Other Significant Haemoglobinopathies

Bain, Barbara J.

doi:10.1002/9780470988787.ch5

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Haemoglobinopathy Diagnosis 2006

DOI: 10.1002/9780470988787.ch5

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Other Significant Haemoglobinopathies

Barbara J. Bain¹

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Cited by 6 publications

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Reconfirming HPLC-Detected Abnormal Haemoglobins by a Second Independent Technique: A Judicious Approach

Khunger

Chopra

Arora

et al. 2014

Indian J Hematol Blood Transfus

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Hb HPLC is an important tool in the diagnosis of various haemoglobinopathies. However, in some cases, it has its diagnostic limitations, when used alone and it is judicious to reconfirm by a second independent technique, as per current guidelines [1]. To illustrate this, we are presenting two cases of haemoglobinopathies reported in Haematology Department of a tertiary care hospital.In one case (Case 1), a 24 years old North Indian Punjabi female presented in our Haematology Lab for routine antenatal Hb HPLC referred by Obstetrics and Gynaecology Department her Hb analysis by HPLC demonstrated HbF (0.7 %), HbA 0 (49.8 %) and a variant Hb (43.1 %) in the HbA 2 window with a retention time of 3.62 min (Fig. 1). Her Hb was 11.8 Gm%, RBC indices were normal and blood picture was normocytic normochromic.In another case (Case 2), a 26 years old North Indian Punjabi male, presented for routine Hb HPLC. His Hb analysis by HPLC demonstrated HbF (0.7 %), HbA 0 (49.8 %) and a variant Hb (42.1 %) in the HbA 2 window with a retention time of 3.62 min. His Hb was 15.4 Gm% with normal red cell indices and normocytic normochromic blood picture.The haemoglobins which can elute by HPLC in the HbA 2 window with the retention time range of 3.3-3.9 min are HbA 2

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Reconfirming HPLC-Detected Abnormal Haemoglobins by a Second Independent Technique: A Judicious Approach

Khunger

Chopra

Arora

et al. 2014

Indian J Hematol Blood Transfus

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Characterization of a Double Heterozygote HbE/β+ Thalassemia IVS 1-1 [G>T] in a Juvenile Diabetic

Bhat

Lokeshwarappa

Mandal³

2014

Ind J Clin Biochem

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Double heterozygosity hemoglobin S, C or D and beta thalassemia in a series of three cases

Molina-Arrebola¹,

Alba-Sosa²,

Ruiz-Cara³

et al. 2020

Rev Med Lab

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Other Significant Haemoglobinopathies

Cited by 6 publications

References 104 publications

Reconfirming HPLC-Detected Abnormal Haemoglobins by a Second Independent Technique: A Judicious Approach

Reconfirming HPLC-Detected Abnormal Haemoglobins by a Second Independent Technique: A Judicious Approach

Characterization of a Double Heterozygote HbE/β+ Thalassemia IVS 1-1 [G>T] in a Juvenile Diabetic

Double heterozygosity hemoglobin S, C or D and beta thalassemia in a series of three cases

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