Osteoprotegerin in diabetic osteopathy

Valentini, Alessia; Cianfarani, Maria Assunta; Federici, Massimo; Tarantino, Umberto; Bertoli, A

doi:10.1016/j.numecd.2019.08.018

Cited by 10 publications

(13 citation statements)

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“…Our results of the OPG evaluation are in accordance with several studies that analyzed the level of OPG in blood/saliva or crevicular fluid. Valentini et al showed that diabetics have higher plasma OPG concentrations and a lower RANKL/OPG ratio compared to non-diabetics, with OPG levels directly correlating with HbA1c levels [ 17 ]. In order to have a more complete image of the bone remodeling dynamics, OPG/RANKL ratio was also analyzed, and we observed that the initial value was significantly higher in DM group compared to C; post-extraction, the value was reduced for both groups, especially in the systemically affected group.…”

Section: Discussionmentioning

confidence: 99%

Correlations between Salivary Immuno-Biochemical Markers and HbA1c in Type 2 Diabetes Subjects before and after Dental Extraction

et al. 2021

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Dental extraction can trigger certain sequences of complex processes that involve both hard (alveolar bone) and soft tissue (periodontal ligament, gingiva) remodeling. Type 2 diabetes is a serious risk factor for many oral pathologies, both in terms of progression and severity, but also regarding subsequent rehabilitation possibilities. The aim of this study was to establish whether certain molecules: osteoprotegerin (OPG), kappa B nuclear factor receptor activator ligand (RANKL), hepatocyte growth factor (HGF), tumor necrosis factor-α (TNF-α), interleukin 18 (IL-18), matrix metalloproteinase 9 (MMP-9) and oxidative stress markers—total oxidant status (TOS), total antioxidant capacity (TAC)—evaluated in saliva are modified post-extraction in type 2 diabetes mellitus subjects and whether there is a correlation with HbA1c levels. The aforementioned markers plus HbA1c were investigated in a group of systemically healthy subjects (n = 45) and in a type 2 diabetes mellitus group (n = 41) before and three months after a tooth extraction. Diabetes patients’ recorded increased levels of OPG, RANKL, TNF-α, MMP-9, IL-18 and TOS compared to controls both pre- and post-extraction. In both study groups, the average OPG, HGF and TAC level recorded an upward trend three months post-extraction. TNF-α registered a statistically significant decrease only in the diabetes group after dental extraction, together with a decrement of mean HbA1c levels in the diabetes group. By plotting the ROC (receiver operating characteristic) curve, at baseline RANKL, TNF-α, IL-18, MMP-9, TOS and OPG were good predictors of HbA1c levels. Post-extraction, there was a significant correlation between HbA1c and oxidative status biomarkers, however the linear regression model indicated the influence of all studied salivary markers in HbA1c determinism, in a considerable proportion. In conclusion, our study demonstrated that several oxidative status markers and proinflammatory biomarkers are modified in the saliva of diabetic patients and they correlate to HbA1c levels, thus being potential indicators of the post-extraction healing status in the oral cavity.

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Section: Discussionmentioning

confidence: 99%

Correlations between Salivary Immuno-Biochemical Markers and HbA1c in Type 2 Diabetes Subjects before and after Dental Extraction

et al. 2021

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“…For the data in the articles included for analysis, the results are shown in Figure 1 for female patients (24)(25)(26)(27)(28)(29)(30)(31)(32)(33), Figure 2 for male and female patients mixed (34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45), and Figure 3 for male patients (24,(28)(29)(30)32,33,46,47). For the data in Figure 2, females commonly constituted 2/3 of the cases, reflecting that hip fracture prevalence among older women is about double of that among older men.…”

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confidence: 97%

Around the time of a hip fracture, older East Asian female patients tend to measure lower densitometric femoral neck and total hip T-scores than older Caucasian female patients: a literature analysis

