Osteoradionecrosis of mandible: Case report with review of literature

Ravindran, Rathy; S, Sunil Kumar

doi:10.4103/0976-237x.114882

Cited by 18 publications

(21 citation statements)

References 8 publications

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“…Also mandible is more likely in the field of radiation for oropharyngeal cancers. [1,5] ORN pathophysiology remains controversial with various theories put forward. There is classic triad described by Meyer in the pathophysiology of ORN includes Radiation, trauma and infections.…”

Section: Discussionmentioning

confidence: 99%

“…ORN is rare after radiation of less than 60Gy. With the older radiation techniques, the rate of ORN was reported to be between 5% and 15%, [1] while with newer techniques such as IMRT, brachytherapy, 3D conformal RT, stereotactic RT, radiofrequency ablation, radioimmunotherapy have decreased rate to 6% or less.…”

Section: Introductionmentioning

confidence: 99%

“…Ewing in 1926 first recognized and reported the bone changes associated with radiotherapy (RT) and described this disease state as radiation osteitis. [1] Since several theories have been propounded to explain its cause but the most widely accepted theory is of hypoxia, hypovascularity, and hypocellularity. [2] ORN ranges from small asymptomatic bone exposures that remain stable for months and heals with conservative management, to severe necrosis with pathologic fracture necessitating surgical intervention and reconstruction.…”

Section: Introductionmentioning

confidence: 99%

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Bilateral Osteoradionecrosis of Mandible: A Case Report

Mantri¹,

Munde²,

Shoeb³

et al. 2014

IJIRSET

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Osteoradionecrosis (ORN) defines exposed irradiated bone, which fails to heal over a period of 3-6 months without evidence of residual or recurrent tumor. It is a long term and serious complication of therapeutic radiotherapy for head and neck cancer. The pathogenesis of ORN has been proposed relating it to a fibroatrophic mechanism including free radical formation, endothelial dysfunction, inflammation, microvascular thrombosis leading to bone and tissue necrosis. Risk factors mainly include radiation related risk factors, surgery, tobacco and alcohol abuse. Removing of diseased teeth after radiotherapy is generally considered the main risk factor in ORN. Prevention of ORN is based on the preventive extractions of decayed or periodontally compromised teeth before radiotherapy. Based on the clinical staging various therapeutic protocols have been suggested. We here report a case of Bilateral mandibular ORN with discussion of clinical features, pathogenesis, preventive measures, and management of ORN.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bilateral Osteoradionecrosis of Mandible: A Case Report

Mantri¹,

Munde²,

Shoeb³

et al. 2014

IJIRSET

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“…1, 2 The occurrence starts after radiation therapy. The tissues undergo hypoxia caused by damaging the capillary blood vessels in normal tissues and then generally ruin the vascularization in the tissues.…”

Section: -3mentioning

confidence: 99%

CBCT analysis in osteoradionecrosis case followed by hyperbaric oxygen treatment (a case study)

Epsilawati

2016

J Dentomaxillofac Sci

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Osteoradinecrosis is an infectious disease and inflammation that occurs in the jaw after doing radio therapy. Radiographic picture of the disease is visible lesions lucent extensive radio in the jaw. In Clinical condition, seen fistula and abscess in the jaw. One therapy for the treatment of this condition is the Hyperbaric Oxygen. The purpose of this paper is to look casereport work hyperbaric oxygen therapy in treating osteoradionecrosis. Patient age55-year-old, woman, came with complaints of pain in left and right lower jaw, since one month ago, after doing radiotherapy for 6 months. Patients diagnosed osteoradionecrosis. for the healing, selected medical therapy and patients are advised for doing oxygen hyperbaric therapy in AL Minto Harjo hospital Jakarta. One month after doing hyperbaric oxygen therapies seen change and healing. Lesions that form still has the same broad but disappeared fistula, abscess dries, necrotic tissue disappeared / reduced as well as the formation of new bone matrix. As conclusion, , obviously able to heal lesions caused osteomielitys oxygen therapy hyperbaric osteoradionecrosis.

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“…[12] Although numerous theories have been promulgated to elucidate its etiology but the utmost expansively acknowledged theory is of hypoxia, hypovascularity, and hypocellularity. [13] Its management also varies according to the severity which ranges from small asymptomatic exposure of the bone which remains stable for months and repairs with conservative management, to severe necrosis with pathologic fracture demanding surgical intervention and reconstruction. ORN patients have to compromise their quality of life leading to serious clinical symptoms such as chronic spontaneous pain, dysphagia, and facial deformation.…”

Section: Introductionmentioning

confidence: 99%