Osteoporotic Fracture Risk in Rheumatoid Arthritis

Syngle, Tanya; Kaur, Sudeep; Garg, Nidhi

doi:10.22159/ijpps.2018v10i3.22751

Cited by 6 publications

(6 citation statements)

References 29 publications

(26 reference statements)

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“…The decrease in BMD causes increase in proximal femoral morphometry, and this may be due to cortical thinning, age-related bone loss, and dietary habit which increases the risk of hip fracture. The variations in FNAL may be related to the higher occurrence of hip fracture [18][19][20]. The present study found negative correlation between FN-BMD and FNAL.…”

Section: Discussionsupporting

confidence: 53%

Morphometric Study of Proximal Femur and Its Correlation With Bone Mineral Density. A Cross-Sectional Study

Nayak

Baisakh

Chinara

2018

Asian J Pharm Clin Res

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Objective: Proximal femoral morphometries such as hip axis length (HAL), femoral neck (FN) axis length (FNAL), and FN shaft angle (FNSA) are important parameters for prediction of fracture risk. These parameters are affected by factors such as body habitus, age, sex, race, bone mineral density (BMD), and body mass index. Hence, the present study was designed to evaluate the relationship between proximal femoral morphometry and BMD. Methods:We conducted an observational cross-sectional study in 168 patients. The measurements of radiological parameters such as HAL, FNAL, and FNSA were taken using dual-energy X-ray absorptiometry scan. FN-BMD was measured using LUNAR XR scanner and expressed as gm/cm². The correlation between proximal femoral morphometry and FN-BMD has been studied using Karl Pearson correlation coefficient (r). Results:The mean age, height, weight, HAL, FNAL, FNSA, and FN-BMD of the study population were found to be 58.72 years, 160.15 cm, 64.38 kg, 104.14 mm, 103.51 mm, 128.51°, and 0.761 g/cm², respectively. FN-BMD had a negative correlation with HAL (r=−0.791), FNAL (r=−0.734), and FNSA (r=−0.713) where p=0.000. Conclusion:There is a significant correlation between FN-BMD and proximal femoral morphometry. This observation will be helpful in exploration of its clinical significance in proximal femoral fracture.

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Section: Discussionsupporting

confidence: 53%

Morphometric Study of Proximal Femur and Its Correlation With Bone Mineral Density. A Cross-Sectional Study

Nayak

Baisakh

Chinara

2018

Asian J Pharm Clin Res

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“…Steroids were first used clinically to treat dermatological diseases due to their anti-inflammatory action. Corticosteroids are commonly indicated in treating various types of inflammatory and immune-mediated disorders such as adrenocortical insufficiency, rheumatic diseases [9], asthma, and skin diseases [10]. In dentistry, they are generally used to relieve pain, anxiety and for the management of oral lesions that are manifestations of systemic disorders [11].…”

Section: Introductionmentioning

confidence: 99%

Corticosteroids - Assets and Liabilities on Periodontium

Harshita

Kamath

Swati

2018

Asian J Pharm Clin Res

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Corticosteroids are chemically similar to endogenous cortisol and are used fundamentally as replacement therapy in patients with adrenal insufficiency, and used as anti-inflammatory agents. They are widely used in systemic diseases such as rheumatoid arthritis, asthma, and connective tissue disorders. In dentistry primarily these are used to decrease post-operative pain and edema in inflammatory diseases such as oral lichen planus, pemphigus, and recurrent aphthous stomatitis. This action is predominantly due to eicosanoid formation that inhibits phospholipase A2 activity. Corticosteroids can be supplemented either topically systemically or as inhalational therapy. Research suggests that local application of corticosteroids shows favorable effect on the periodontal ligament and possesses antiresorptive effect, but long-term systemic therapy is a risk for periodontal diseases which may provoke attachment loss and disruption of transseptal fibers. Oral manifestations are common with the use of inhaled steroids and are dependent on dose, frequency, duration, and inhaler use. It is commonly associated with ulceration of tongue, buccal mucosa, and occasionally on the gingiva due to xerostomia and immune suppression. It also causes a decrease in bone mineral density. This review explains about various effects of different types of corticosteroids on periodontium used in dentistry.

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“…Corticosteroids are commonly advised as replacement therapy in treating various types of inflammatory and immunosuppressive disorders. 4,5 Steroidal drugs are known to exert definite antiallergic, anti-inflammatory and immunosuppressive effects. 1 However, despite these beneficial actions, corticosteroids are also known to cause adverse reactions likerashes, clouding of the lens, weakness in the muscles, GIT disorders and candidiasis.…”

Section: Introductionmentioning

confidence: 99%

Effect of Long-term Use of Steroidal Anti-inflammatory Drugs on the Periodontal State: A Review

2020

IJFMT

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Corticosteroids are chemically similar to endogenous cortisol and mostly prescribed for their antiinflammatory and immunosuppressive properties, which are due to the inhibition of phospholipase A2 activity. These drugs are extensively used in the treatment of a plethora of autoimmune disorders such as rheumatoid arthritis, various breathing disorders and also disorders of connective tissue. In the field of dentistry these drugs are prescribed in most of the mucocutaneous disorders such as they are mostly used in inflammatory diseases such as oral lichen planus, pemphigus, and oral stomatitis to alleviate postoperative discomfort and swelling. These drugs can be administered systemically,topically or asinhalational therapy. Evidence concludes that short term corticosteroids possess antiresorptive properties and its local application shows a favourable effect on the periodontal ligament, but when administered systemically for a long period could lead to periodontal diseases as it has shown to increase attachment with alveolar bone and destruction of transseptalfibers. Oral manifestations are dependent on duration,dose and frequency of use. It is commonly associated withmoniliasis, dental caries,altered taste sensation, ulceration of the tongue, buccal mucosa, and gingiva due to xerostomia,gingival inflammation, periodontal inflammation,and immune suppression. They can either cause dramatic improvement or dramatic adverse reactions which can lead to a considerable increase in the distributionof periodontal disorders. In patients on long-term corticosteroid therapy, oral health is generally not given importance during management. Hence this review explains about various effects of different types of corticosteroids on periodontium used in dentistry.

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Osteoporotic Fracture Risk in Rheumatoid Arthritis

Cited by 6 publications

References 29 publications

Morphometric Study of Proximal Femur and Its Correlation With Bone Mineral Density. A Cross-Sectional Study

Morphometric Study of Proximal Femur and Its Correlation With Bone Mineral Density. A Cross-Sectional Study

Corticosteroids - Assets and Liabilities on Periodontium

Effect of Long-term Use of Steroidal Anti-inflammatory Drugs on the Periodontal State: A Review

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