Other Neurological Disorders Associated With Gastrointestinal, Liver, or Pancreatic Diseases

Chaudhry, Vinay; Ravich, William J.

doi:10.1016/b978-044306707-5.50018-3

Cited by 6 publications

(8 citation statements)

References 70 publications

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“…The patient was put on a GFD, resolving the gastrointestinal symptoms and also reaching almost complete resolution of the pseudotumour cerebri symptoms. Neurological signs are rare in children but as many as 36 % of adult patients present neurological changes (77) . Other neurological manifestations are tremor, myelopathy, brainstem encephalitis, progressive leukoencephalopathy, vasculitis, occipital calcification and myoclonic syndrome.…”

Section: Neurological Complications and Cognitive Impairment In Coelimentioning

confidence: 99%

The progression of coeliac disease: its neurological and psychiatric implications

et al. 2016

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The aim of the paper is to show the various neurological and psychiatric symptoms in coeliac disease (CD). CD is a T cell-mediated, tissuespecific autoimmune disease which affects genetically susceptible individuals after dietary exposure to proline-and glutamine-rich proteins contained in certain cereal grains. Genetics, environmental factors and different immune systems, together with the presence of auto-antigens, are taken into account when identifying the pathogenesis of CD. CD pathogenesis is related to immune dysregulation, which involves the gastrointestinal system, and the extra-intestinal systems such as the nervous system, whose neurological symptoms are evidenced in CD patients. A gluten-free diet (GFD) could avoid cerebellar ataxia, epilepsy, neuropathies, migraine and mild cognitive impairment. Furthermore, untreated CD patients have more symptoms and psychiatric co-morbidities than those treated with a GFD. Common psychiatric symptoms in untreated CD adult patients include depression, apathy, anxiety, and irritability and schizophrenia is also common in untreated CD. Several studies show improvement in psychiatric symptoms after the start of a GFD. The present review discusses the state of the art regarding neurological and psychiatric complications in CD and highlights the evidence supporting a role for GFD in reducing neurological and psychiatric complications.

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Section: Neurological Complications and Cognitive Impairment In Coelimentioning

confidence: 99%

The progression of coeliac disease: its neurological and psychiatric implications

et al. 2016

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“…Recently, there are several hypotheses about gluten toxic damage and vitamin malabsorption. [4,5] Neuropathy in CeD patients presumably mediated in part by antiganglioside antibodies or by antibodies that target transglutaminase bound to extracellular proteins such as fibronectin. However, these mechanisms have not yet been established [12,13].…”

Section: Discussionmentioning

confidence: 99%

“…[2,3] Other neurological manifestations are epilepsy, cognitive disorders, dementia, tremor, myelopathy, neuropathy, brainstem encephalitis, progressive leukoencephalopathy, vasculitis, occipital calcification, anxiety/depression, and myoclonic syndrome. They also include neuromuscular manifestation such as peripheral polyneuropathy, mononeuropathy multiplex, dermatomyositis, polymyositis, and inclusion body myositis [4].…”

Section: Introductionmentioning

confidence: 99%

Celiac Disease Associated with Facioscapulohumeral Muscular Dystrophy

Kocsis

Herszényi

Tóth

et al. 2016

IJCD

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Introduction. The association of celiac disease and facioscapulohumeral muscular dystrophy was not reported earlier in the literature. Case presentation. A 35-year-old woman diagnosed clinically with facioscapulohumeral muscular dystrophy 23 years ago. In the family history patients' mother was diagnosed with facioscapulohumeral muscular dystrophy, too. Physical examination revealed bilateral facial weakness, she had narrow smile and murmuring speech. She had low-degree atrophy of shoulder girdle muscles with left-dominated scapular winging. facioscapulohumeral muscular dystrophy DNA testing showed allele 1 deletion. From 2001 on, patient presented epigastrial pain, diarrhoea, weight loss. She had permanent fatigue and she was unable to do regular physical exercises, which led to the progression of muscular dystrophy. Since serological examination detected elevated tissue transglutaminase and deaminated gliadin peptide antibodies levels, and duodenal biopsy revealed subtotal villous atrophy. Celiac disease was diagnosed. She started strict gluten free diet. After 3 months of gluten free diet, patient reported the elimination of gastrointestinal symptoms, better general condition, weight gain and increased muscle strength. Conclusion. Appropriate nutrition is essential for facioscapulohumeral muscular dystrophy patients, therefore detection and treatment of any disorders leading to malabsorption, most commonly celiac disease, are of utmost importance.

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“…On the other hand, the peripheral nervous system involvement includes different types of peripheral neuropathies and muscular involvement. These presentations are uncommon in children but this prevalence in adult patients is as many as 36% [125].GFD is recommended for the patients with clinically, serologically, and histologically confirmed CD. There is a great controversy about the administration of GFD in the patients with neurological manifestations, without gastrointestinal presentation, and confirmed pathological evidence of CD in distal duodenal biopsy.…”

Section: Discussionmentioning

confidence: 99%

Neurological Manifestations of Celiac Disease

Pishva

Haghighi

Ashkani-Esfahani

et al. 2013

GMJ

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Celiac disease (CD) is a rare malabsorption syndrome mainly occurring in childhood which is now recognized as the most common food intolerance disease in the world. CD is associated with a wide spectrum of extra intestinal manifestations. Neurological involvements of CD were first attributed to malabsorption due to changes in the mucosal architecture of the small intestine. Neurological manifestations were more frequent in middle-aged adults, but were rare in children. The most common central nervous system manifestations include cerebellar malfunctions, seizures, dementia, multiple sclerosis like presentations, motor neuron diseases, headaches, movement disorders, and neuro-psychiatric presentations. On the other hand, the peripheral nervous system involvement includes different types of peripheral neuropathies and muscular involvements. In this study, we embarked on a short review to go through the neurological presentations and problems of CD.

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Other Neurological Disorders Associated With Gastrointestinal, Liver, or Pancreatic Diseases

Cited by 6 publications

References 70 publications

The progression of coeliac disease: its neurological and psychiatric implications

The progression of coeliac disease: its neurological and psychiatric implications

Celiac Disease Associated with Facioscapulohumeral Muscular Dystrophy

Neurological Manifestations of Celiac Disease

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