Osthole stimulates bone formation, drives vascularization and retards adipogenesis to alleviate alcohol‐induced osteonecrosis of the femoral head

Yu, Hongping; Zhu, Daoyu; Liu, Pei; Yang, Qianhao; Gao, Junjie; Huang, Yigang; Chen, Yixuan; Gao, You-Shui; Zhang, Changqing

doi:10.1111/jcmm.15103

Cited by 27 publications

(20 citation statements)

References 56 publications

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“…Initially, we identified that the cell activity and osteogenic differentiation capacity of BMSCs had decreased in ONFH rats. A previous study has reported the decreased osteogenic differentiation and the expand of adipocytes deposition in bone marrow of ONFH 24 . There are many potential capacities in BMSCs such as the promotion of osteogenesis 25 .…”

Section: Discussionmentioning

confidence: 93%

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microRNA‐148a‐3p in extracellular vesicles derived from bone marrow mesenchymal stem cells suppresses SMURF1 to prevent osteonecrosis of femoral head

Huang

et al. 2020

J Cellular Molecular Medi

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Section: Discussionmentioning

confidence: 93%

“…A previous study has reported the decreased osteogenic differentiation and the expand of adipocytes deposition in bone marrow of ONFH. 24 There are many potential capacities in BMSCs such as the promotion of osteogenesis. 25 Moreover, BMSCs can be used to treat ONFH in the region of osteonecrosis.…”

Section: Discussionmentioning

confidence: 99%

microRNA‐148a‐3p in extracellular vesicles derived from bone marrow mesenchymal stem cells suppresses SMURF1 to prevent osteonecrosis of femoral head

Huang

et al. 2020

J Cellular Molecular Medi

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“…14 Our previous studies have indicated that muscone, cordycepin and osthole have beneficial effects for ONFH. [15][16][17] CPA, also known as chrysophanol and 1,8-dihydroxy-3-methyl-anthraquinone, can be extracted from various herbs, including Rumex crispus, Polygonum multiflorum and Cassia obtusifolia. 18,19 CPA has been revealed to possess many beneficial pharmacological effects, such as lipid regulation, neuroprotection, anti-cancer, anti-inflammation, hepatoprotection and anti-obesity function.…”

mentioning

confidence: 99%

Chrysophanic acid shifts the differentiation tendency of BMSCs to prevent alcohol‐induced osteonecrosis of the femoral head

Liu

Zhu

et al. 2020

Cell Proliferation

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Objectives Osteonecrosis of the femoral head (ONFH), largely caused by alcohol abuse, is a refractory bone disease characterized by the impaired capacity of osteogenic differentiation of bone mesenchymal stem cells (BMSCs), as well as the disordered adipocyte accumulation. Chrysophanic acid (CPA) is a natural anthraquinone which has lipid regulation and bone protection capacity. The aim of this study was to reveal the potential function of CPA and the underlying mechanisms for the alcohol‐induced ONFH. Materials and Methods The effects of alcohol and CPA on BMSCs were investigated by cell proliferation, induced differentiation assays and immunofluorescent staining. Meanwhile, the function of PI3K/AKT and AMPK pathway was investigated in the process of osteogenic and adipogenic differentiation, respectively. Furthermore, we established the rat model of alcohol‐induced ONFH to reveal the pharmacotherapeutic effect of CPA in vivo using radiographical and histopathological methods. Results In vitro, alcohol significantly inhibited the proliferation and osteogenic differentiation of BMSCs but stimulated the adipogenic differentiation. However, CPA could counteract the anti‐osteogenesis of alcohol partly via PI3K/AKT pathway and retard the promotion of alcohol‐induced adipogenesis via AMPK pathway. In vivo, radiographical and histopathological findings showed that CPA could alleviate alcohol‐induced ONFH and substantially restore the bone volume. Conclusions We demonstrated that CPA ameliorated alcohol‐induced ONFH possibly via regulating the differentiation tendency of BMSCs. Hence, CPA may become a beneficial herb extract to alleviate alcohol‐induced ONFH.

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“…To a certain extent, it can explain the efficacy of ESWT in treating BMES caused by trauma in this study. Ethanol can significantly reduce the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells [ 36 ], which is one of the pathogenesis factors of ONFH. ESWT significantly promoted bone morphogenic protein (BMP)-2, BMP-3, BMP-4, and BMP-7 mRNA expression in the callus [ 5 ], and BMP is essential for fracture healing.…”

Section: Discussionmentioning

confidence: 99%

Extracorporeal shock wave therapy for bone marrow edema syndrome in patients with osteonecrosis of the femoral head: a retrospective cohort study

et al. 2021

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Background There is now ample evidence suggesting that extracorporeal shock wave therapy (ESWT) can improve hip mobility and reduce pain in patients with osteonecrosis of the femoral head (ONFH). The ability of ESWT to cure bone marrow edema syndrome (BMES) in patients with ONFH, 12 weeks after the initial course of ESWT, needs to be verified further and more relevant clinical research-based evidence should be consolidated. This study aimed to evaluate the efficacy of ESWT for BMES caused by ONFH. Methods This retrospective cohort study included 67 patients with BMES caused by ONFH who were participating in a rehabilitation program as outpatients. Before and after ESWT, the area of femoral bone marrow edema was evaluated by magnetic resonance imaging (MRI), and the Harris score and Charnley score were evaluated as hip pain and function indicators. Results After ESWT, MRI revealed that the area of bone marrow edema decreased from 984.6 ± 433.2 mm2 to 189.7 ± 214.4 mm2 (P < 0.0001). The Harris score increased from 42.2 ± 9.1 to 77.7 ± 10.8 points (P < 0.0001). The Charnley score increased from 7.3 ± 1.4 to 12.0 ± 1.7 (P < 0.0001). ESWT was effective in treating BMES in 98.5% of the cases. Conclusions This study demonstrated that ESWT can effectively treat BMES caused by ONFH and can aid in pain relief and functional recovery in patients with ONFH. Thus, ESWT should be included in the classic physical therapy regimen for patients with ONFH and BMES.

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Osthole stimulates bone formation, drives vascularization and retards adipogenesis to alleviate alcohol‐induced osteonecrosis of the femoral head

Cited by 27 publications

References 56 publications

microRNA‐148a‐3p in extracellular vesicles derived from bone marrow mesenchymal stem cells suppresses SMURF1 to prevent osteonecrosis of femoral head

microRNA‐148a‐3p in extracellular vesicles derived from bone marrow mesenchymal stem cells suppresses SMURF1 to prevent osteonecrosis of femoral head

Chrysophanic acid shifts the differentiation tendency of BMSCs to prevent alcohol‐induced osteonecrosis of the femoral head

Extracorporeal shock wave therapy for bone marrow edema syndrome in patients with osteonecrosis of the femoral head: a retrospective cohort study

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