Learning Objectives: On successful completion of this activity, participants should be able to (1) define prognostic and predictive imaging biomarkers and name at least 1 prognostic and predictive imaging biomarker for advanced breast cancer; (2) list the current roles of 18 F-FDG PET/CT imaging in advanced breast cancer; and (3) list 3 non-18 F-FDG radiotracers that may serve as imaging biomarkers in advanced breast cancer.