Otitis Media and Hearing Loss in Patients With Nonsyndromic Craniosynostosis: A Multicenter Study

Grewal, Jeewanjot S.; Cohn, Jason E.; Burdett, Jacob; Tampio, Alex J F; Licata, Jordan; Davis, Wellington J.; Tatum, Sherard A.; Nicholas, Brian D.

doi:10.1177/10556656211017795

Cited by 5 publications

(4 citation statements)

References 22 publications

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“…Though these outcomes are more commonly associated with syndromic cases [17, 19, 42, 43], some studies have explored the presence of chronic otitis media and hearing loss in the NSC population. Grewal et al [18] reported that 36% of their 113-patient NSC cohort had experienced at least one episode of otitis media, falling within the upper limit of normal when compared to historical rates among normocephalic children, and only 9% of NSC patients were found to have hearing loss; however, this study did not report a breakdown of prevalence rates by sex. Similarly, Prager et al [20] found 26% of 57 NSC patients presented with hearing loss, a frequency that was not significantly higher than the normal population of a similar age, and only a quarter of NSC patients with hearing loss were female.…”

Section: Discussionmentioning

confidence: 69%

“…With these structural impacts on nearby anatomical features and the subsequent risk of increased ICP, craniosynostosis patients may present with consequent ophthalmological diagnoses, such as strabismus, papilledema, or exophthalmos [6][7][8][9][10]. Associations have also been reported with developmental delays, obstructive sleep apnea, chronic otitis media, hearing loss, chronic headaches, and seizure disorders [11][12][13][14][15][16][17][18][19][20][21]. Despite these correlations, substantial evolution in NSC management has led to improved outcomes in these patients, and the genetic pathophysiology of NSC craniosynostosis is becoming increasingly better understood with the development of next-generation sequencing technologies [22,23].…”

Section: Introductionmentioning

confidence: 99%

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Sex Differences in Comorbidities of Pediatric Craniosynostosis at Presentation

Presto¹,

Collins²,

Garza³

et al. 2022

Pediatr Neurosurg

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Introduction: Craniosynostosis is a common pediatric presentation in which the premature fusion of one or more cranial sutures results in a misshapen skull. This birth defect is often associated with comorbidities due to structural impacts on nearby anatomical features. While there is some evidence for a male-predominance among craniosynostosis patients, little has been investigated regarding sex differences in comorbidities of this condition. This study seeks to explore potential sexual dimorphisms in craniosynostosis patients at the time of presentation. Methods: We conducted a retrospective, cross-sectional review of male and female non-syndromic craniosynostosis (NSC) patients between the ages of 1 month and 9 years that were evaluated at a 500-bed academic hospital or a 977-bed private hospital in Lubbock, Texas, United States. Common comorbidities including ophthalmologic diagnoses, developmental delays, obstructive sleep apnea, chronic otitis media, hearing loss, chronic headaches, and seizure disorders were evaluated. The NSC cohort was compared to a similarly-aged trauma group that represented the normal population. Results: 175 NSC patients fit the inclusion criteria, of which 109 (62%) were male. A diagnosis of craniosynostosis was significantly associated with ophthalmological diagnoses (p < 0.0001), chronic otitis media (p < 0.0001), developmental delays (p < 0.0001), and hearing loss (p = 0.0047). Male NSC patients were less likely to present with ophthalmological diagnoses (p = 0.0010) or hearing loss (p = 0.0052) than females. Conclusions: Our findings expand on current literature evaluating possible comorbidities of NSC, particularly supporting the association with ophthalmological diagnoses, chronic otitis media, developmental delays, and hearing loss. We also report sex differences in ophthalmological diagnoses and hearing loss for NSC patients. These findings can serve to educate physicians of symptoms requiring prompt recognition and management in these patients.

