Otitis externa und media bei Hund und Katze

Линек, Моника

doi:10.1055/s-0038-1623612

Cited by 10 publications

(22 citation statements)

References 77 publications

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“…Thus, with the right management, a response to treatment can be anticipated in most cases, especially in first‐time infections . Considering their ability to readily acquire resistance, choosing a topical therapy for Pseudomonas otitis should preferably be based on culture and susceptibility testing, to avoid a selection of resistant organisms and prevent treatment failure . However, in vitro susceptibilities are usually based on the serum concentration of the chosen drug and therefore may not reflect its efficacy when used topically at higher concentrations .…”

Section: Introductionmentioning

confidence: 99%

Determination of minimum inhibitory concentrations for silver sulfadiazine and other topical antimicrobial agents against strains of Pseudomonas aeruginosa isolated from canine otitis externa

Silva-Tarouca

Wolf

Mueller

2019

Veterinary Dermatology

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Background -Otitis externa is a common presenting complaint in practice. Ear infections by Pseudomonas aeruginosa are particularly problematic due to the organism's high level of resistance and ability to damage the tympanum. Treatment should be based on susceptibility testing although minimum inhibitory concentrations (MICs) are not available for all treatment options. Silver sulfadiazine has been used in cases of recurrent P. aeruginosa otitis, although a MIC for silver sulfadiazine as a single agent has not been established.Objectives -To describe susceptibility patterns of P. aeruginosa isolated from canine otitis externa and determine the MIC for silver sulfadiazine and other topical antimicrobials.Animals -Thirty-six P. aeruginosa isolates were collected from client-owned dogs, suffering from otitis externa.Methods and materials -Susceptibility patterns were established using disc diffusion susceptibility testing against 17 antimicrobial agents. For determination of the MIC, selected strains were tested against increasing concentrations of marbofloxacin, enrofloxacin, gentamicin, polymyxin B and silver sulfadiazine using broth microdilution.Results -For nine of 17 antimicrobial agents, complete resistance was seen in all isolates tested via disk diffusion susceptibility testing. Approximately 94% and 96% of isolates were susceptible to gentamicin and imipenem, respectively. These findings were consistent with broth dilution, where all strains were susceptible to gentamicin. Resistance was higher against polymyxin B and the fluoroquinolones. Silver sulfadiazine was effective in vitro with a MIC ranging from 1 to 64 lg/mL. Conclusions and clinical significance -As the MIC of silver sulfadiazine was lower than the concentration in a 1% preparation, such a product potentially represents a treatment option for dogs with P. aeruginosa otitis.

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Section: Introductionmentioning

confidence: 99%

Determination of minimum inhibitory concentrations for silver sulfadiazine and other topical antimicrobial agents against strains of Pseudomonas aeruginosa isolated from canine otitis externa

Silva-Tarouca

Wolf

Mueller

2019

Veterinary Dermatology

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“…It is a syndrome with a multifactorial aetiology. The factors are classified as predisposing (increase the risk of otitis), primary (directly induce otitis), secondary (contribute to otitis only in an abnormal ear or in conjunction with predisposing factors), and perpetuating (result from inflammation and pathology in the ear, prevent resolution of otitis) [3-6]. …”

Section: Introductionmentioning

confidence: 99%

“…Multipurpose products (otic preparations) exhibiting antibacterial, antifungal or anti-inflammatory properties are frequently indicated, particularly initially, because of the mix of microorganisms, inflammation and sometimes, parasites that are present at the time of diagnosis [1,3]. According to the package leaflets of such otic preparations, the topical treatment should be performed after mechanical (not supported by many specialists) or chemical removal of cerumen from the external ear canal [15,16].…”

Section: Introductionmentioning

confidence: 99%

Ceruminal diffusion activities and ceruminolytic characteristics of otic preparations – an in-vitro study

Stahl

Mielke

Pankow³

et al. 2013

BMC Vet Res

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BackgroundAn in-vitro setup was established in order to determine a) the diffusion activities of eight otic preparations (Aurizon®, Eas Otic®, Epi Otic®, Otifree®, Otomax®, Panolog®, Posatex®, Surolan®) through synthetic cerumen, and b) the ceruminolytic capacity and impregnation effects of these products. The main lipid classes of canine cerumen produced with moderate, non-purulent otitis externa were determined by thin layer chromatography and were subsequently used to produce a standardised synthetic cerumen (SCC). SCC was filled into capillary tubes, all of which were loaded with six commercially available multipurpose otic medications and two ear cleaners, each mixed with two markers in two experimental setups. These two marker compounds (Oil red O and marbofloxacin) were chosen, since they exhibit different physicochemical drug characteristics by which it is possible to determine and verify the diffusion activity of different types of liquids (i.e. the otic preparations). A synthetic cerumen described in the literature (JSL) was also used for comparison as its lipid composition was different to SCC. The diffusion activities of the otic preparations through both types of synthetic cerumen were studied over 24 hours. A second in-vitro experiment determined both the ceruminolytic activity and impregnation effect of the otic preparations by comparing the weight loss or weight gain after repeated incubation of JSL.ResultsCanine cerumen is mainly composed of triglycerides, sterol esters, fatty acid esters and squalene. The diffusion experiments showed a high diffusion efficacy along with a high impregnation effect for one test product. All the other products exhibited a lower diffusion activity with a mild to moderate impregnation effect. A mild ceruminolytic activity was observed for the two ear cleaners but not for any of the otic medications.ConclusionsThe present study demonstrates that there are significant differences in the diffusion characteristics and ceruminolytic properties of the eight tested otic preparations.

