Osteoporosis following solid organ transplantation

Vega, Damaris; Sakhaee, Khashayar

doi:10.2217/17460816.2.4.341

Cited by 1 publication

(2 citation statements)

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“…4). In most instances, immunosuppressive drugs have been suggested as a leading cause in the development of post-transplantation bone disease [13]. Despite this hypothesis, several bone histomorphometric studies in PRT patients have shown features, such as defective bone mineralization, which are uncharacteristic of steroid-induced osteoporosis [79, 80].…”

Section: Role Of Phosphorus Wasting In Post-renal Transplantation Bonmentioning

confidence: 99%

“…The pathophysiologic mechanism responsible for bone disease following solid organ transplantation has mainly been linked to the use of immunomodulatory agents [11–13]. However, PRT bone disease has its own specific presentation [10] since renal osteodystrophy is commonly encountered in patients with chronic kidney disease prior to transplantation.…”

Section: Introductionmentioning

confidence: 99%

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Post-renal transplantation hypophosphatemia

Sakhaee

2010

Pediatr Nephrol

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An understanding of the pathophysiologic mechanisms of post-renal transplant (PRT) bone disease is of important clinical significance. Although bone disease occurs after all solid organ transplantation, the cumulative skeletal fracture rate remains high in PRT subjects while reaching a plateau with other transplantations. One major difference in the pathophysiology of PRT bone disease is, perhaps, due to persistent renal phosphorus (Pi) wasting. Novel phosphaturic agents have recently been suggested to participate in the development of bone disease in PRT subjects. However, it is unclear as of yet whether these factors alone or in conjunction with excess parathyroid hormone (PTH) secretion play a key role in the development of negative Pi balance and consequent bone disease in this population. In this review, I present a natural history of PRT hypophosphatemia and persistent renal Pi leak, provide pathophysiologic insight into these developments, and discuss the difficulty in diagnosing these phenotypes in both adult and pediatric populations.

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Section: Role Of Phosphorus Wasting In Post-renal Transplantation Bonmentioning

confidence: 99%