Osteoporosis in patients with rheumatoid arthritis is associated with serum immune regulatory cellular factors

Qiu, Jianjun; Lu, Chunde; Zhang, Lei; Zhou, X. Y.; Zou, Hanlin

doi:10.1007/s10067-022-06212-0

Cited by 16 publications

(16 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

Section: Discussionmentioning

confidence: 99%

“…The ESR values of healthy individuals usually fluctuate within a relatively narrow range. However, the ESR is pathologically increased in patients with various inflammatory diseases, tuberculosis, rheumatic fever, tissue damage or necrosis, malignant tumors, rheumatoid arthritis, systemic lupus erythematosus, chronic nephritis, liver cirrhosis, multiple myeloma, giant cell arteritis, anemia, and even coronavirus disease of 2019 (COVID-19) ( 1 , 10 - 12 ). The ICSH recommends the Westergren method as the reference method for ESR detection, but it is time-consuming, requires a large amount of blood, is not easy to perform on a large scale, and has certain safety risks ( 13 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Performance evaluation of the BC-720 auto hematology analyzer and establishment of the reference intervals of erythrocyte sedimentation rate in healthy adults

Shu¹,

Ding²,

Ding³

et al. 2022

Ann Transl Med

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Performance evaluation of the BC-720 auto hematology analyzer and establishment of the reference intervals of erythrocyte sedimentation rate in healthy adults

Shu¹,

Ding²,

Ding³

et al. 2022

Ann Transl Med

View full text Add to dashboard Cite

show abstract

“…Nevertheless, in RA several alterations in systemic cytokine titers can be detected, which may influence bone remodeling and, consequently, the risk of osteoporotic fractures. In a recently published study, Qiu et al, determined disease activity and systemic cytokine levels in RA patients with and without osteoporosis [ 36 ]. Serum levels of TNF-α, IL-6, and IL-17 were higher and levels of IL-4 and IL-10 were lower in RA patients when compared to those without osteoporosis.…”

Section: Human Association Studiesmentioning

confidence: 99%

Mechanisms of Systemic Osteoporosis in Rheumatoid Arthritis

Pietschmann

Butylina

Kerschan‐Schindl

et al. 2022

IJMS

View full text Add to dashboard Cite

Rheumatoid arthritis (RA), an autoimmune disease, is characterized by the presence of symmetric polyarthritis predominantly of the small joints that leads to severe cartilage and bone destruction. Based on animal and human data, the pathophysiology of osteoporosis, a frequent comorbidity in conjunction with RA, was delineated. Autoimmune inflammatory processes, which lead to a systemic upregulation of inflammatory and osteoclastogenic cytokines, the production of autoantibodies, and Th cell senescence with a presumed disability to control the systemic immune system’s and osteoclastogenic status, may play important roles in the pathophysiology of osteoporosis in RA. Consequently, osteoclast activity increases, osteoblast function decreases and bone metabolic and mechanical properties deteriorate. Although a number of disease-modifying drugs to treat joint inflammation are available, data on the ability of these drugs to prevent fragility fractures are limited. Thus, specific treatment of osteoporosis should be considered in patients with RA and an associated increased risk of fragility fractures.

show abstract

“…IL-17 is a key inflammatory mediator in many diseases, such as autoimmunity, heart disease, and infection. In a study of rheumatoid arthritis (RA) (Qiu et al, 2022), it was found that IL17 combined with other cytokines can predict the incidence of osteoporosis complication in RA patients. Xu et al (Xu et al, 2021) showed that the combination of IL-17 and IL-6 had the highest diagnostic accuracy in predicting the prognosis of left ventricular diastolic dysfunction by ROC curve.…”

Section: Discussionmentioning

confidence: 99%

“…IL-17 is a key inflammatory mediator in many diseases, such as autoimmunity, heart disease, and infection. In a study of rheumatoid arthritis (RA) ( Qiu et al., 2022 ), it was found that IL17 combined with other cytokines can predict the incidence of osteoporosis complication in RA patients. Xu et al.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis values of Dectin-1 and IL-17 levels in plasma for invasive pulmonary aspergillosis in bronchiectasis

Li²,

Cao³

et al. 2022

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

BackgroundAmong immunocompetent patients, patients with bronchiectasis are considered to be a high-risk group for invasive pulmonary aspergillosis (IPA). Early diagnosis and treatment can improve the prognosis of patients.ObjectivesWe aimed to investigate the diagnostic value of Dectin-1 and IL-17 for diagnosing IPA with bronchiectasis.MethodsWe retrospectively collected data on patients with bronchiectasis who had been hospitalized in the Third Affiliated Hospital of Soochow University between September 2018 to December 2021. Dectin-1, IL-17 and GM were measured by enzyme-linked immunosorbent assays.ResultsA total of 129 patients were analyzed in the study, of whom 33 had proven or probable IPA with bronchiectasis. The remaining 96 patients served as controls. The plasma Dectin-1 and IL-17 levels in the IPA group were significantly higher than that in the control group (P=0.005; P<0.001). The plasma GM, BALF GM, plasma Dectin-1 and IL-17 assays had sensitivities of 39.4%, 62.5%, 69.7% and 78.8%, respectively, and specificities of 89.2%, 91.5%, 72.9% and 71.9%, respectively. The sensitivity of Dectin-1 and IL-17 in plasma was higher than that in plasma and BALF GM. while the specificity is lower than that of plasma and BALF GM. The diagnostic sensitivity and specificity of plasma GM combined with IL-17 for IPA in bronchiectasis were greater than 80%. The combination of plasma GM and IL-17 can improve the sensitivity of the GM test, but does not reduce the diagnostic specificity. The plasma Dectin-1 and IL-17 showed positive linear correlations with the bronchiectasis severity Index (BSI) score in linear regression.ConclusionsPlasma Dectin-1 and IL-17 levels were significantly higher in bronchiectasis patients with IPA. The sensitivity of Dectin-1 and IL-17 was superior to that of GM for the diagnosis of IPA in patients with bronchiectasis. The combination of GM and IL-17 in plasma is helpful for the diagnosis of IPA in bronchiectasis patients who cannot tolerate invasive procedures.

show abstract

Osteoporosis in patients with rheumatoid arthritis is associated with serum immune regulatory cellular factors

Cited by 16 publications

References 45 publications

Performance evaluation of the BC-720 auto hematology analyzer and establishment of the reference intervals of erythrocyte sedimentation rate in healthy adults

Performance evaluation of the BC-720 auto hematology analyzer and establishment of the reference intervals of erythrocyte sedimentation rate in healthy adults

Mechanisms of Systemic Osteoporosis in Rheumatoid Arthritis

Diagnosis values of Dectin-1 and IL-17 levels in plasma for invasive pulmonary aspergillosis in bronchiectasis

Contact Info

Product

Resources

About