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“…Bakteriologische Untersuchungen und Antibiogramme liefern die Diagnose der Bakterienspezies mit deren Resistenzsituation (1,18). Die semiquantitative Beurteilung einer zytologischen Probe ermöglicht bei unterschiedlicher Anzahl der verschiedenen Bakterientypen die Auswahl der geeigneten antimikrobiellen Therapie für den zahlenmäßig dominierenden oder der Morphologie nach vermutlich pathogenen Keimtyp (15,21). Auch die Therapiekontrolle erfolgt über die Zytologie mit Dokumentation der Zahl an Zellen und Mikroorganismen (1,20).…”

Section: Introductionunclassified

“…In der Regel wird ein Abstrich aus dem Übergang vom vertikalen zum horizontalen Gehörgang genommen (1). Routinemäßig wird eine Schnellfärbung vom Romanowsky-Typ wie Diff-Quik® oder Hemacolor® (4,15), teils auch die Gramfärbung (18,21) angewendet. Eine Arbeitserleichterung kann ein einphasiges Färbesystem wie das Otitis-Schnellfärbeset sein.…”

Section: Introductionunclassified

Vergleich von vier zytologischen Färbeverfahren für Ohrabstriche beim Hund

Bouassiba

Osthold²,

Mueller³

2013

Tierarztl Prax Ausg K

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ZusammenfassungDie zytologische Untersuchung nimmt in der Diagnostik wie auch Klassifizierung der kaninen Otitis externa eine zentrale Stellung ein. Die Färbung der Abstriche soll Mikroorganismen als perpetuierende Faktoren der Otitis externa erkennen lassen. Ziel der Studie war, vier verschiedene Färbeverfahren (Diff-Quik®, Diff-Quik® mit Acetontauchverfahren vorab, Gram-color-Färbeset® sowie ein Otitis-Schnellfärbeset) für Ohrabstriche von Hunden mit Otitis externa zu vergleichen und die Übereinstimmung von zytologischer und mikrobiologischer Untersuchung zu eruieren.Im Rahmen einer Studie an Hunden mit Otitis externa wurden unmittelbar nacheinander von insgesamt 224 Ohren je ein steriler Abstrich für eine mikrobiologische Untersuchung und vier Ohrtupfer für die zytologische Untersuchung aus dem horizontalen Teil des äußeren Gehörgangs entnommen. Die Beurteilung der Abstriche erfolgte semiquantitativ.Diff-Quik® mit und ohne Aceton sowie das Gram-color-Färbeset® wiesen hohe Übereinstimmungen bei der Detektion von Mikroorganismen auf (Kokken p = 0,2366; Stäbchen p = 0,4832; Hefen p = 0,1574), während das Otitis-Schnellfärbeset signifikant weniger Mikroorganismen aufzeigte (p < 0,001 für alle Vergleiche). Im Fall der drei erstgenannten Färbungen deckten sich die Ergebnisse bei über 70% mit dem mikrobiologischen Befund, das Resultat des Otitis-Schnellfärbesets lag etwas darunter. Am schnellsten und einfachsten in der Durchführung erwies sich die Färbung mit Diff-Quik®.Diff-Quik® mit und ohne Aceton sowie das Gram-color-Färbeset® sind bei der Diagnostik der Otitis externa infectiosa nahezu gleichwertig. Weniger geeignet ist das Otitis-Schnellfärbeset.Aufgrund der Ergebnisse dieser Studie kann für die routinemäßige zytologische Untersuchung von Ohrabstrichen Diff-Quik® empfohlen werden. Eine mikrobiologische Untersuchung kann ergänzend indiziert sein und wird in Verbindung mit dem zytologischen Befund interpretiert.

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Otitis externa und media bei Hund und Katze

Cited by 10 publications

References 77 publications

Determination of minimum inhibitory concentrations for silver sulfadiazine and other topical antimicrobial agents against strains of Pseudomonas aeruginosa isolated from canine otitis externa

Determination of minimum inhibitory concentrations for silver sulfadiazine and other topical antimicrobial agents against strains of Pseudomonas aeruginosa isolated from canine otitis externa

Ceruminal diffusion activities and ceruminolytic characteristics of otic preparations – an in-vitro study

Vergleich von vier zytologischen Färbeverfahren für Ohrabstriche beim Hund

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