Osteosarcoma of the head and neck: A review of the johns hopkins experience

Ha, Patrick K.; Eisele, David W.; Frassica, Frank J.; Zahurak, Marianna; McCarthy, Edward F.

doi:10.1097/00005537-199906000-00023

Cited by 121 publications

(110 citation statements)

References 25 publications

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“…This is considerably lower than the 5-year survival percentage reported for primary osteosarcomas of the head and neck, which range from 50% to 72%. 25,[30][31][32][33] This probably results from the finding that most radiation-induced osteosarcomas are of higher grade and may behave differently biologically.…”

Section: Discussionmentioning

confidence: 99%

Radiation‐induced osteosarcomas of the calvarium and skull base

Patel

Rao

Fox

et al. 2010

Cancer

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BACKGROUND: Although a rare complication of ionizing radiation, radiation-induced osteosarcoma is now more frequently recognized as radiation therapy has become common and cancer survival has increased. To date, publications on radiation-induced osteosarcoma of the cranium are limited to a few small series and case reports. METHODS: Data from 175 patients with a history of sarcoma of the head at The University of Texas M. D. Anderson Cancer Center from 1975 to 2007 were reviewed to identify patients with radiation-induced osteosarcoma. The diagnostic criteria were: 1) osteosarcoma arose within the previously irradiated field; 2) new sarcoma was histologically distinct from the original neoplasm; 3) no evidence of new sarcoma at the time of radiation; and 4) distinct latency period could be recognized. Frequencies and descriptive statistics were obtained for the various characteristics under study. RESULTS: The authors identified 16 patients with radiation-induced osteosarcoma of the cranium at their institution. The average age at diagnosis was 35 years. The median latency period was 12.5 years. Nine patients had skull base tumors, and 7 had calvarial tumors. Of the 14 patients treated surgically, 86% developed local recurrence. The median survival time was 29 months, and the 5-year survival rate was 29.6%. CONCLUSIONS: The authors report the largest series of cranial radiation-induced osteosarcoma. Although radiation-induced osteosarcoma is an uncommon but dire complication of radiotherapy, its incidence will probably increase in the future as the frequency of radiation treatment and cancer survival increase. These tumors are locally aggressive, and despite aggressive surgical and medical management, they have a high rate of local recurrence and mortality. Cancer 2011;117:2120-6.

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Section: Discussionmentioning

confidence: 99%

Radiation‐induced osteosarcomas of the calvarium and skull base

Patel

Rao

Fox

et al. 2010

Cancer

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“…[1][2][3][4][5][6][7][8][9][10] The occurrence of osteosarcoma in the craniofacial bones peaks in the third decade, whereas that in the skeleton peaks in the second decade. 3,4,8,10) The etiology of osteosarcoma is unknown, but the major risk factors for development of osteosarcoma in craniofacial bones may be similar to those of the long skeletal bones, consisting of exposure to radiation, retinoblastoma, Li-Fraumeni syndrome, and Paget's disease. 3,4,9,10) The skull is a favored site for osteosarcoma arising out of Paget's disease.…”

Section: Discussionmentioning

confidence: 99%

“…10) Osteosarcoma tends to occur in the long bones of the extremities, whereas only 5% to 6% arise in the craniofacial bones. 3,4,8,10) The vast majority of craniofacial osteosarcomas are located in the zygomatic bone, whereas tumors affecting the skull are rare. 2) We report a case of osteosarcoma of the parietooccipital bone and describe the radiological features, clinical symptoms, and surgical treatment.…”

Section: Introductionmentioning

confidence: 99%

Osteosarcoma Arising From the Skull. Case Report.

Kanazawa

Yoshida

Takahashi

et al. 2003

Neurol. Med. Chir.(Tokyo)

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A 20-year-old male presented with an osteosarcoma in the right parieto-occipital bone occurring as a painless occipital lump which had rapidly enlarged in the 6 months prior to admission. The neuroimaging appearance resembled intraosseous meningioma. Gross total resection of the tumor was achieved. The final histological diagnosis was osteosarcoma. Osteosarcomas of craniofacial region have a better prognosis than those of the skeletal bones, and distant metastasis is rare. Local recurrence is the most significant factor contributing to poor outcome. Complete excision with negative margins is the key to a better outcome. Adjuvant therapy may be an option in cases of incomplete excision. Advances in target chemotherapy may diminish the significant morbidity associated with these lesions.

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“…2,4,5 Most common sites of involvement include the mandible and less commonly the maxilla and sphenoid sinus. The present case is unique in that this pregnant 18-year-old patient presented with only progressive vision loss and was found to have a primary osteosarcoma of the skull base with compression of the left optic nerve.…”

Section: Discussionmentioning

confidence: 99%

“…Given the size and location of the lesion, it is likely that the vision loss in the left eye occurred gradually over an extended period of time, but was simply noted acutely by the patient six days prior to admission. Complete surgical resection is the primary method of treatment of the primary tumour, [1][2][3]5 however the anatomy of the head and neck often makes complete resection difficult. 6 Adjuvant chemotherapy typically consists of cisplatin, doxorubicin, and high-dose methotrexate.…”

Section: Discussionmentioning

confidence: 99%

Primary Osteosarcoma of the Skull Base in a Pregnant Patient

Malalis¹,

Lee²,

Jay³

2013

Neuro-Ophthalmology

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An 18-year-old female who was 14 weeks pregnant first noted vision loss in her left eye six days prior to admission. Ophthalmologic examination revealed 20/20 vision in the right eye and count fingers vision in the left eye. A marked relative afferent pupillary defect was present in the left eye. Ophthalmoscopic examination revealed a trace optic nerve pallor temporally in the left eye without associated disc oedema or haemorrhage. Magnetic resonance imaging of the brain demonstrated a heterogeneous mass of the left sphenoid sinus extending superiorly causing compression of the intracranial portion of the left optic nerve, and laterally into the left cavernous sinus. The patient underwent transphenoidal resection of the tumour whose histologic morphology revealed a grade 2 osteosarcoma. Following resection, vision returned to 20/20 in the left eye. The patient has been treated with chemotherapy with close monitoring of her pregnancy.

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Osteosarcoma of the head and neck: A review of the johns hopkins experience

Cited by 121 publications

References 25 publications

Radiation‐induced osteosarcomas of the calvarium and skull base

Radiation‐induced osteosarcomas of the calvarium and skull base

Osteosarcoma Arising From the Skull. Case Report.

Primary Osteosarcoma of the Skull Base in a Pregnant Patient

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