Osteoporosis: Modern Paradigms for Last Century’s Bones

Kruger, Marlena C.; Wolber, Frances M.

doi:10.3390/nu8060376

Cited by 27 publications

(19 citation statements)

References 84 publications

(88 reference statements)

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“…NCKX3 in the basolateral membrane of intestinal tissue transports calcium to the blood, thus it has a key role in calcium absorption (41). Due to this function of NCKX3, abnormal expression of NCKX3 can induce decreased calcium absorption in the duodenum and calcium reabsorption in the kidney; furthermore, it may result in hypocalcemia and osteoporosis (42). In the present study, the results demonstrated that NCKX3 mRNA levels were high in the duodenum, spleen and kidney, and low in the liver.…”

Section: Discussionmentioning

confidence: 99%

Organ‑specific expression of the divalent ion channel proteins NCKX3, TRPV2, CTR1, ATP7A, IREG1 and HEPH in various canine organs

2018

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Transmembrane cation channels include those for calcium, copper and iron ion transport. Each channel has physiological significance, and all have been associated with disease. However, the comparative study of transcriptional‑translational levels in canine organs has not been previously reported. In the present study, organ‑specific expression of calcium channels, including sodium/potassium/calcium exchanger 3 (NCKX3) and transient receptor potential cation channel subfamily V member 2 (TRPV2), copper channels, including high affinity copper uptake protein 1 (CTR1) and copper‑transporting ATPase 1 (ATP7A), and iron channels, including iron‑regulated transporter 1 (IREG1) and hephaestin (HEPH) proteins and their mRNAs were examined in the canine duodenum, kidney, spleen and liver. NCKX3 protein expression was highest in the kidney, moderate in the duodenum, and lowest in the spleen and liver, whereas TRPV2 protein was highly expressed in the kidney, duodenum and liver, and was low in the spleen. The CTR1 protein expression level was highest in the liver, followed (in descending order) by the duodenum, kidney and spleen. The ATP7A protein expression level was highest in the duodenum and lowest in the spleen. The IREG1 protein expression level was highest in the liver, followed (in descending order) by the kidney, duodenum and spleen. The HEPH protein level was high in liver, moderate in the duodenum and kidney, and low in the spleen. The results of the immunohistochemistry analysis demonstrated ion channel protein localizations. These results suggested that cation channel proteins are differentially expressed among canine organs, and they may be involved in organ‑specific functions associated with the maintenance of physiological homeostasis.

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Section: Discussionmentioning

confidence: 99%

Organ‑specific expression of the divalent ion channel proteins NCKX3, TRPV2, CTR1, ATP7A, IREG1 and HEPH in various canine organs

2018

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“…Postmenopausal osteoporosis affects up to 200 million women world-wide with 70% of hip fractures occurring in women 52,53 . Osteoporotic fractures can lead to chronic pain, deformity, depression, disability, and death as well as having huge economic consequences.…”

Section: Menopause Vasomotor Symptoms and Osteoporosismentioning

confidence: 99%

“…In the UK alone, annual hospital costs associated with hip fractures are estimated to be £1.1 billion 54 . The prevention of fractures in postmenopausal women is, therefore, a vital public health priority worldwide 52,53 .…”

Section: Menopause Vasomotor Symptoms and Osteoporosismentioning

confidence: 99%

Vasomotor symptoms in menopause: a biomarker of cardiovascular disease risk and other chronic diseases?

Biglia¹,

Cagnacci

Gambacciani

et al. 2017

Climacteric

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Menopausal disorders may include shorter-term symptoms, such as hot flushes and night sweats (vasomotor symptoms, VMS) and longer-term chronic conditions such as cardiovascular disease (CVD), osteoporosis, and cognitive impairment. Initially, no clear link between the shorter-term symptoms and longer-term chronic conditions was evident and these disorders seemed to occur independently from each other. However, there is a growing body of evidence demonstrating that VMS may be a biomarker for chronic disease. In this review, the association between VMS and a range of chronic postmenopausal conditions including CVD, osteoporosis, and cognitive decline is discussed. Prevention of CVD in women, as for men, should be started early, and effective management of chronic disease in postmenopausal women has to start with the awareness that VMS during menopause are harbingers of things to come and should be treated accordingly.

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“…In addition to T2D, ethnic variation in BMD and fracture risk may relate to genetic, anthropometric, and lifestyle factors [7]. Being of First Nations (Aboriginal Canadian) ethnicity was among the predictors of fracture in an age, sex and region matched case control study in Canada [8].…”

Section: Introductionmentioning

confidence: 99%

Forearm bone density is not elevated in Inuit women with impaired fasting glucose or type 2 diabetes mellitus

Natour

Morin

Egeland

et al. 2019

International Journal of Circumpolar Health

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Bone mineral density (BMD) and fracture risk are elevated in adults with impaired fasting glucose (IFG) or type 2 diabetes mellitus (T2D). This study aimed to compare bone health among Inuit women with IFG, T2D and normoglycemia. The study included Inuit women (≥40 y) with IFG (n = 57), T2D (n = 72) or normoglycemia (n = 340) from the International Polar Year Inuit Health Survey 2007-2008 in Canada. Distal one-third forearm BMD (FaBMD) was measured using a peripheral instantaneous x-ray imager. Anthropometry, fasting plasma glucose (FPG), serum adiponectin, leptin and 25-hydroxyvitamin D (25(OH)D) were measured. Traditional food intakes were surveyed. Data were analysed using mixed model ANOVA and regression models. The median age was 53 (IFG: IQR 48, 67) y and 56 (T2D: IQR 49, 63) y. Compared to normoglycemic women, FaBMD and T-scores were significantly lower in women with T2D, but not with IFG. Frequency of marine mammal intakes (ß = 0.145; 95%CI: 0.018, 0.053, p = 0.0001) positively related to FaBMD. The odds ratio of having a T-score consistent with osteoporosis was lower among women with T2D and higher BMI, while aging increased the risk. Although T2D associates with lower BMD among Inuit women, risk of osteoporosis is tempered, possibly by maintenance of a traditional lifestyle.

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Osteoporosis: Modern Paradigms for Last Century’s Bones

Cited by 27 publications

References 84 publications

Organ‑specific expression of the divalent ion channel proteins NCKX3, TRPV2, CTR1, ATP7A, IREG1 and HEPH in various canine organs

Organ‑specific expression of the divalent ion channel proteins NCKX3, TRPV2, CTR1, ATP7A, IREG1 and HEPH in various canine organs

Vasomotor symptoms in menopause: a biomarker of cardiovascular disease risk and other chronic diseases?

Forearm bone density is not elevated in Inuit women with impaired fasting glucose or type 2 diabetes mellitus

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