Other Cyanobacterial Bioactive Substances

Eleršek, Tina; Bláha, Luděk; Mazur‐Marzec, Hanna; Schmidt, W.; Carmeli, Shmuel

doi:10.1002/9781119068761.ch19

Cited by 8 publications

(11 citation statements)

References 92 publications

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“…ANA B and ANA F, the most frequently found ANAs, were shown to inhibit the growth of many M. aeruginosa strains by inducing the lytic cycle in cyanobacteria [70,71]. Taking into account the published effects of these metabolites, its ecological roles might be important [72].…”

Section: Discussionmentioning

confidence: 99%

“…MGs are zinc metalloprotease inhibitors (e.g., angiotensin-converting enzyme), and aminoproteinases that bind their α-hydroxy-β-amino residue to the zinc at the active site of the enzyme. Our findings indicate that these substances are important candidates for treating hypertension [72]. The patchy distribution of oligopeptide patterns in cyanobacterial populations enables classifying isolates into several oligopeptide-based chemotypes [14,75].…”

Section: Discussionmentioning

confidence: 99%

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Microcystis Chemotype Diversity in the Alimentary Tract of Bigheaded Carp

Riba

Kiss‐Szikszai

Gonda

et al. 2019

Toxins

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Most cyanobacterial organisms included in the genus Microcystis can produce a wide repertoire of secondary metabolites. In the mid-2010s, summer cyanobacterial blooms of Microcystis sp. occurred regularly in Lake Balaton. During this period, we investigated how the alimentary tract of filter-feeding bigheaded carps could deliver different chemotypes of viable cyanobacteria with specific peptide patterns. Twenty-five Microcystis strains were isolated from pelagic plankton samples (14 samples) and the hindguts of bigheaded carp (11 samples), and three bloom samples were collected from the scums of cyanobacterial blooms. An LC-MS/MS-based untargeted approach was used to analyze peptide patterns, which identified 36 anabaenopeptin, 17 microginin, and 13 microcystin variants. Heat map clustering visualization was used to compare the identified chemotypes. A lack of separation was observed in peptide patterns of Microcystis that originated from hindguts, water samples, and bloom-samples. Except for 13 peptides, all other congeners were detected from the viable and cultivated chemotypes of bigheaded carp. This finding suggests that the alimentary tract of bigheaded carps is not simply an extreme habitat, but may also supply the cyanobacterial strains that represent the pelagic chemotypes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Microcystis Chemotype Diversity in the Alimentary Tract of Bigheaded Carp

Riba

Kiss‐Szikszai

Gonda

et al. 2019

Toxins

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“…In addition to these three major groups of cyanotoxins, i.e., hepatotoxins, neurotoxins and cytotoxins, there is abundant toxicological evidence for further unidentified cyanobacterial bioactive/toxic compounds in aquatic ecosystems in Europe (Elersek et al, 2017). Besides new toxins and indications of a widening occurrence of known toxins, future research may reveal new environments affected with toxic/noxious cyanobacteria and their toxins.…”

Section: Occurrence Of Cyanobacteria and Cyanotoxins And Methods Formentioning

confidence: 99%

Toxic cyanobacteria and cyanotoxins in European waters – recent progress achieved through the CYANOCOST Action and challenges for further research

et al. 2017

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This review aims to summarise the outcomes of some recent European research concerning toxic cyanobacteria and cyanotoxins, with an emphasis on developments within the framework of the CYANOCOST Action: COST Action ES1105, Cyanobacterial Blooms and Toxins in Water Resources: Occurrence, Impacts and Management. Highlights of the Action include phycological and ecological studies, development of advanced techniques for cyanotoxin analysis, elucidation of cyanotoxin modes of action, management techniques to reduce cyanobacterial mass development, and research on methods and practices for cyanotoxin removal during drinking water treatment. The authors have identified a number of gaps in knowledge. Proposed directions for future research on toxic cyanobacteria and cyanotoxins are also discussed.

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“…Assessment of Lyngbya majuscula ( Moorea producens ) has shown that this marine cyanobacterium is capable of producing a wide range of bioactive compounds with unusual and unique toxicological actions [ 81 ]. A number of lipopeptides that contain an aliphatic group can be produced by cyanobacteria and are capable of affecting voltage gated sodium channels on neurons.…”

Section: Toxins That Affect the Brain And Nervesmentioning

confidence: 99%

Cyanotoxins and the Nervous System

Metcalf

Tischbein

Cox

et al. 2021

Toxins

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Cyanobacteria are capable of producing a wide range of bioactive compounds with many considered to be toxins. Although there are a number of toxicological outcomes with respect to cyanobacterial exposure, this review aims to examine those which affect the central nervous system (CNS) or have neurotoxicological properties. Such exposures can be acute or chronic, and we detail issues concerning CNS entry, detection and remediation. Exposure can occur through a variety of media but, increasingly, exposure through air via inhalation may have greater significance and requires further investigation. Even though cyanobacterial toxins have traditionally been classified based on their primary mode of toxicity, increasing evidence suggests that some also possess neurotoxic properties and include known cyanotoxins and unknown compounds. Furthermore, chronic long-term exposure to these compounds is increasingly being identified as adversely affecting human health.

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Other Cyanobacterial Bioactive Substances

Cited by 8 publications

References 92 publications

Microcystis Chemotype Diversity in the Alimentary Tract of Bigheaded Carp

Microcystis Chemotype Diversity in the Alimentary Tract of Bigheaded Carp

Toxic cyanobacteria and cyanotoxins in European waters – recent progress achieved through the CYANOCOST Action and challenges for further research

Cyanotoxins and the Nervous System

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