Osthole impairs mitochondrial metabolism and the autophagic flux in colorectal cancer

Song, Jisoo; Ham, Jiyeon; Park, Wonhyoung; Song, Gwonhwa; Lim, Whasun

doi:10.1016/j.phymed.2024.155383

Cited by 1 publication

(2 citation statements)

References 58 publications

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“…Studies have demonstrated several physiological effects of osthole, including its anti-inflammatory properties [ 120 ]. Osthole efficiently inhibits the proliferation of colorectal cancers and mitigates intestinal damage generated by AOM/DSS [ 121 ]. Osthole enhances the functionality of goblet cells and inhibits the expression of Claudin1 and Axin1, which are disrupted by AOM/DSS.…”

Section: Novel Therapeutical Aspects Of Epigenetic- and Autophagy-rel...mentioning

confidence: 99%

“…Additionally, studies have demonstrated that the combination of chloroquine and osthole disrupts the autophagy flux, leading to the programmed cell death of HCT116 and HT29 colon cancer cells. Furthermore, studies have clarified that the osthole-controlled functional role of tiRNAHisGTG directly influences the cellular destiny of colon cancer cells [ 121 ]. These findings indicate that osthole has the capacity to control the advancement of CRC by controlling the signal transmission of autophagy-inflammasome-mediated processes.…”

Section: Novel Therapeutical Aspects Of Epigenetic- and Autophagy-rel...mentioning

confidence: 99%

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Inflammasomes Are Influenced by Epigenetic and Autophagy Mechanisms in Colorectal Cancer Signaling

Műzes,

Sipos

2024

IJMS

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Inflammasomes contribute to colorectal cancer signaling by primarily inducing inflammation in the surrounding tumor microenvironment. Its role in inflammation is receiving increasing attention, as inflammation has a protumor effect in addition to inducing tissue damage. The inflammasome’s function is complex and controlled by several layers of regulation. Epigenetic processes impact the functioning or manifestation of genes that are involved in the control of inflammasomes or the subsequent signaling cascades. Researchers have intensively studied the significance of epigenetic mechanisms in regulation, as they encompass several potential therapeutic targets. The regulatory interactions between the inflammasome and autophagy are intricate, exhibiting both advantageous and harmful consequences. The regulatory aspects between the two entities also encompass several therapeutic targets. The relationship between the activation of the inflammasome, autophagy, and epigenetic alterations in CRC is complex and involves several interrelated pathways. This article provides a brief summary of the newest studies on how epigenetics and autophagy control the inflammasome, with a special focus on their role in colorectal cancer. Based on the latest findings, we also provide an overview of the latest therapeutic ideas for this complex network.

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Section: Novel Therapeutical Aspects Of Epigenetic- and Autophagy-rel...mentioning

confidence: 99%

Section: Novel Therapeutical Aspects Of Epigenetic- and Autophagy-rel...mentioning

confidence: 99%

Inflammasomes Are Influenced by Epigenetic and Autophagy Mechanisms in Colorectal Cancer Signaling

Műzes,

Sipos

2024

IJMS

View full text Add to dashboard Cite

show abstract

Osthole impairs mitochondrial metabolism and the autophagic flux in colorectal cancer

Cited by 1 publication

References 58 publications

Inflammasomes Are Influenced by Epigenetic and Autophagy Mechanisms in Colorectal Cancer Signaling

Inflammasomes Are Influenced by Epigenetic and Autophagy Mechanisms in Colorectal Cancer Signaling

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