Osteoporosis

Compston, Juliet; McClung, Michael R.; Leslie, William D.

doi:10.1016/s0140-6736(18)32112-3

Cited by 1,546 publications

(1,312 citation statements)

References 139 publications

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“…OA is usually regarded as a cartilage disease, but the pathological process includes changes in adjacent bone, synovium, ligaments, and tendons . OP is characterized by excessive bone resorption, micro architectural deterioration of bone tissue, and reduction in bone strength leads to an increase in fracture risk . Osteoporotic osteoarthritis (OPOA) is a special form of OA, and it is mainly associated with brittle subchondral bone and micro fracture, both of which accelerate OA progression .…”

Section: Introductionmentioning

confidence: 99%

“…ZHENG Et al. resorption, micro architectural deterioration of bone tissue, and reduction in bone strength leads to an increase in fracture risk. 3 Osteoporotic osteoarthritis (OPOA) is a special form of OA, and it is mainly associated with brittle subchondral bone and micro fracture, both of which accelerate OA progression. 4,5 So far, the relationship between OP and OA is not well understood.…”

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confidence: 99%

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Knee loading repairs osteoporotic osteoarthritis by relieving abnormal remodeling of subchondral bone via Wnt/β‐catenin signaling

Zheng

Ding

et al. 2020

FASEB j.

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Osteoporotic osteoarthritis (OPOA) is a common bone disease mostly in the elderly, but the relationship between Osteoporotic (OP) and osteoarthritis (OA) is complex. It has been shown that knee loading can mitigate OA symptoms. However, its effects on OPOA remain unclear. In this study, we characterized pathological linkage of OP to OA, and evaluated the effect of knee loading on OPOA. We employed two mouse models (OA and OPOA), and conducted histology, cytology, and molecular analyses. In the OA and OPOA groups, articular cartilage was degenerated and Osteoarthritis Research Society International score was increased. Subchondral bone underwent abnormal remodeling, the differentiation of bone marrow mesenchymal stem cells (BMSCs) to osteoblasts and chondrocytes was reduced, and migration and adhesion of pre‐osteoclasts were enhanced. Compared to the OA group, the pathological changes of OA in the OPOA group were considerably aggravated. After knee loading, however, cartilage degradation was effectively prevented, and the abnormal remodeling of subchondral bone was significantly inhibited. The differentiation of BMSCs was also improved, and the expression of Wnt/β‐catenin was elevated. Collectively, this study demonstrates that osteoporosis aggravates OA symptoms. Knee loading restores OPOA by regulating subchondral bone remodeling, and may provide an effective method for repairing OPOA.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Knee loading repairs osteoporotic osteoarthritis by relieving abnormal remodeling of subchondral bone via Wnt/β‐catenin signaling

Zheng

Ding

et al. 2020

FASEB j.

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“…This problem is handled by performing a regression directly on the cumulative dose, thus preserving the statistical power and in this study, proving a statistically significant dose‐response association. Since spinal fractures are usually spontaneous and notoriously related to osteoporosis, while traumas more often are involved in hip and wrist fractures, an isolated effect on spinal fractures is biologically plausible . Moreover, the increased susceptibility to glucocorticoid of trabecular bone predominating in the vertebral bone adds to the observed differences across fracture types…”

Section: Discussionmentioning

confidence: 99%

Long‐term oral budesonide treatment and risk of osteoporotic fractures in patients with microscopic colitis

