eight otitis media cases in COVID-19 patients, arguing that otitis media can be considered an associated manifestation of COVID-19. Thus, there is increasing evidence suggesting that otologic disorders, particularly hearing loss, may belong to the clinical spectrum of COVID-19 and, in some cases, may signal the presence of the disease [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Evidence of SARS-CoV-2 Virus in the Middle Ear of Deceased COVID-19 Patients

Jeican

Aluaș

Lazăr³

et al. 2021

Diagnostics

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The presence of SARS-CoV-2 in the middle ear reveals the etiopathogenesis of otitis media in COVID-19, as well as an epidemiological risk during otologic examination and surgical procedures in COVID-19 patients. The study included 8 deceased patients with COVID-19. Tissue samples from the middle ear were subjected to virology, histopathology, scanning (SEM) and transmission (TEM) electron microscopy investigation. Ethmoidal mucosa samples were processed for virology analyses. qPCR resulted positive for 75% of nasal mucosa samples and 50% of middle ear samples. Ct values showed lower viral loads in middle ear samples. A proportion of 66.6% patients with positive results in the nasal mucosa showed positive results in the middle ear, and the subtype analysis of the complete genome sequences indicated B.1.1.7 lineage for all samples. In histopathological and SEM samples, no pathological aspects were identified. TEM revealed on the background of death critical alteration of cellular morphology, suggestive structures resembling SARS-CoV-2, goblet cells and immune cells. SARS-CoV-2 can be present in the middle ear of COVID-19 patients even if there is not clinical evidence of acute otitis media. Otolaryngologists could be particularly exposed to COVID-19 infection.

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Otitis media in coronavirus disease 2019: a case series

Cited by 37 publications

References 6 publications

Acute Vertigo After COVID-19 Vaccination: Case Series and Literature Review

Acute Vertigo After COVID-19 Vaccination: Case Series and Literature Review

A rare case: Covid-19 infection diagnosed by transthoracic fine needle aspiration biopsy

Evidence of SARS-CoV-2 Virus in the Middle Ear of Deceased COVID-19 Patients

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