Osteoradionecrosis of the hyoid bone: A report of 3 cases

Monceaux, Guy; Périé, Sophie; Montravers, F.; Angelard, B.; Corlieu, P; Guily, Jean Lacau St

doi:10.1016/s0196-0709(99)90081-9

Cited by 16 publications

(14 citation statements)

References 9 publications

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“…While ORN of the mandible is commonly discussed in the context of head and neck radiation, its occurrence in the hyoid bone is rarely reported and likely underappreciated. A review of the literature reveals only 20 previously reported cases 2–6…”

Section: Discussionmentioning

confidence: 99%

Mortality, morbidity, and cost associated with febrile neutropenia in adult cancer patients

Kuderer

Dale

Crawford

et al. 2006

Cancer

1,046

776

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BACKGROUNDHospitalization for febrile neutropenia (FN) in cancer patients is associated with considerable morbidity, mortality, and cost. The study was undertaken to better define mortality, length of stay (LOS), cost, and risk factors associated with mortality and prolonged hospitalization in cancer patients with FN.METHODSThe longitudinal discharge database derived from 115 US medical centers was used to study all adult cancer patients hospitalized with FN between 1995 and 2000, comprising a total of 41,779 patients. Primary outcomes included mortality, LOS, and cost per episode.RESULTSOverall, in‐hospital mortality was 9.5%. Patients without any major comorbidities had a 2.6% risk of mortality, whereas 1 major comorbidity was associated with a 10.3% and more than 1 major comorbidity with a ≥21.4% risk of mortality, respectively. Mean (median) length of stay was 11.5 (6) days, and the mean (median) cost was $19,110 ($8,376) per episode of FN. Patients hospitalized for ≥10 days (35% of all patients) accounted for 78% of overall cost. Independent major risk factors for inpatient mortality included invasive fungal infections, Gram‐negative sepsis, pneumonia and other lung disease, cerebrovascular, renal, and liver disease. Main predictors for LOS ≥10 days included leukemia, invasive fungal infections, other types of infection, and several comorbid conditions.CONCLUSIONFactors associated with increased mortality, LOS, and cost in hospitalized adult cancer patients with FN include patient characteristics, type of malignancy, comorbidities, and infectious complications. These factors may be useful in identifying patients at increased risk of serious medical complications and mortality for more aggressive supportive care measures. Cancer 2006. © 2006 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

Mortality, morbidity, and cost associated with febrile neutropenia in adult cancer patients

Kuderer

Dale

Crawford

et al. 2006

Cancer

1,046

776

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“…7 Hyoid ORN is a little known entity that has only been described in a total of 7 patients whom we could identify in the clinical literature. [5][6][7][8] In the reported cases, the most frequent associated symptom was odynophagia, 6 which was also seen in our group. However, radiation therapy often causes mucositis in the first several months following completion.…”

Section: Discussionmentioning

confidence: 99%

“…According to the article by Monceaux et al, 7 smoking and alcohol use are thought to play roles in the development of ORN. All the patients in our case series reported significant smoking histories.…”

Section: Discussionmentioning

confidence: 99%

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Osteoradionecrosis of the Hyoid Bone: Imaging Findings

Yoo

Rosenthal

Mitchell

et al. 2009

AJNR Am J Neuroradiol

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“…Osteoradionecrosis is unlikely to occur if the radiation dose is below 60 Gy, delivered by standard fractions [14], but has a higher likelihood of occurrence if the dose is higher than 65–75 Gy [13]. Other risk factors for the development of osteoradionecrosis include periodontitis, poor oral hygiene, alcohol and tobacco use [15], dental extractions, tumor size, location and stage, proximity of tumor to bone, and preirradiation bone surgery [13]. Reuther et al [16] studied 830 head and neck tumor patients evaluated during a 30-year period and suggested that tumor stage, infiltration of adjacent bone, and tooth extractions are the most important predisposing factors for osteoradionecrosis.…”

Section: Osteoradionecrosismentioning

confidence: 99%

Imaging of the Head and Neck following Radiation Treatment

Debnam

2011

Pathology Research International

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Squamous cell carcinoma of the head and neck occurs in approximately 40,000 patients annually in the United States and is often treated with radiation therapy. Radiological studies are obtained following treatment for head and neck malignancies to assess for recurrent tumor, posttreatment changes, and associated complications. Radiation treatment creates a difficult clinical picture for oncologists, head and neck surgeons, neuroradiologists, and neuropathologists. As post-treatment imaging studies are often discussed at radiology/pathology working conferences, knowledge of the imaging appearance of radiation-associated changes in the head and neck and the terminology used by neuroradiologists may not only aid in interpretation of the pathologic specimen, but also assist in communications with neuroradiologists and referring clinicians.

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Osteoradionecrosis of the hyoid bone: A report of 3 cases

Cited by 16 publications

References 9 publications

Mortality, morbidity, and cost associated with febrile neutropenia in adult cancer patients

Mortality, morbidity, and cost associated with febrile neutropenia in adult cancer patients

Osteoradionecrosis of the Hyoid Bone: Imaging Findings

Imaging of the Head and Neck following Radiation Treatment

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