This research aims to examine the relationship between transformational leadership and employee voice, and the mediating role of thriving at work, and the moderating role of work alienation in this relationship. Data were obtained from 402 employees working at the AssisTT Call Center in Erzincan province by survey method. As a result of the analyses, a significant and positive relationship was found between transformational leadership and employee voice. In addition, it was determined that thriving at work has a partial mediating role, and work alienation has a moderating role in this relationship. In the literature, there is no previous study examining the mediating and moderating roles in question. In this context, it is considered that this study will constitute a significant resource for future studies in the field. Also, the research has some limitations. Firstly, pre-prepared questionnaires were used in the research, and the correlations between the variables were assessed in this setting. In addition, the data were obtained with the cross-sectional method. Finally, the study was limited to a single location and employees from a particular industry (communication). Future studies may conduct more thorough research with participants from various provinces and sectors through the longitudinal method.