Osteoporosis: overlooked in men for too long

Endocrinology, The Lancet Diabetes &

doi:10.1016/s2213-8587(20)30408-3

Cited by 23 publications

(9 citation statements)

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“…Clinically, osteoporosis in men have been overlooked for too long [ 29 ]. More attention has been paid to the prevention and treatment of osteoporosis in postmenopausal women, while ignoring the disease in men [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Differences in the global exposure, mortality and disability of low bone mineral density between men and women: the underestimated burden in men

Zhu

Guo

et al. 2023

BMC Public Health

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Talking about osteoporosis, we tend to focus on post-menopause women who are at increased risk due to estrogen depletion, while less attention has been paid to the disease in men. Currently, there is a lack of understanding about the difference of osteoporosis incidence and burden by sex. In this study, we used data from the Global Burden of Disease Study 2019 (GBD 2019) to compare the difference in the prevalence and burden of low bone mineral density (LBMD) between men and women, by location, year, age and socio-demographic index. We found the prevalence of LBMD was higher in women than in men. However, the age standardized mortality rate was greatly higher in men than in women. Using disability-adjusted life year (DALY) to measure the burden, we also observed higher age standardized DALY rate in men. Using sociodemographic index (SDI) as the measure of social development level, we found that higher mortality and DALY rates were mainly seen in middle and high SDI countries. Falls were the leading cause for of deaths and disabilities in both men and women with LBMD, followed by transport injuries. Fall-related mortality was higher in women, while transport injuries caused more deaths and disabilities in men. Conclusively, more attention should be paid to osteoporosis in men, and related policies, clinical practices, and guidelines are in need to reduce the burden of LBMD and osteoporosis in men.

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Section: Discussionmentioning

confidence: 99%

Differences in the global exposure, mortality and disability of low bone mineral density between men and women: the underestimated burden in men

Zhu

Guo

et al. 2023

BMC Public Health

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“…There is a common misconception that LBMD and osteoporosis affects only post-menopause women. Indeed, osteoporosis in men has been overlooked for too long ( 5 ). Underdiagnosis and undertreatment of osteoporosis may underline the lower prevalence but higher mortality and disability rate in men for the past decades.…”

Section: Discussionmentioning

confidence: 99%

“…It is estimated that approximately half of women suffer at least one bone fracture after menopause ( 4 ). Osteoporosis causes about 8.9 million fractures globally and 20–25% occur in men every year ( 5 ). In France, over 170 thousand patients were admitted to hospital due to osteoporotic fractures in 2013 ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

Global, Regional, and National Burden of Low Bone Mineral Density From 1990 to 2019: Results From the Global Burden of Disease Study 2019

et al. 2022

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ObjectiveWe aim to explore the global spatial prevalence and temporal trends of the burden of low bone mineral density (LBMD) worldwide, due to a lack of related studies.DesignCross-sectional study.MethodsWe used data from the Global Burden of Disease Study 2019 to conduct this study. LBMD in the GBD study includes both osteopenia and osteoporosis. The estimation for the prevalence, measured by the summary exposure value (SEV), and burden of LBMD was made in DisMod-MR 2.1, a Bayesian meta-regression tool. Correlation analysis was performed using the Spearman rank order correlation methods. The temporal trends were represented by the estimated annual percentage change (EAPC).ResultsIn 2019, there were 438 thousand deaths and 16.6 million DALYs attributable to LBMD, increasing by 111.1% and 93.8% respectively, compared to that in 1990. From 1990 to 2019, the prevalence of LBMD has decreased worldwide, but has increased in high-income North America. Some countries, such as the United States, Australia, Canada, and China had increased disability and mortality rates of LBMD with time. Countries with low socio-demographic index (SDI) had higher incidence and mortality rate than those with high SDI. The prevalence of LBMD was lower in males, but the attributable disability and mortality were higher in males in all years from 1990 to 2019.ConclusionWith population aging, countries worldwide, especially those with low-SDI, will face increasing challenges in reducing the burden attributable to LBMD and osteoporosis. The treatment of osteoporosis has been overlooked in men for a long time. Effective measures are warranted to control the prevalence and burden of LBMD.

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“…Meta-analysis has demonstrated that the ability of TBS to predict osteoporotic fractures is comparable in men and women [ 15 ]. Since osteoporosis in men is often overlooked [ 33 , 34 ], the widespread implementation of TBS measurement in clinical practice may contribute to improved fracture risk assessment in all patients, including cirrhotic patients, regardless of sex.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of the Trabecular Bone Score in Assessing the Risk of Vertebral Fractures in Patients with Cirrhosis

Ogiso¹,

Hanai²,

Nishimura³

et al. 2022

JCM

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The trabecular bone score (TBS), a surrogate measure of bone microarchitecture, provides complementary information to bone mineral density (BMD) in the assessment of osteoporotic fracture risk. This cross-sectional study aimed to determine whether TBS can identify patients with liver cirrhosis that are at risk of vertebral fractures. We enrolled 275 patients who completed evaluations for lumbar BMD, TBS, and vertebral fractures between November 2018 and April 2021. BMD was measured using dual-energy X-ray absorptiometry (DXA), TBS was calculated by analyzing DXA images using TBS iNsight software, and vertebral fractures were evaluated using Genant’s semi-quantitative method with lateral X-ray images. Factors associated with vertebral fractures and their correlation with the TBS were identified using regression models. Of the enrolled patients, 128 (47%) were female, the mean age was 72 years, and 62 (23%) were diagnosed with vertebral fractures. The prevalence of vertebral fractures was higher in women than in men (33% vs. 14%; p < 0.001). The unadjusted odds ratio (OR) of the vertebral fractures for one standard deviation decrease in TBS and BMD was 2.14 (95% confidence interval [CI], 1.69–2.73) and 1.55 (95% CI, 1.26–1.90), respectively. After adjusting for age, sex, and BMD, the adjusted OR of the vertebral fractures in TBS was 2.26 (95% CI, 1.52–3.35). Multivariate linear regression analysis showed that TBS was independently correlated with age (β = −0.211), body mass index (β = −0.251), and BMD (β = 0.583). TBS can help identify patients with cirrhosis at risk of vertebral fractures.

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Osteoporosis: overlooked in men for too long

Cited by 23 publications

References 0 publications

Differences in the global exposure, mortality and disability of low bone mineral density between men and women: the underestimated burden in men

Differences in the global exposure, mortality and disability of low bone mineral density between men and women: the underestimated burden in men

Global, Regional, and National Burden of Low Bone Mineral Density From 1990 to 2019: Results From the Global Burden of Disease Study 2019

Usefulness of the Trabecular Bone Score in Assessing the Risk of Vertebral Fractures in Patients with Cirrhosis

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