Osteosarcopenia in Patients with Hip Fracture Is Related with High Mortality

Yoo, Jun Il; Kim, Hyunho; Ha, Yong‐Chan; Kwon, Hyuck Bin; Koo, Kyung Hoi

doi:10.3346/jkms.2018.33.e27

Cited by 123 publications

(109 citation statements)

References 22 publications

(22 reference statements)

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“…is difference may be due to the fact that their cohort included only men, while in this study, the majority was women, who have shown to have a higher prevalence of muscle mass loss [9]. Another study showed a prevalence of osteosarcopenia of 27% and sarcopenia of 10% [4]. Something more similar to our study was seen in the study by Yoo et al [21] where the reported prevalence of sarcopenia was 44% in women and 68% in men who had had a previous fracture.…”

Section: Discussionmentioning

confidence: 57%

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Bone Mass Loss and Sarcopenia in Ecuadorian Patients

Intriago

Maldonado

Guerrero

et al. 2020

Journal of Aging Research

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Introduction. An intimate relationship between osteoporosis and sarcopenia has been established. At present, there are few epidemiological studies about osteosarcopenia due to the recent use of this term, especially in Latin America. Objective. To study the association between osteoporosis and sarcopenia and determine the prevalence of osteosarcopenia in patients who attended a rheumatology center in Ecuador. Methods. A cross-sectional study was conducted in a population of patients who had a densitometric study. The diagnosis of sarcopenia was determined by the DXA standard gold test, screening, and conventional methods (bioimpedance, anthropometric measurements, SARC-F, muscle function, and gait test). Results. A total of 92 patients were studied. The median age was 66 ± 10, 90% females. Using the criteria of SMI, 65% had sarcopenia of which 9% had only sarcopenia and 56% had osteosarcopenia; 22% had only osteopenia/osteoporosis; and 13% none of these conditions. The prevalence of sarcopenia according to handgrip strength was 60%, gait speed 45%, and SARC-F score 40%. The prevalence of osteosarcopenia according to handgrip strength was 51%, gait speed 34%, and SARC-F score 32%. Osteoporosis was associated with a higher prevalence of sarcopenia using the criteria of SMI since 40% had sarcopenia in the normal DXA group, 64% in the osteopenia group, and 76% in the osteoporosis group (p=0.017). Of the women, 69% had sarcopenia compared to 33% of the men (p=0.034). The BMI was lower in the group with sarcopenia (25.1 ± 4.1 kg/m2) compared to the group without sarcopenia (29.4 ± 4.1 kg/m2, p<0.001). Patients with osteosarcopenia and sarcopenia had lower BMI, handgrip strength, ASM, SMI, and total-body skeletal muscle mass than those with osteopenia/osteoporosis or normal patients. Conclusion. 65% of the studied population had sarcopenia. It is clear that the prevalence of sarcopenia is higher in patients with greater loss of bone mass. Identifying pathways that affect both bone and muscle could facilitate the development of treatments that simultaneously improve osteoporosis and sarcopenia.

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Section: Discussionmentioning

confidence: 57%

“…e term osteosarcopenia was recently proposed to describe the coexistence of both conditions in the same patient [3]. It has been shown that this combination represents an even greater risk of these results than any of the conditions alone [4].…”

Section: Introductionmentioning

confidence: 99%

Bone Mass Loss and Sarcopenia in Ecuadorian Patients

Intriago

Maldonado

Guerrero

et al. 2020

Journal of Aging Research

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“…The prevalence of osteosarcopenia in community‐dwelling older adults ranges from 4.7% in Japan, to 13% in China and 28% in Germany, with the highest rates observed in Australia (40%) and Iran (34%) (N. Fahimfar, unpublished data, June 2019). A study of older Koreans with hip fractures also found that 27.2% were osteosarcopenic . The varied prevalence is likely due to heterogenous populations or a non‐unified diagnostic criterion for this syndrome, with various screening tools being utilized for low muscle mass and function (sarcopenia), a key component of osteosarcopenia.…”

Section: Introductionmentioning

confidence: 99%

Osteosarcopenia: A case of geroscience

2019

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Global aging, attributed to advancements in health care and socioeconomic factors, represents one of the great achievements of the 21st century. However, older age associates with chronic diseases, which could share similar pathophysiology and risk factors; understanding and elucidation of those common mechanisms have enabled the development of geroscience. Musculoskeletal diseases, in particular, represent a significant burden in older persons and a major cost to health systems worldwide. Of those, osteopenia/osteoporosis (characterized by low bone mass) increases with age alongside the number of osteoporotic fractures, 1 while sarcopenia (low muscle mass and function) confers a high risk of falls and disability in older persons. 2 Together, these diseases form a geriatric syndrome known as "osteosarcopenia," 3 which associates with an increased risk of falls, fractures, and hospitalizations in older persons. 4,5 Not only does osteosarcopenia induce billions in health-care expenditure but it also greatly impairs an older person's quality of life. 3,6

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“…A study of Chinese adults (≥65 years old) identified osteosarcopenia in 10.4% of men and 15.1% of women, with higher odds of frailty in the osteosarcopenics, relative to osteopororic or sarcopenic patients alone (55). In patients with hip fractures and osteosarcopenia, the 1-year mortality rate was 15.1%, compared to 5.1% for osteoporotic or 10.3% for sarcopenic patients (56). Future therapies could embrace both osteoporosis and sarcopenia by targeting pathways that affect both muscle and bone.…”

Section: Osteosarcopeniamentioning

confidence: 99%

MECHANISMS OF ENDOCRINE DISEASE: Sarcopenia in endocrine and non-endocrine disorders

Borba

Costa

Moreira

et al. 2019

European Journal of Endocrinology

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Objective This paper reviews the main mechanisms, diagnostic criteria, treatment options and available data on sarcopenia in endocrine and non-endocrine disorders. The literature notes the presence of sarcopenia as a comorbid condition or a complication of another clinical situation and not a disease that only affects elderly patients. Method We performed a literature review, focusing on the following: mechanisms related to sarcopenia in elderly patients, and sarcopenia as it presents in the context of chronic and endocrine diseases; diagnostic tools and methods; aspects of sarcopenia and treatment options specific to chronic diseases and endocrine disorders respectively. Results Sarcopenia in chronic and endocrine disorders shares many mechanisms with sarcopenia affecting elderly patients, but certain diseases can have a predominant aspect that leads to sarcopenia. The prevalence of sarcopenia varies, depending on different diagnostic criteria, from around 12 to 60% in chronic illnesses and 15 to 90% in endocrine disorders. The interplay between sarcopenia, chronic diseases and elderly patients requires further study, to clarify the impact of each, in terms of prognosis and mortality. Conclusion Awareness of the presentation of sarcopenia in the context of other diseases and ages (and not just the elderly) is fundamental to ensure that preventive measures can be deployed.

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Osteosarcopenia in Patients with Hip Fracture Is Related with High Mortality

Cited by 123 publications

References 22 publications

Bone Mass Loss and Sarcopenia in Ecuadorian Patients

Bone Mass Loss and Sarcopenia in Ecuadorian Patients

Osteosarcopenia: A case of geroscience

MECHANISMS OF ENDOCRINE DISEASE: Sarcopenia in endocrine and non-endocrine disorders

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