Osteoprotegerin and 25-hydroxy vitamin D levels  in patients with diabetic foot

Çağlar, Sever; Çağlar, Aysel; Pilten, Saadet; Albay, Cem; Beytemür, Ozan; Sari, Hakan

doi:10.5606/ehc.2018.60797

Cited by 13 publications

(10 citation statements)

References 27 publications

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“…[25][26][27] Most studies performed so far reported high prevalence of vitamin D deficiency and insufficiency in patients with DFU. [28][29][30][31][32][33][34][35][36][37][38] However, data regarding serum vitamin D levels in patients with DFU living in Mediterranean countries, where there is plenty of sunshine throughout most of the year, are scarce.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Vitamin D Levels in Patients With Diabetic Foot Ulcers

Tsitsou

Dimosthenopoulos

Eleftheriadou

et al. 2021

The International Journal of Lower Extremity Wounds

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Low vitamin D levels have been associated with several diseases as its receptors are expressed in almost all tissues of the human body. Literature data have shown delayed diabetic foot ulcer (DFU) healing in patients with low vitamin D; however, data on the association between vitamin D levels and DFU in Mediterranean countries are scarce. In this cross-sectional study we examined for differences in serum vitamin D levels between patients with DFU, people with diabetes mellitus (DM) without DFU and healthy individuals in a Southern European country. A total of 96 subjects (33 patients with DFU, 35 patients without DFU and 28 healthy controls) were recruited. Medical and dietary history was obtained and total serum 25-hydroxyvitamin D [25(OH)D] levels were determined. Serum vitamin D levels differed significantly among the three groups of participants; sub-analysis showed that healthy individuals had higher vitamin D levels when compared with patients with and without DFU, while vitamin D levels did not differ between patients with and without DFU (17.9 ± 6.7 vs. 19.8 ± 8.7 ng/mL, P = 0.329, respectively). More than half of patients with DM with or without DFU had vitamin D levels <20 ng/ml. A positive correlation was found between vitamin D and sun exposure duration in participants without DFU. In conclusion, although serum vitamin D levels did not differ between people with and without DFU, the prevalence of deficiency and insufficiency was high in both groups in a Mediterranean country. This finding highlights the need for screening and supplementation with vitamin D in individuals with DM.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Vitamin D Levels in Patients With Diabetic Foot Ulcers

Tsitsou

Dimosthenopoulos

Eleftheriadou

et al. 2021

The International Journal of Lower Extremity Wounds

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“…A total of 12 studies reported between 2013 and 2022 satisfied the inclusion criteria for the meta‐analysis among the 573 distinctive reports 12‐23 . This meta‐analysis study included 7586 subjects with diabetes mellitus at the beginning of the study; 1565 were using diabetic subjects with foot ulcer wounds, and 6021 were non‐ulcerated diabetic subjects.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 12 studies reported between 2013 and 2022 satisfied the inclusion criteria for the meta‐analysis among the 573 distinctive reports. 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 This meta‐analysis study included 7586 subjects with diabetes mellitus at the beginning of the study; 1565 were using diabetic subjects with foot ulcer wounds, and 6021 were non‐ulcerated diabetic subjects. All studies evaluated the association between vitamin D deficiency and diabetic foot ulcer wounds in diabetic subjects.…”

Section: Resultsmentioning

confidence: 99%

“…This meta‐analysis comprised 7586 subjects with diabetes mellitus at the beginning of the study; 1565 were using diabetic subjects with foot ulcer wounds, and 6021 were non‐ulcerated diabetic subjects. 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 Diabetic subjects with foot ulcer wounds had significantly lower vitamin D levels, higher prevalence of vitamin D deficiency, and higher severe vitamin D deficiency compared with non‐ulcerated diabetic subjects. Yet, the analysis of results must be done with attention due to the low number of selected studies for the meta‐analysis and the low sample size of 4 out of 12 selected studies found for the meta‐analysis with ≤100 subjects as sample size; recommending the necessity for additional studies with a larger sample size to confirm these findings or perhaps to significantly impact confidence in the effect assessment.…”

Section: Discussionmentioning

confidence: 98%

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Association between vitamin D deficiency and diabetic foot ulcer wound in diabetic subjects: A meta‐analysis