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Section: Discussionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Sex Differences in Comorbidities of Pediatric Craniosynostosis at Presentation

Presto¹,

Collins²,

Garza³

et al. 2022

Pediatr Neurosurg

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“…Between the ages of 3 and 5, the rapid growth of the nasopharynx's soft tissue can constrict the nasopharyngeal airway. However, as the nasopharynx opens, the soft tissues are largely spared (3). Factors like allergies and environmental toxins can induce adenoid hypertrophy, causing the adenoid tissue to enlarge when exposed to allergens and irritants.…”

Section: Introductionmentioning

confidence: 99%

Severity and Types of Hearing Loss in Patients with Hypertrophic Adenoids

Akhtar,

Khan,

Badar

et al. 2023

JHRR

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Background: Hearing loss in children can significantly impact language development and social interaction. Hypertrophic adenoids are a common pediatric condition that can contribute to hearing impairments. Understanding the prevalence and severity of hearing loss in this demographic is crucial for effective management and intervention strategies. Objective: The study aimed to determine the prevalence and severity of hearing loss among children with hypertrophic adenoids, assessing the demographic characteristics and the types of hearing loss observed in this population. Methods: This observational cross-sectional survey was conducted over nine months at the Children's Hospital and Institute of Child Health, University of Lahore Teaching Hospital. The study included a sample size of 339 children aged 5-13 years, calculated based on a prevalence rate of 67.3% for mild hearing loss. Children with comorbidities like Down syndrome, Autism, ADHD, and other disabilities were excluded. Hearing assessments were conducted using an otoscope, a tympanometer, and a diagnostic audiometer (MAICO MA41 model). Data were analyzed using SPSS Version 25.0, focusing on the frequency and percentage of various types of hearing loss. Results: The study included 183 males (54%) and 156 females (46%), with a higher representation from rural areas (60%, n=203). Tympanometric analysis revealed 51.9% (n=176) with Type A tympanograms, 43.1% (n=146) with Type B, and 5% (n=17) with Type C. Audiometric results showed that 53.1% (n=180) of participants had normal hearing levels, while 27.1% (n=92) experienced mild hearing loss, 16.2% (n=55) had moderate hearing loss, 3.5% (n=12) had moderately severe hearing loss, 1.5% (n=5) had sensorineural hearing loss, and 2.1% (n=7) had mixed hearing loss. Conclusion: The study demonstrates a significant occurrence of mild to moderate conductive hearing loss in children with hypertrophic adenoids, particularly in rural settings. These findings highlight the need for regular auditory screening and early intervention strategies in this demographic to prevent long-term speech and language complications.

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“…Additionally, this study examined the impact of probiotics on the incidence of otitis media in children with cleft lip and/or palate (CL/P), a birth defect with highest susceptibility to recurrent otitis media [23,24]. Probiotics have been thoroughly examined for the prevention of childhood otitis media [16,17]; however, the potential bene ts in children with CL/P remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Impact of Habitual Yogurt Intake in Mother–Child Dyads on Incidence of Childhood Otitis Media: The Japan Environment and Children’s Study (JECS)

Tsuchiya

Momma

et al. 2023

Probiotics & Antimicro. Prot.

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Otitis media, one of the most common childhood diseases, is characterized by in ammation or infection of the middle ear. Due to their ease of access, daily probiotics are recommended for the prevention of early childhood otitis media. This study aimed to assess the impact of probiotics on the incidence of otitis media using a dataset (n = 95,380) from the Japan Environment and Children's Study, a nationwide birth cohort study. After multiple imputations, the association between the incidence of otitis media in early childhood and the daily frequency of yogurt intake in children and mothers was examined using a generalized linear model with adjusting for several confounders. Repeated incidence of otitis media during the two years after birth was found in 14,874 participants (15.6%). Based on participants with the lowest frequency of yogurt intake ("almost never") as the reference group, risk ratios (95% con dence interval) for otitis media incidence decreased with higher frequencies of yogurt intake in children at one year of age, but also independently in mothers during pregnancy. Furthermore, although not statistically signi cant, a similar association was observed in the subgroup of those with cleft lip and/or palate (CL/P), a high risk group for severe otitis media. Thus, increased regular yogurt intake in both children and mothers was associated with a decrease in early childhood otitis media.c Additionally adjusted for the other daily frequency of yogurt intake in children or in mothers with Model 2.

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Otitis Media and Hearing Loss in Patients With Nonsyndromic Craniosynostosis: A Multicenter Study

Cited by 5 publications

References 22 publications

Sex Differences in Comorbidities of Pediatric Craniosynostosis at Presentation

Sex Differences in Comorbidities of Pediatric Craniosynostosis at Presentation

Severity and Types of Hearing Loss in Patients with Hypertrophic Adenoids

Impact of Habitual Yogurt Intake in Mother–Child Dyads on Incidence of Childhood Otitis Media: The Japan Environment and Children’s Study (JECS)

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