Wáng¹

2023

Quant Imaging Med Surg

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The clinical significance of osteoporosis lies in the fractures that occur, and the most important fracture is hip fracture. According to the 1994 World Health Organization (WHO) criteria, the T-score is defined as: (BMD patient -BMD young normal mean )/SD young normal population, where BMD is bone mineral density and SD is the standard deviation. When the femoral neck is measured in adult women, a cutpoint value of patient BMD of 2.5 SD below the BMD young normal mean satisfies that the prevalence of osteoporosis for those aged ≥50 yrs is about 16.2%, the same as the lifetime risk of hip fragility fracture (FF) (1,2). If other sites are also considered, this cutpoint value identifies approximately 30% of postmenopausal women as having osteoporosis, which is approximately equivalent to the lifetime risk of FF at the spine, hip, or forearm. The FF prevalence of older Chinese women is slightly less than half that of Caucasians (3,4). This is the case for hip FF (5-7), radiographic vertebral FF (8), clinical vertebral FF (9-11), and many other FF sites (3,4,12,13). As compared with Caucasians, Chinese demonstrate an overall stronger skeleton property (14). For example, Walker et al. (15) reported that postmenopausal Chinese women have a higher trabecular plate-to-rod ratio and greater whole bone stiffness, translating into a greater trabecular mechanical competence.Following the 1994 WHO definition, densitometric osteoporosis prevalence among a non-Caucasian population should be in proportion to its relative osteoporotic fracture risk with Caucasian data as reference (16). To achieve this goal, various region/ethnic-specific reference BMD databases have been published (3). Furthermore, the cutpoint T-score for defining densitometric osteoporosis should be adjusted according to the osteoporotic fracture risk profile. Based on statistical modeling (3), we proposed that the femoral neck cutpoint T-score is revised from ≤−2.5 to ≤−2.75 for Hong Kong older women when a local BMD reference published by Lynn et al. ( 17) is applied. The same principle can also be applied to Japanese older women if a local BMD reference published by Iki et al. is used (3,18). In an empirical study on women with radiographic vertebral FF as a surrogate clinical endpoint, we recently demonstrated that, at the mean age of around 74, a femoral neck T-score of −2.60 for Italian Caucasians is equivalent to Letter to the Editor

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“…Furthermore, Starup-Linde et al observed a negative correlation between OC levels and HbA1c suggesting that reduced bone turnover may be a consequence of a chronic hyperglycemic state ( Starup-Linde et al, 2014 ). Some recent studies have also shown that patients with diabetes have lower levels of serum OC compared to non-diabetic subjects ( Starup-Linde et al, 2014 ; Valentini et al, 2020 ). Other studies also highlighted the protective effect of osteocalcin on the development of metabolic syndrome and the reduction of cardiovascular risk ( Magni et al, 2016 ).…”

Section: Discussionmentioning

confidence: 98%

“…In contrast to these studies, Asley et al showed that s-RANKL levels did not differ between obese and non-obese individuals ( Ashley et al, 2011 ). However, other research in diabetic patients highlighted significantly higher OPG levels than in non-diabetic subjects and its positive correlation with HbA1c levels ( Valentini et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Identification of bone metabolism disorders in patients with Alström and Bardet-Biedl syndromes based on markers of bone turnover and mandibular atrophy

Jeziorny¹,

Zmysłowska-Polakowska²,

Wyka³

et al. 2022

Bone Reports

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Osteoprotegerin in diabetic osteopathy

Cited by 10 publications

References 50 publications

Correlations between Salivary Immuno-Biochemical Markers and HbA1c in Type 2 Diabetes Subjects before and after Dental Extraction

Correlations between Salivary Immuno-Biochemical Markers and HbA1c in Type 2 Diabetes Subjects before and after Dental Extraction

Around the time of a hip fracture, older East Asian female patients tend to measure lower densitometric femoral neck and total hip T-scores than older Caucasian female patients: a literature analysis

Identification of bone metabolism disorders in patients with Alström and Bardet-Biedl syndromes based on markers of bone turnover and mandibular atrophy

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