Osteosarcoma of the jaw: report of 3 cases (including the rare epithelioid variant) with review of literature

Malik, Faizan; Gleysteen, John P.; Agarwal, Shweta

doi:10.1016/j.oooo.2020.03.044

Cited by 9 publications

(12 citation statements)

References 41 publications

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“…Other predisposing factors such as ossifying fibroma must be taken into account [7]. In our study we observed the presence of an initial lesion diagnosed as ossifying fibroma that after 5 years debuted as chondroblastic OSJ.…”

Section: Discussionsupporting

confidence: 47%

“…It is identified radiologically as poorly defined lytic lesions with the ability to show a periosteal reaction [38]. The presence of osteoid is a fundamental requirement for its diagnosis, although the amount present can be variable [7]. In our study, two cases were recorded with this morphological pattern in which an extensive neoformation of osteoid in socket was identified in close contact with the tumor cellularity.…”

Section: Discussionmentioning

confidence: 66%

“…Regarding fibroblastic differentiation, there is a greater consensus regarding its lower incidence in OSJ [21,23]. OS of the epithelioid type is a rare variant with only 6 cases published in the jaw region [7,[38][39][40][41][42]. This variant, which was initially described by Scranton et al [43] in 1975, is more prevalent in long bones and in men (2:1), and can present itself between the 1st and 7th decade of life, with a predilection for the mandibular bone.…”

Section: Discussionmentioning

confidence: 99%

“…Unlike the rest of osteosarcomas whose presence is more common in children and adolescents, OSJ affect patients between the 3rd and 4th decade of life [5]. The mandible is the most affected bone in this location [6] and there is no predilection between males and females [7].…”

Section: Introductionmentioning

confidence: 99%

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Clinical and Pathological Features of Osteosarcomas of the Jaws. A Retrospective Study

Rodríguez-Molinero¹,

Pozo‐Kreilinger²,

Ruiz‐Roca³

et al. 2023

Preprint

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Introduction: Osteosarcomas of the jaw (OSJ) are rare tumors with a different behavior from osteosarcomas of other bones. This study aims to analyze the clinical, pathological, and therapeutic characteristics of this type of sarcoma. Methods: a retrospective observational study of cases diagnosed with OSJ registered at the “La Paz” University Hospital (Madrid). Results: Eight cases with a diagnosis of OSJ were obtained in a study period of 22 years (2000-2022). The mean age was 41 years. The distribution was 1:1 between the maxilla and mandible. Painful inflammation was the most frequent clinical manifestation. Conventional osteoblastic osteosarcoma was the most common. Survival at 5 years was 50%, while at 10 years, it decreased to 25%. Conclusions: OSJ differs from conventional osteosarcomas of long tubular bones. Surgery continues to be the mainstay of treatment; more studies are needed in which more standardized protocols can be proposed for adjuvant therapeutic management.

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Section: Discussionsupporting

confidence: 47%

Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical and Pathological Features of Osteosarcomas of the Jaws. A Retrospective Study

Rodríguez-Molinero¹,

Pozo‐Kreilinger²,

Ruiz‐Roca³

et al. 2023

Preprint

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“…A review of the current reveals a general consensus on the prevalence of high-grade OSM, with prevalence rates ranging from 50 to 96% [17,18]. This variability was confirmed by Malik et al [19] in 2020, who reviewed all previous reports describing series of more than 10 patients with OSJ. In a review article, Shah et al reported incidences of about 80% for the high-grade variant and less than 2% for low-grade tumors.…”

Section: Key Pointsmentioning

confidence: 93%

Mandibular osteosarcoma: diagnosis and treatment

Ferri¹,

Bianchi²,

Ferrari

2022

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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Purpose of reviewThis article presents a review of the literature on mandibular osteosarcoma, focusing on the main aspects of its management, including diagnosis, pathology, and treatment. The literature published in the last 5 years was considered but because of the rarity of mandibular osteosarcoma, major publications from the past have also been included. Recent findingsManagement of mandibular osteosarcoma still lacks a clear standard of care, and treatment has not changed markedly over the past several years. The mainstay of treatment is surgical resection with free margins, but chemotherapy has recently begun to play a role in both adjuvant and neoadjuvant settings. SummaryMandibular osteosarcoma is a rare tumor and extensive randomized trials are not available in the international literature. Therefore, the standard of care is not defined, and diagnosis and treatment protocols have been extrapolated from analysis of multiple reports that are often discordant. This makes an interdisciplinary approach mandatory for the management of these patients, to provide the best care possible based on tumor size, site, and patient characteristics.

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Patient with uncontrolled diabetes with a nonpainful, exophytic, purulent mandibular mass

Gates

Tuluc

Gargano

2021

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Osteosarcoma of the jaw: report of 3 cases (including the rare epithelioid variant) with review of literature

Cited by 9 publications

References 41 publications

Clinical and Pathological Features of Osteosarcomas of the Jaws. A Retrospective Study

Clinical and Pathological Features of Osteosarcomas of the Jaws. A Retrospective Study

Mandibular osteosarcoma: diagnosis and treatment

Patient with uncontrolled diabetes with a nonpainful, exophytic, purulent mandibular mass

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