Osteoporosis risk in Type 2 diabetes patients

Rubin, Mishaela R.; Schwartz, Ann V.; Kanis, John А.; Leslie, William D.

doi:10.1586/17446651.2013.835567

Cited by 5 publications

(8 citation statements)

References 26 publications

(18 reference statements)

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“…Two systematic reviews establish an increased risk of fractures in patients with DM (24,25). Although there are common risk factors that potentiate osteoporosis in patients with DM, MS and COPD, DM is an independent risk factor (26). However number of fractures in our study does not significantly differ regarding the presence of DM (p=0.401) or prediabetes (p=0.673).…”

Section: Comorbidity Resultscontrasting

confidence: 55%

“…Body weight and height were measured and the body mass index (BMI) was calculated by dividing weight by height squared (kg/m 2 ). According to BMI all patients were classified as underweight (<18,5), normal (18,5 -24,99), overweight (25)(26)(27)(28)(29)99) and obese (>30). Waist circumference was measured at the approximate midpoint between the lower margin of the last palpable rib and the top of the iliac crest according to the WHO STEPS protocol (50).…”

Section: Anthropometric Indicesmentioning

confidence: 99%

“…Available studies suggest that DM may have impact on quality of life (9), lung function (10)(11)(12)(13)(14)(15), natural course of COPD (number of exacerbations) (3,(16)(17)(18)(19)(20)(21) as well as to affect comorbidities (22) in COPD patients. DM is also associated with arterial hypertension, hypovitaminosis D and metabolic syndrome (MS) (23)(24)(25)(26)(27)).…”

Section: Introductionmentioning

confidence: 99%

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Diabetes mellitus type 2 in hospitalized patients with chronic obstructive pulmonary disease

Mekov¹,

Slavova²,

Genova

et al. 2015

Preprint

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Diabetes mellitus (DM) affects 2-37% of patients with chronic obstructive pulmonary disease (COPD), with results being highly variable between studies. DM may also correlate with disease characteristics.The aim of this study was to examine the prevalence of DM and its correlation with comorbidities and COPD characteristics in patients with COPD admitted for exacerbation. 152 patients were studied for presence of DM. All of them were (13/44) of females (p=0.379). The prevalence of DM in this study is significantly higher when compared to an unselected Bulgarian population (12,8% in subjects over 45 years).91% of patients with newly discovered diabetes had glycated hemoglobin (HbA1c)≥6,5% suggesting prolonged hyperglycemia. There is a correlation between the presence of DM and MS (p=0.008). The presence of DM is associated with more severe exacerbations (hospitalizations) during the previous year (p=0.003) and a longer hospital stay (p=0.006).DM is not associated with reduced quality of life and worse pulmonary function. The patients with COPD admitted for exacerbation are at great risk for impaired glucose metabolism which is associated with worse COPD characteristics. The majority of the patients in this study are unaware of having DM.PeerJ PrePrints | https://dx.doi.org/10.7287/peerj.preprints.939v1 | CC-BY 4.0 Open Access |

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Section: Comorbidity Resultscontrasting

confidence: 55%

Section: Anthropometric Indicesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Diabetes mellitus type 2 in hospitalized patients with chronic obstructive pulmonary disease

Mekov¹,

Slavova²,

Genova

et al. 2015

Preprint

View full text Add to dashboard Cite

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“…Although several studies have investigated the association between diabetes and osteoporosis [ 18 – 20 ] and different theories have been proposed [ 8 , 9 , 11 ], the mechanism by which diabetes increases the risk of fractures, independent of BMD, has not been properly identified. The reported increase in fracture risk might be due to factors such as changes in bone geometry and microarchitecture that compromise bone strength and are not reflected in BMD measurements [ 21 , 22 ] or even to several other factors, among which is chronic hyperglycemia.…”

