Osteosarcoma of the sternum

Douglas, Yvonne L.; Meuzelaar, Koos J.; Lei, Berend van der; Pras, Betty; Hoekstra, Harald J.

doi:10.1016/s0748-7983(97)80153-9

Cited by 13 publications

(10 citation statements)

References 12 publications

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“…Plasmacytomas tend to have hypointense signal on T1-weighted images and hyperintense signal on T2-weighted images (74). Osteosarcoma.-Sternal osteosarcoma, in comparison with osteosarcoma of the extremities, is more commonly reported in older patients (median age, 42 years) (82,83). A significant percentage of sternal osteosarcomas are secondary lesions found in patients who previously underwent radiation therapy (83).…”

Section: Metastasesmentioning

confidence: 99%

Imaging Appearances of the Sternum and Sternoclavicular Joints

Restrepo¹,

Martínez²,

Lemos³

et al. 2009

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171

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The sternum and sternoclavicular joints--critical structures of the anterior chest wall--may be affected by various anatomic anomalies and pathologic processes, some of which require treatment. Pectus excavatum and pectus carinatum are common congenital anomalies that are usually benign but may warrant surgical treatment if they cause compression of vital internal structures. By contrast, developmental variants such as the sternal foramen are asymptomatic and do not require further evaluation or treatment. Arthritides of the sternoclavicular joint (osteoarthritis, septic arthritis, and seronegative arthropathies) are common and must be differentiated before an appropriate management method can be selected. The recognition of complications of sternotomy (eg, sternal dehiscence, secondary osteomyelitis) is critical to avoid life-threatening sequelae such as acute mediastinitis. Likewise, the detection of sternal fractures and sternoclavicular dislocations is important, especially where they impinge on vital structures. In addition, sternal malignancies (most commonly, metastases and chondrosarcoma) must be distinguished from benign neoplasms. To achieve accurate and timely diagnoses that facilitate appropriate treatment, radiologists must be familiar with the appearances of these normal anatomic variants and diseases of the sternum.

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Section: Metastasesmentioning

confidence: 99%

Imaging Appearances of the Sternum and Sternoclavicular Joints

Restrepo¹,

Martínez²,

Lemos³

et al. 2009

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171

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“…A total of 6 cases have been reported, and there is only one case of fibroblastic osteosarcoma reporting the same pathological result as our case. [1,[6][7][8][9] Five of the 6 patients underwent extensive surgical resection with or without neooradjuvant treatment. Only 1 case chose chemoradiotherapy because of distal metastasis.…”

Section: Discussionmentioning

confidence: 99%

Primary fibroblastic osteosarcoma of sternum

Zhou

2022

Medicine

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Rationale:Osteosarcoma, a malignant bone tumor, rarely occurs in the sternum, especially the fibroblastic type, and is associated with poor survival. This case report describes a patient with a neoplasm of the sternum who underwent tumor resection 3 times and reconstruction twice because of the high risk of recurrence.Patient Concerns:A 60-year-old Chinese man presented with a 3-cm palpable bulging mass located in front of his sternum. Chest computed tomography (CT) revealed an anterior chest wall neoplasm with sternal destruction.Diagnosis:Pathological examination revealed that the mass was a low-grade malignant primary fibroblastic osteosarcoma.Interventions:Locking plates were used for chest wall reconstruction, demonstrating good structural stability and economic applicability. Regarding the ineffectiveness of current therapies, whole-exome sequencing was conducted, and no targets matched any of the currently available agents.Outcomes:No recurrence was found on regular reexamination.Lessons:Surgery is the first choice of treatment for patients with primary fibroblastic osteosarcoma of the sternum. The reconstruction-locking plate is a good alternative for chest wall reconstruction. Whole-exome sequencing can shed new light on this uncommon disease and help identify novel therapeutic targets.

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“…Of the primary malignancies of the sternum, chondroblastoma is the most common, making primary osteosarcoma of the sternum a very rare entity [6]. Often, patients will have a history of prior radiation treatment of the chest wall [7].…”

Section: Discussionmentioning

confidence: 99%

Recurrent radiation-induced osteosarcoma of the sternum in a patient with remote radiation therapy for breast cancer

Limback

Letter

Scherer

et al. 2016

Radiology Case Reports

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BackgroundRecurrent radiation-induced osteosarcoma of the sternum following remote radiation therapy for breast cancer and sternal reconstruction.CaseA 51-year-old woman presents with recurrent, radiation-induced sternal osteosarcoma 11 years after receiving both radiation therapy for breast cancer and sternal reconstruction. The case details both her work-up and subsequent course, including reconstructive and curative efforts.DiscussionAn uncommon side effect of radiation therapy for breast cancer is development of osteosarcoma of the chest wall. Even rarer is recurrence of the osteosarcoma following sternal reconstruction.

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Osteosarcoma of the sternum

Cited by 13 publications

References 12 publications

Imaging Appearances of the Sternum and Sternoclavicular Joints

Imaging Appearances of the Sternum and Sternoclavicular Joints

Primary fibroblastic osteosarcoma of sternum

Recurrent radiation-induced osteosarcoma of the sternum in a patient with remote radiation therapy for breast cancer

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