Osteoprotegerin (OPG) and RANKL expression and distribution in developing human craniomandibular joint

Cardá, Carmen; Silvestrini, G.; Ferraris, M; Peydro, A; Bonucci, E.

doi:10.1016/j.tice.2005.03.002

Cited by 31 publications

(27 citation statements)

References 20 publications

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“…OCC is expressed in the final stages of osteoblast differentiation in the bone maturation and mineralization processes 35 . A previous study 36 reported intense and moderate RANKL staining on osteoblasts and osteoclasts. Positive BSP staining was also previously reported 12 during the first week after ovariectomy and OCC expression was clearly changed by ovariectomy 37 .…”

Section: Discussionmentioning

confidence: 78%

Effects of estrogen deficiency combined with chronic alcohol consumption on rat mandibular condyle

Salgado¹,

Marchini²,

Tera³

et al. 2015

Braz. J. Oral Sci.

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Estrogen deficiency and chronic alcohol consumption may have a synergistic and deleterious effect on bone tissue. Aim: To investigate the effects of estrogen deficiency associated with chronic alcohol consumption on the mandibular condyle in rats. Methods: Fifty-four female rats were first divided equally into two groups: ovariectomized (Ovx) and simulated ovariectomy (Sham). One month after the surgeries, these groups were equally sub-divided according to their dietary treatment: G1: Sham/ad-libitum diet; G2: Sham/alcohol; G3: Sham/isocaloric; G4: Ovx/ad-libitum diet; G5: Ovx/alcohol, G6: Ovx/isocaloric. Eight weeks after starting the diets, all animals were anesthetized and sacrificed. The condyles were analyzed histologically, histomorphometrically, and immunohistochemically using the antibodies for bone sialoprotein (BSP), osteocalcin (OCC) and receptor activator of nuclear factor kappa-B ligand (RANKL). Results: Histological analysis of the mandibular condyles showed that Ovx and Sham groups presented almost the same characteristics. The histomorphometric analysis showed that there was a statistically significant difference only between Ovx/isocaloric and Ovx/ad-libitum groups (p=0.049). No difference was observed in the intensity of BSP, OCC, and RANKL antibody staining between the Ovx/alcohol and the other groups. Conclusions: It may be concluded that there was no histomorphometric, histological, or RANKL, BSP, and OCC staining differences between the Ovx/alcohol group and other experimental groups.

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Section: Discussionmentioning

confidence: 78%

Effects of estrogen deficiency combined with chronic alcohol consumption on rat mandibular condyle

Salgado¹,

Marchini²,

Tera³

et al. 2015

Braz. J. Oral Sci.

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“…Therefore, the DNA methylation pattern of RANKL appears to be early established in osteoblast precursors and does not undergo significant changes during the process of differentiation toward osteocytes, which is consistent with reports demonstrating that RANKL is expressed throughout all stages of differentiation of the osteoblastic lineage. 25 To get further evidence for the role of DNA methylation in the expression of RANKL and OPG we studied the effect These results would suggest that mechanisms other than DNA methylation are responsible for the differences in RANKL expression between patients with OA and OP. We can speculate that DNA methylation represents an on/off regulator of RANKL-OPG gene expression, whereas other factors, such as hormones and cytokines in the bone microenvironment, are responsible for the fine tuning of expression in cells with hypomethylated islands.…”

Section: Discussionmentioning

confidence: 99%

Role of DNA methylation in the regulation of the RANKL-OPG system in human bone

et al. 2012

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“…Remodeling is carried out by basic multicellular/bone metabolic units (BMUs). Normally, osteoclasts, which are responsible for resorption, are inhibited by osteoprotegerin (OPG), which is a protein secreted by osteoblasts as inhibitory signal (Carda et al, 2005). The osteoclastic resorption is signaled by the circulating parathyroid hormone and locally secreted receptor activator nuclear kappa-b ligand (RANKL), which binds to RANK receptors on the membrane of osteoclasts (Marx, 2007).…”

Section: Bone Remodeling (Cell Interactions)mentioning

confidence: 99%

Load Transfer Along the Bone-Implant Interface and Its Effects on Bone Maintenance

Faegh¹,

Chou²,

Müftü³

2011

Implant Dentistry - A Rapidly Evolving Practice

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Osteoprotegerin (OPG) and RANKL expression and distribution in developing human craniomandibular joint

Cited by 31 publications

References 20 publications

Effects of estrogen deficiency combined with chronic alcohol consumption on rat mandibular condyle

Effects of estrogen deficiency combined with chronic alcohol consumption on rat mandibular condyle

Role of DNA methylation in the regulation of the RANKL-OPG system in human bone

Load Transfer Along the Bone-Implant Interface and Its Effects on Bone Maintenance

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