Section: Discussionmentioning

confidence: 99%

“…Several reports suggest that T2DM affects both the trabecular and cortical bones increasing the risk for hip, spine, and radius fractures. Although osteopenia has been recognized in T2DM patients pointing to an early screening and prevention of osteoporosis [ 9 , 10 ], there are many studies that indicate an increase in bone mineral density (BMD) in diabetic postmenopausal women, especially in those with a great body mass index [ 11 , 12 ]. A recent study showed that there is an association between the increased cortical porosity in T2DM postmenopausal women and fragility fractures [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures

Mello-Sampayo

Agripino

Stilwell³

et al. 2017

International Journal of Endocrinology

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There is controversy concerning the diabetes impact on bone quality, notorious in type 2 diabetic postmenopausal women. One pointed cause might be uncontrolled glycemia. In this study, the effect of chronic hyperglycemia in bone turnover, morphology, and biomechanics was evaluated in female Wistar rats in the presence/absence of estrogens (ovariectomy). Animals (n = 28) were divided into sham, ovariectomized (OVX), hyperglycemic (streptozotocin 40 mg/kg, single-dose i.p.-STZ), and hyperglycemic-ovariectomized (STZ + OVX) animals. Blood biomarkers were estimated 60 days postovariectomy. Body weight, vertebral microarchitecture (L4-histomorphometry), femur biomechanical properties (bending tests), tibia ultrastructure (scanning electron microscopy), and femur and urinary calcium (atomic absorption) were also evaluated. The increased PINP/CTX ratio of hyperglycemic animals and the similar ratio between STZ + OVX and healthy animals contrasting with the lower ratio of OVX (in line with its histomorphometric data) suggest a tendency for improved bone formation in hyperglycemic-ovariectomized animals. The increased tibia medullar canal, which contrasts with the unaffected cortical thickness of both hyperglycemic groups while that of OVX decreased, was associated to the increased stiffness and strength of STZ + OVX bones compared to those of OVX, in line with the observed ultrastructure. Concluding, chronic hyperglycemia in ovariectomized female rats causes bone morphological changes that translate positively in the ultrastructure and mechanical properties of cortical bones.

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A Mendelian Randomization Study of the Effect of Type-2 Diabetes and Glycemic Traits on Bone Mineral Density

Ahmad

Leong

Miller

et al. 2016

Journal of Bone and Mineral Research

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Type-2 diabetes (T2D) is associated in observational studies with both higher bone mineral density (BMD) and higher fracture risk for given BMD. These relationships may however be confounded by factors such as body mass index (BMI). Here we used Mendelian randomization (MR) to obtain non-confounded estimates of the effect of T2D and glycemic traits on BMD. We identified genetic variants strongly associated with T2D risk (34,840 T2D cases and 114,981 controls) and fasting glucose (133,010 nondiabetic individuals), but not associated with BMI, and determined the effects of these variants on BMD (up to 83,894 individuals). Using these variants as instrumental variables, we found that a genetically-increased risk of T2D increased femoral neck BMD (+0.034 SD in BMD per unit increase in log-odds of T2D [95% CI, 0.001 to 0.067; p = 0.044]). Genetically-increased fasting glucose also increased femoral neck BMD (+0.13 SD in BMD per mmol/L increase in fasting glucose [95% CI, 0.01 to 0.25; p = 0.034]). Similar nonsignificant trends were observed for the effects of T2D and fasting glucose on lumbar spine BMD. Our results indicate that both genetically-increased T2D risk and genetically-increased fasting glucose have weak positive effects on BMD. © 2016 American Society for Bone and Mineral Research.

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Osteoporosis risk in Type 2 diabetes patients

Cited by 5 publications

References 26 publications

Diabetes mellitus type 2 in hospitalized patients with chronic obstructive pulmonary disease

Diabetes mellitus type 2 in hospitalized patients with chronic obstructive pulmonary disease

Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures

A Mendelian Randomization Study of the Effect of Type-2 Diabetes and Glycemic Traits on Bone Mineral Density

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