Reilev

Hallas

Ernst

et al. 2020

Aliment Pharmacol Ther

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Summary Background Due to a substantial first‐pass metabolism of oral budesonide, systemic bioavailability is low compared to other oral corticosteroids, thereby possibly avoiding adverse effects of systemic corticosteroid use. Aim To determine whether use of oral budesonide is associated with osteoporotic fractures in patients with microscopic colitis (MC). Methods Applying data from the Danish nationwide health registries, we conducted a case‐control study nested within a cohort of patients with MC from 2004 to 2012. We estimated odds ratios (ORs) for the association between budesonide use and osteoporotic fractures (hip, wrist and spinal fractures). Results We identified 417 cases with a first occurrence of an osteoporotic fracture. Eighty‐six per cent were women and the median age was 78 years. The OR for the overall association between ever‐use of budesonide and any osteoporotic fractures did not reach statistical significance (OR 1.13, CI: 0.88‐1.47). The highest risk was observed for spinal fractures (OR 1.98, CI: 0.94‐4.17), where a dose‐response association seemed to exist, followed by hip and wrist fractures (OR 1.17 [CI: 0.79‐1.73] and OR 0.99 [CI: 0.66‐1.47] respectively). We generally found modestly increased ORs across subgroups at suspected high or low risk of fractures (1.00‐2.49). No overall dose‐response association was evident (OR for doubling of cumulative dose 0.93 (CI: 0.84‐1.03). Conclusion No overall association between use of oral budesonide and osteoporotic fractures was demonstrated among individuals with MC. There seemed to be an isolated adverse effect of budesonide on the risk of spinal fractures, which appears to be dose related.

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“…Osteoporosis is a common disease with an increasing prevalence in the aging population. 1,2 The influence of sex hormones on bone health has long been recognized. 3 Androgens have historically been accepted as pivotal steroids affecting the male skeleton, and the role of testosterone (T) deficiency in the development of osteoporosis in aging males has become a topic of growing interest.…”

Section: Introductionmentioning

confidence: 99%

Follicle‐stimulating hormone and estradiol are associated with bone mineral density and risk of fractures in men with type 2 diabetes mellitus

Jing

Wang

et al. 2019

Journal of Diabetes

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Background: Type 2 diabetes mellitus (T2DM) is associated with a higher fracture risk. Sex hormones are important for maintaining skeletal health. It is not clear which sex hormone(s) contribute(s) to bone mineral density (BMD) and fracture risk in males with T2DM. This study investigated the relationships of these parameters in males with T2DM. Methods: This study involved 482 men with T2DM. BMDs at the lumbar spine (L2-4), femoral neck (FN), and total hip (TH) were measured by dualenergy X-ray absorptiometry (DXA). The 10-year probability of fractures was assessed using the modified Fracture Risk Algorithm (FRAX) tool. Serum levels of sex hormones were measured. Results: Follicle-stimulating hormone (FSH) and estradiol (E2) were associated with BMDs at L2-4 (FSH, β = −.162, P < .05; E2, β = .176, P < .001), and E2 was associated with BMD at FN (β = .137, P < .05) and TH (β = .140, P < .05). FSH was associated with major osteoporotic fractures (β = .288, P < .001) and hip fractures (β = .235, P < .001). Higher FSH was a risk factor for osteoporosis/osteopenia (odds ratios [OR] = 2.92, 95% CI = 1.66-5.14, P < .001), whereas higher E2 was a protective factor (OR = 0.37, 95% CI = 0.22-0.60, P < .001). Patients in the higher tertile of FSH and lower tertile of E2 had an increased risk of osteoporosis/osteopenia (OR = 5.05, 95% CI = 1.37-18.65, P < .05).Conclusions: For males with T2DM, FSH and E2 are significantly associated with BMD, osteoporosis/osteopenia, and fracture risk. Highlights• Follicle-stimulating hormone (FSH) and estradiol (E2) were significantly associated with bone mineral density in male with type 2 diabetes mellitus (T2DM). • FSH was strongly associated with fracture risk measured by the modified Fracture Risk Algorithm (FRAX) tool in males with T2DM.

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Osteoporosis

Cited by 1,546 publications

References 139 publications

Knee loading repairs osteoporotic osteoarthritis by relieving abnormal remodeling of subchondral bone via Wnt/β‐catenin signaling

Knee loading repairs osteoporotic osteoarthritis by relieving abnormal remodeling of subchondral bone via Wnt/β‐catenin signaling

Long‐term oral budesonide treatment and risk of osteoporotic fractures in patients with microscopic colitis

Follicle‐stimulating hormone and estradiol are associated with bone mineral density and risk of fractures in men with type 2 diabetes mellitus

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