Osteosarcoma of the anterior maxilla mimicking a periapical pathology: A case report

Pires, Mariana Domingos; Martins, Jorge N.R.; Dias, Gonçalo; Doutel, Delfim; Ordinola‐Zapata, Ronald

doi:10.1111/aej.12491

Cited by 1 publication

(6 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Osteosarcomas in the head and neck region are rare, difficult to diagnose, and may present with varying signs and symptoms [6]. Osteosarcomas are difficult to diagnose because of false biopsy results which range from 17% to 25% [3,4].…”

Section: Discussionmentioning

confidence: 99%

“…The most common complaint is painless swelling, which can sometimes be associated with dysesthesia and/or limited mouth opening [1]. These lesions in the maxilla may mimic a periapical lesion of endodontic (dental) origin, and the differential diagnosis is mandatory [6].…”

Section: Discussionmentioning

confidence: 99%

“…Many papers refer to low numbers of treated patients and/ or described case reports only [5]. Early diagnosis and treatment are essential to improve long-term prognosis [6].…”

Section: Introductionmentioning

confidence: 99%

“…Diagnosing osteosarcoma is very challenging and osteosarcoma is often misdiagnosed as osteomyelitis due to the nonspecificity of its symptoms upon initial presentation [6,23,24].…”

mentioning

confidence: 99%

“…Portuguese authors have reported that surgical resection of a lesion with clear margins followed by chemotherapy is associated with the best prognosis for osteosarcoma of the jaw [6].…”

mentioning

confidence: 99%

See 4 more Smart Citations

Highly Aggressive Osteosarcoma of the Ethmoids and Maxillary Sinus-A Case of Successful Surgery and Proton Beam Radiotherapy in a 65-Year-Old Man

et al. 2022

View full text Add to dashboard Cite

Sarcomas in the head and neck area are rare diseases with an incidence of under 1% of all head and neck malignant tumours. Osteosarcomas or osteogenic sarcomas consist of neoplastic cells that produce osteoid bone or immature bone. Sarcomas develop more in the mandible than the maxilla. The exact diagnosis of different types of sarcomas is based on the immunohistochemical investigation. These rare tumours are of mesenchymal origin; osteosarcomas and chondrosarcomas are the most common types—Ewing’s sarcomas. The use of proton beam radiotherapy in the treatment of osteosarcoma of the maxilla is rarely reported in the literature. We present a case of successfully treated (surgery and proton beam radiotherapy) poorly differentiated highly aggressive osteosarcoma in the ethmoids and maxillary sinus and morbidity after the treatment. We were presented with a case of a 65-year-old man with anaesthesia and palsy of the right face. The stomatology department performed the extraction of a tooth. One month later, the wound was still open. The histology showed an osteogenic sarcoma in the area of the wound. The oncologist and maxillofacial surgeons in a catchment hospital recommended a nonsurgical approach. Hence, we performed a radical maxillectomy and ethmoidectomy, after which we continued with proton bean radiotherapy. The patient is now five years after therapy without signs of sarcoma; however, he has blindness in the right eye and reduced vision in the left eye, as well as gliosis of the brain, vertigo, tinnitus, trismus, and ancylostomiases. Head and neck osteosarcomas treatment is considered a complex multidisciplinary task. It is currently argued that there is no clear therapeutic protocol for successful treatment. Innovations in treatment modalities such as proton beam radiotherapy appear to have potential, although their effects on long-term morbidity and survival outcomes are still undetermined. We present a rare case report of an osteosarcoma of the maxilla involving an innovative, successful treatment procedure combining surgical excision followed by proton beam radiotherapy. This treatment approach may enable maximum tumour control. This protocol has not been adequately described in the world literature for this diagnosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Many papers refer to low numbers of treated patients and/ or described case reports only [5]. Early diagnosis and treatment are essential to improve long-term prognosis [6].…”

Section: Introductionmentioning

confidence: 99%

“…Diagnosing osteosarcoma is very challenging and osteosarcoma is often misdiagnosed as osteomyelitis due to the nonspecificity of its symptoms upon initial presentation [6,23,24].…”

mentioning

confidence: 99%

“…Portuguese authors have reported that surgical resection of a lesion with clear margins followed by chemotherapy is associated with the best prognosis for osteosarcoma of the jaw [6].…”

mentioning

confidence: 99%

See 3 more Smart Citations