Lin

Yang

et al. 2022

International Wound Journal

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A meta‐analysis was performed to evaluate the association between vitamin D deficiency and diabetic foot ulcer wounds in diabetic subjects. A systematic literature search up to March 2022 incorporated 7586 subjects with diabetes mellitus at the beginning of the study; 1565 were using diabetic subjects with foot ulcer wounds, and 6021 were non‐ulcerated diabetic subjects. Statistical tools like the dichotomous and contentious method were used within a random or fixed‐influence model to establish the odds ratio (OR) and mean difference (MD) with 95% confidence intervals (CIs) to evaluate the influence of vitamin D deficiency in managing diabetic foot ulcer wound. Diabetic subjects with foot ulcer wounds had significantly lower vitamin D levels (MD, −6.48; 95% CI, −10.84 to −2.11, P < .004), higher prevalence of vitamin D deficiency (<50 nmoL/L) (OR, 1.82; 95% CI, 1.32‐2.52, P < .001), and higher prevalence of severe vitamin D deficiency (OR, 2.53; 95% CI, 1.65‐3.89, P < .001) compared with non‐ulcerated diabetic subjects. Diabetic subjects with foot ulcer wounds had significantly lower vitamin D levels, higher prevalence of vitamin D deficiency, and higher prevalence of severe vitamin D deficiency compared with non‐ulcerated diabetic subjects. Further studies are required to validate these findings.

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“…For example, increased levels of OPG in patients receiving dialysis predict the progression of calcified plaques in the aorta; 29,30 and higher OPG levels in patients suffering from diabetes are independently associated with coronary artery calcification and predict near cardiovascular events. 31,32 It should be noted that OPG effects may be different as atherosclerotic lesion progresses. At the beginning of such ongoing detrimental stages, OPG may be increased to compensate for vasculature damage through activating inflammatory pathways.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Serum and Gene Expression Levels of RANK, RANKL and Osteoprotegerin Inflammatory Pathway with Unstable Angina: A Case-control Study

Farrokhian¹,

Miraftab²,

Chenari³

et al. 2021

IJAAI

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Osteoprotegerin (OPG), receptor activator of nuclear factor-kappa B (RANK) and receptor activator of nuclear factor-kappa B ligand (RANKL), the members of the tumor necrosis factor (TNF) family, have multiple effects on bone metabolism, endocrine functions and, as an inflammatory pathway, in the immune system. This study tried to determine the association of the OPG/RANKL/RANK axis with the severity of unstable angina (UA) as an inflammatory condition. Our study involved 50 patients with UA and 50 healthy people. Serum and peripheral blood mononuclear cells were isolated from all participants. Serum levels and gene expression of OPG, RANKL, and RANK in mononuclear cells were measured by enzyme-linked immunosorbent assay (ELISA) and real-time polymerase chain reaction (RT-PCR), respectively. For each patient with UA, the thrombolysis in myocardial infarction (TIMI) and the global registry of acute coronary events (GRACE) scores were determined to evaluate the severity of the disease. Then we analyzed the relation of OPG, RANKL, and RANK levels with TIMI and GRACE scores in patients with UA. Discriminate analysis was used to predict the combinational models of such factors on the prediction of UA. Serum levels of OPG and RANKL (p<0.001) and gene expression of RANKL (p<0.001) were significantly more in patients than those in healthy ones. No relation was seen between the OPG/RANKL/RANK axis and the severity of UA according to TIMI and GRACE scores. Our study shows that serum level, as well as gene expression of OPG/RANKL/RANK axis neither, predicts the occurrence of UA nor shows any relationship with its severity.

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Osteoprotegerin and 25-hydroxy vitamin D levels in patients with diabetic foot

Cited by 13 publications

References 27 publications

Evaluation of Vitamin D Levels in Patients With Diabetic Foot Ulcers

Evaluation of Vitamin D Levels in Patients With Diabetic Foot Ulcers

Association between vitamin D deficiency and diabetic foot ulcer wound in diabetic subjects: A meta‐analysis

The Relationship between Serum and Gene Expression Levels of RANK, RANKL and Osteoprotegerin Inflammatory Pathway with Unstable Angina: A Case-control Study

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