Osteosarcoma of the jaw: an analysis of a series of 74 cases

Paparella, María Luisa; Olvi, Liliana G.; Brandizzi, Daniel; Keszler, Alicia; Santini-Araujo, Eduardo; Cabrini, R. L.

doi:10.1111/his.12191

Cited by 61 publications

(58 citation statements)

References 25 publications

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“…2,15,22 However, one study did find that females diagnosed with JOS may have a worse prognosis. 30 In addition, sex distribution of JOS is a controversial issue, with multiple studies finding that males are more commonly affected owing to a longer period of skeletal growth and additional volume of bone in males. 2,6,9 The data from our present study, to our knowledge the largest JOS study to date show that JOS occurs equally in men and women.…”

Section: Discussionmentioning

confidence: 99%

Characteristics and Prognostic Factors of Osteosarcoma of the Jaws

Lee

Arshi

Schwartz

et al. 2015

JAMA Otolaryngol Head Neck Surg

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Section: Discussionmentioning

confidence: 99%

Characteristics and Prognostic Factors of Osteosarcoma of the Jaws

Lee

Arshi

Schwartz

et al. 2015

JAMA Otolaryngol Head Neck Surg

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“…Even though PMT also contains MNGCs, they are fewer in number and have fewer nuclei [66]. While a similarity between PMT and osteosarcoma is the production of bone, PMT is cytologically bland while osteosarcoma displays cytologic atypia and bone production is variable with many tumors producing some cartilage as well [67]. Folpe also mentioned that PMT comprised only 9 out of over 150,000 mesenchymal tumor consultations seen [61,68].…”

Section: Discussionmentioning

confidence: 99%

Phosphaturic Mesenchymal Tumor: 2 New Oral Cases and Review of 53 Cases in the Head and Neck

Qari

Hamao-Sakamoto

Fuselier

et al. 2015

Head and Neck Pathol

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Phosphaturic mesenchymal tumor (PMT) is a rare neoplasm that secretes fibroblast growth factor-23 (FGF-23) and causes oncogenic osteomalacia. It occurs in adults with equal gender distribution and the most common location is the lower extremities, followed by the head and neck. Besides osteomalacia, the clinical presentation includes bone pain and multiple bone fractures. Microscopic features consist of spindle cells, multinucleated giant cells, and calcifications embedded in a chondromyxoid matrix. Laboratory findings indicate normal calcium and parathyroid levels, hypophosphatemia, and increased levels of FGF-23 that usually revert to normal after surgical removal. Due to its rarity, the purpose of the study was to report 2 new oral cases of PMT and to review the literature in the head and neck. The first case occurred in the gingiva and had been present for 6 years. The second case was a recurrence of a previously diagnosed PMT in the right mandible that metastasized to the lung and soft tissue. The literature review included 53 cases in the head and neck. There was a predilection for extra-oral sites (76 %) compared to intra-oral sites (24 %) with paranasal sinuses considered the most common location (38 %) followed by the mandible (15 %). There were 9 recurrences that included 3 malignant cases indicating a potentially aggressive tumor. Due to the indeterminate biological behavior of PMT and its rarity, a comprehensive evaluation of medical, laboratory, radiographic, and histological findings are crucial for a definitive diagnosis and treatment.

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“…Mardinger et al-for example-reported the highest prevalence for chondroblastic OS (42%), osteoblastic osteosarcomas being lesser (33%) in JOS [37].…”

Section: Osteosarcoma -Biology Behavior and Mechanismsmentioning

confidence: 99%

Osteosarcoma of the Jaw: Classification, Diagnosis and Treatment

Ferrari¹,

Moneghini²,

Allevi³

et al. 2017

Osteosarcoma - Biology, Behavior and Mechanisms

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Osteosarcomas are rare, highly malignant, bone tumors deined by the presence of malignant mesenchymal cells producing osteoid or immature bone. Osteosarcomas of the jaws are extremely rare, representing about 7% of all osteosarcomas and 1% of all head and neck malignancies. An accurate diagnosis, usually facilitated by chemotherapy (CT), MRI and biopsy, is required in order to deine the stage of the disease and plane the adequate treatment. Aggressive surgical resection and advanced technique reconstruction are the mainstay of treatment, as the single most important factor for cure is radical resection. Clinical outcomes can be improved by a multimodal strategy combining surgery with neo-adjuvant and adjuvant chemotherapy in selected cases, and adjuvant radiotherapy in the absence of clear margins.

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Osteosarcoma of the jaw: an analysis of a series of 74 cases

Abstract: Osteosarcoma of the jaw was the most frequent primary malignant tumour of the jaw. Female gender and a predominantly chondroblastic pattern may be associated with a worse prognosis.

Cited by 61 publications

References 25 publications

Characteristics and Prognostic Factors of Osteosarcoma of the Jaws

Characteristics and Prognostic Factors of Osteosarcoma of the Jaws

Phosphaturic Mesenchymal Tumor: 2 New Oral Cases and Review of 53 Cases in the Head and Neck

Osteosarcoma of the Jaw: Classification, Diagnosis and Treatment

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