Osteotropic Polypeptide Nanoparticles with Dual hydroxyapatite Binding Properties and Controlled Cisplatin Delivery

Miguel, Laura De; Popa, Iuliana; Noiray, Magali; Caudron, Éric; Arpinati, Ludovica; Desmaële, Didier; Cebrián‐Torrejón, Gerardo; Doménech‐Carbó, Antonio; Ponchel, Gilles

doi:10.1007/s11095-014-1576-z

Cited by 10 publications

(4 citation statements)

References 35 publications

(46 reference statements)

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“…Therefore, recent research on HA bioceramics focused on producing multifunctional materials, which, in addition to being used as scaffolds for growing tissue, could also release drugs directly into the bone in the affected area [14]. The literature describes research on HA as a delivery system for antiresorptive (e.g., bisphosphonates) and anticancer drugs (e.g., doxorubicin and cisplatin), as well as antibiotics mainly against perioperative and intraoperative infections [15][16][17].…”

Section: −mentioning

confidence: 99%

Hydroxyapatite-Based Materials for Potential Use in Bone Tissue Infections

Szurkowska¹,

Laskus²,

Kolmas³

2018

Hydroxyapatite - Advances in Composite Nanomaterials, Biomedical Applications and Its Technological Facets

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Hydroxyapatite materials, due to their high biocompatibility, play a crucial role in orthopaedics and bone surgery as alternatives to autologous bone grafts. It was also found that coatings of metallic implants with hydroxyapatite layer improve significantly their osseointegration. Due to its bioactivity, osteoconductivity and non-toxicity, hydroxyapatite is also widely used as a component of hybrid biomaterials. The implantation of "foreign" materials brings one major concern that is the risk of potential bone tissue infections or chronic osteomyelitis. In turn, the main problem concerning bacterial infection treatment is to obtain an adequate, bactericidal drug concentration maintained for a sufficient period of time in the bone tissue. Therefore, recent developments of materials engineering are focused on delivery antibiotics directly into the affected bone. To achieve this goal, hydroxyapatite-based materials are frequently studied as carriers for antibacterial drugs. For effective support of antibiotic therapy, the antibacterial activity of certain ions (including silver, zinc or copper) may be applied. In our work, we present recent developments on ceramic materials for bacterial bone infections: hydroxyapatite-based carriers for antibiotics and modifications of hydroxyapatite with antibacterial ions. In this review, state-of-the-art and current applications of such materials are presented and discussed. We want to also present our recent results.

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Section: −mentioning

confidence: 99%

Hydroxyapatite-Based Materials for Potential Use in Bone Tissue Infections

Szurkowska¹,

Laskus²,

Kolmas³

2018

Hydroxyapatite - Advances in Composite Nanomaterials, Biomedical Applications and Its Technological Facets

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“…For P(L‐Glu‐Bz)‐P(L‐Glu) conjugates with CDDP, the polymer and the conjugate adopted ellipsoidal shapes (aspect ratio of 1.3, 37 ± 7 nm × 27 ± 6 nm) with a hydrodynamic diameter of 49–58 nm. The authors observed no significant changes in the morphology with CDDP loading up to 8.3% …”

Section: Physico‐chemical Properties Driving the Bio‐nano Interfacementioning

confidence: 99%

Polypeptide‐Based Conjugates as Therapeutics: Opportunities and Challenges

Zagorodko

Arroyo‐Crespo

Nebot

et al. 2016

Macromolecular Bioscience

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Synthetic polypeptides or polyamino acids have become a useful and multifunctional platform in advanced drug delivery studies. Nonetheless, the full potential of these systems has yet to be achieved. The final structure of polypeptide conjugates and their in vivo behavior are dependent on an extraordinarily complex pattern of interconnected physico-chemical and structural parameters, making sophisticated directional design of such systems difficult and often unachievable. In this review, the authors aim to discuss the role of these parameters in the successful design of different drug delivery architectures and to delineate some basic correlations between structure, properties, and the biological behavior of polypeptide-based conjugates.

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“…The in vitro drug release studies showed that physiological concentrations of chloride ions triggered cisplatin release with a near zero‐order kinetics profile over 14 days 187 . The high affinity binding of cisplatin‐loaded PBLG‐b‐PGlu NPs to calcified matrix was also approved by an in vitro HA binding assay 187 …”

Section: Targeted Drug Delivery Systemsmentioning

confidence: 99%

Targeted nanomedicines for the treatment of bone disease and regeneration

Ordikhani

Zandi

Mazaheri

et al. 2020

Medicinal Research Reviews

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Targeted delivery by either passive or active targeting of therapeutics to the bone is an attractive treatment for various bone related diseases such as osteoporosis, osteosarcoma, multiple myeloma, and metastatic bone tumors. Engineering novel drug delivery carriers can increase therapeutic efficacy and minimize the risk of side effects. Developmnet of nanocarrier delivery systems is an interesting field of ongoing studies with opportunities to provide more effective therapies. In addition, preclinical nanomedicine research can open new opportunities for preclinical bone‐targeted drug delivery; nevertheless, further research is needed to progress these therapies towards clinical applications. In the present review, the latest advancements in targeting moieties and nanocarrier drug delivery systems for the treatment of bone diseases are summarized. We also review the regeneration capability and effective delivery of nanomedicines for orthopedic applications.

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Osteotropic Polypeptide Nanoparticles with Dual hydroxyapatite Binding Properties and Controlled Cisplatin Delivery

Abstract: These properties suggest the potential utility of cisplatin-loaded PBLG-b-PGlu nanoparticles as carrier systems for the treatment of bone metastases.

Cited by 10 publications

References 35 publications

Hydroxyapatite-Based Materials for Potential Use in Bone Tissue Infections

Hydroxyapatite-Based Materials for Potential Use in Bone Tissue Infections

Polypeptide‐Based Conjugates as Therapeutics: Opportunities and Challenges

Targeted nanomedicines for the treatment of bone disease and regeneration

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