Osteoporosis influences the late period of fracture healing in a rat model prepared by ovariectomy and low calcium diet

Kubo, Toru; Shiga, Toshiki; Hashimoto, Jun; Yoshioka, Makoto; Honjo, Hideo; Urabe, Mamoru; Kitajima, Isao; Semba, Ichiro; Hirasawa, Yasusuke

doi:10.1016/s0960-0760(99)00032-1

Cited by 159 publications

(128 citation statements)

References 8 publications

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“…The histomorphometric analysis revealed that in the control group the ovariectomized animals achieved inferior bone regeneration than the normal rats, after 30 and 60 days. In many studies, ovariectomization of experimental animals has been associated with deficiencies in the bone regeneration process (30,31).…”

Section: Discussionmentioning

confidence: 99%

Effects of simvastatin on bone regeneration in the mandibles of ovariectomized rats and on blood cholesterol levels.

Junqueira

Mancini

Carvalho

et al. 2002

Journal of Oral Science

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Abstract:The purpose of this study was to evaluate the effects of simvastatin on guided bone regeneration in the mandibles of ovariectomized rats, and to observe their blood cholesterol levels. Seventy female rats were divided into two groups: control and treated, both groups containing normal and ovariectomized rats. A month after ovariectomy a bone defect was created in the mandible, and was covered by a polytetrafluoroethylene membrane. The treated groups received simvastatin orally for 15 or 30 days. The rats were sacrificed 15, 30 or 60 days after surgery, at which time a blood sample was extracted for blood cholesterol level analysis and the mandible was extracted for densitometric, histological and morphometric analysis. All specimens underwent analysis of variance. The ovariectomized animals had higher cholesterol levels than the treated normal animals, and no significant difference was found between the different treatment periods and the sacrifice times. The densitometric, histological and morphometric analysis showed that the treated ovariectomized animals developed more new bone than the control ovariectomized rats, but no significant difference was observed between the treatment periods. It can be concluded that the deficiency of estrogen increased the level of blood cholesterol and that the simvastatin aided new bone formation in the ovariectomized animals. (J. Oral Sci. 44, 117-124, 2002)

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Section: Discussionmentioning

confidence: 99%

Effects of simvastatin on bone regeneration in the mandibles of ovariectomized rats and on blood cholesterol levels.

Junqueira

Mancini

Carvalho

et al. 2002

Journal of Oral Science

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“…Experimental studies on fracture healing in rats have investigated the effect of osteoporosis and reported different findings [13]. Studies looking into long-term changes have shown few differences at early time points, but development of differences in the late periods of fracture healing when remodelling begins to occur [24,33,43].…”

Section: Discussionmentioning

confidence: 99%

“…They have coupled the decreased strength of fracture healing in osteoporotic bone to a finding of irregular formation of the trabeculae and less mineral acquisition [13,24,33,43]. Another factor found to influence the fusion mass negatively was smoking.…”

Section: Discussionmentioning

confidence: 99%

Fusion mass bone quality after uninstrumented spinal fusion in older patients

et al. 2010

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Older people are at increased risk of non-union after spinal fusion, but little is known about the factors determining the quality of the fusion mass in this patient group. The aim of this study was to investigate fusion mass bone quality after uninstrumented spinal fusion and to evaluate if it could be improved by additional direct current (DC) electrical stimulation. A multicenter RCT compared 40 and 100 lA DC stimulation with a control group of uninstrumented posterolateral fusion in patients older than 60 years. This report comprised 80 patients who underwent DEXA scanning at the 1 year follow-up. The study population consisted of 29 men with a mean age of 72 years (range 62-85) and 51 women with a mean age of 72 years (range 61-84). All patients underwent DEXA scanning of their fusion mass. Fusion rate was assessed at the 2 year follow-up using thin slice CT scanning. DC electrical stimulation did not improve fusion mass bone quality. Smokers had lower fusion mass BMD (0.447 g/cm 2 ) compared to non-smokers (0.517 g/cm 2 ) (P = 0.086). Women had lower fusion mass BMD (0.460 g/ cm 2 ) compared to men (0.552 g/cm 2 ) (P = 0.057). Using linear regression, fusion mass bone quality, measured as BMD, was significantly influenced by gender, age of the patient, bone density of the remaining part of the lumbar spine, amount of bone graft applied and smoking. Fusion rates in this cohort was 34% in the control group and 33 and 43% in the 40 and 100 lA groups, respectively (not significant). Patients classified as fused after 2 years had significant higher fusion mass BMD at 1 year (0.592 vs. 0.466 g/cm 2 , P = 0.0001). Fusion mass bone quality in older patients depends on several factors. Special attention should be given to women with manifest or borderline osteoporosis. Furthermore, bone graft materials with inductive potential might be considered for this patient population.

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“…[11][12][13][14]17,18,48,50 These results suggest that severe osteoporosis is probably not a contraindication to dental implant treatment and had no effect on the prognosis of the implants even in advanced implant therapy techniques. Furthermore the use of PRP in augmenting the severely atrophic posterior maxilla may have clinical benefits in terms of angiogenic properties and reducing the healing period of bone maturation, even in severe osteoporosis, accelerating the time of insertion of the implants.…”

Section: Discussionmentioning

confidence: 99%

“…After 6 weeks, healing was similar in test and control groups, whereas after 12 weeks newly generated bone in ovariectomized rats was osteoporotic and had low mineral density. 13 This finding may have wound healing implications for bone healing adjacent to dental implants, so the criteria for treatment using implants in patient with osteoporosis has been established to some extent by prolongation of the healing time. 14,15 Moreover, several studies have revealed no correlation between possible implant failure and the severity of osteoporosis.…”

mentioning

confidence: 99%

Management of atrophic maxilla in severe osteoporosis treated with bisphosphonates: a case report

Torres

Tamimi

García

et al. 2008

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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Osteoporosis influences the late period of fracture healing in a rat model prepared by ovariectomy and low calcium diet

Cited by 159 publications

References 8 publications

Effects of simvastatin on bone regeneration in the mandibles of ovariectomized rats and on blood cholesterol levels.

Effects of simvastatin on bone regeneration in the mandibles of ovariectomized rats and on blood cholesterol levels.

Fusion mass bone quality after uninstrumented spinal fusion in older patients

Management of atrophic maxilla in severe osteoporosis treated with bisphosphonates: a case report

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