Osteoporosis and vertebral fractures in ankylosing spondylitis

Davey-Ranasinghe, Nicole; Deodhar, Atul

doi:10.1097/bor.0b013e3283620777

Cited by 161 publications

(81 citation statements)

References 37 publications

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“…[6,7] Cooper et al [6] identified markedly increased relative risk of vertebral morphometric deformities in patients with AS compared with the control population. The review of recent literature on osteoporosis and vertebral fractures in AS published by DaveyÀRanasinghe and Deodhar [8] suggests that the prevalence of osteoporosis in AS patients is 25% and that of vertebral fractures is 10%. Both new bone formation and vertebral osteoporosis with its consequences might contribute to spinal pain, stiffness, loss of mobility and functional impairment in these patients.…”

Section: Introductionmentioning

confidence: 99%

Relationship between physical function, disease activity, spinal mobility and bone parameters (trabecular bone score and bone mineral density) in ankylosing spondylitis patients

Ivanova

Manolova

Boyadzhieva

et al. 2015

Biotechnology & Biotechnological Equipment

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(2015) Relationship between physical function, disease activity, spinal mobility and bone parameters (trabecular bone score and bone mineral density) in ankylosing spondylitis patients, Biotechnology & Biotechnological Equipment, 29:5, 956-962, DOI: 10.1080/13102818.2015 This study aimed to evaluate the relationship between physical function, disease activity, spinal mobility and bone parameters in ankylosing spondylitis (AS) patients. Fifty patients (27 men and 23 women) were examined. The clinical assessment included Bath AS Disease Activity Index, AS Disease Activity Score, Bath AS Functional Index, Bath AS Metrology Index (BASMI). Lumbar spine and femoral neck bone mineral density (BMD), spinal trabecular bone score (TBS) and the TBS T-score were calculated by dual-energy X-ray absorptiometry. Prevalence rates for osteoporosis and osteopaenia were 14% and 36%, respectively and for partially and fully degraded microarchitecture À 34% and 16%, respectively. A similar inverse correlation was observed between BASMI and TBS, TBS T-score and femoral BMD bone parameters, which were significantly lower in patients 45 years of age. No significant correlations were detected between any bone parameter and indicators of disease activity and physical function. Patients with a disease duration of 10 years tended to exhibit either normal or elevated spine BMD. Femoral BMD was lower in men. The higher BASMI was associated with an increased likelihood of TBS < 1.350 (odds ratio (OR) D 1.44, 1.05À1.97, p D 0.024) and TBS T-score < À1.00 (OR D 1.55, 1.11À2.16, p D 0.01). In summary, lumbar spine BMD can be erroneously influenced by osteoproliferation, unlike the TBS and TBS T-score. The limitations in spinal mobility predicted abnormal results for these two TBS parameters. TBS may be a better indicator of bone health than BMD in AS.

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Section: Introductionmentioning

confidence: 99%

Relationship between physical function, disease activity, spinal mobility and bone parameters (trabecular bone score and bone mineral density) in ankylosing spondylitis patients

Ivanova

Manolova

Boyadzhieva

et al. 2015

Biotechnology & Biotechnological Equipment

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“…More than 90% of Chinese AS patients are HLA-B27 positive, with the predominant subtype being HLA-B * 2704 (3). The axial spine and joints are most commonly affected in patients with AS; however, the disease also affects the heart, lungs, eyes, and colon, leading to complications such as uveitis (4), iridocyclitis (5), osteoporosis (6) and inflammatory bowel disease (7). Treatments for AS include non-steroidal anti-inflammatory drugs, tumor necrosis factor-alpha (TNF-α) inhibitors and physiotherapy to alleviate joint pain and stiffness.…”

Section: Introductionmentioning

confidence: 99%

Ankylosing spondylitis and the risk of cancer

Chang

Nguyễn

et al. 2017

Oncology Letters

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Abstract.Cancer is a multifactorial disease, and imbalances of the immune response and sex-associated features are considered risk factors for certain types of cancer. The present study aimed to assess whether ankylosing spondylitis (AS), an immune disorder that predominantly affects young adult men, is associated with an increased risk of cancer. Using the Taiwan National Health Insurance Research Database, a cohort of patients diagnosed with AS between 2000 and 2008 who had no history of cancer prior to enrollment was established (n=5,452). Age-and sex-matched patients without AS served as controls (n=21,808). The results revealed that the overall incidence of cancer was elevated in patients with AS [standardized incidence ratio (SIR), 1.15; 95% confidence interval (CI), 1.03-1.27]. AS carried an increased risk of hematological malignancy in both sexes, colon cancer in females and bone and prostate cancer in males. Young patients with AS (≤35 years) and patients with a Charlson comorbidity index (CCI) ≥2 experienced a higher incidence of cancer (males, SIR 1.92, and 95% CI 1.04-3.26; females, SIR 2.00 and 95% CI 1.46-5.50). The cancer risk was increased during the first 3 years following the diagnosis of AS (SIR 1.49, 95% CI 1.29-1.71), and overall cancer-free survival was significantly decreased in patients with AS patients of both sexes (P<0.0001). Therefore, AS was found to be associated with an increased risk of cancer. All AS patients must be screened for hematological malignancies, for prostate and bone cancer in males, and for colon cancer in females, particularly younger patients with a CCI ≥2.

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“…The prevalence of osteoporosis in individuals with AS is approximately 25% and vertebral fractures approximately 10%. Osteoporosis usually occurs after 10 years of AS disease 80 . Individuals with AS having a deficiency of vit D, have higher prevalence of osteoporosis instead of patients with normal status of 25(OH)D. Several studies have indicated the relative low status of 25(OH)D with the appearance of osteoporosis, and that vitamin D deficiency leads to osteoporosis through the promotion of inflammatory activity 62,64,81 .…”

Section: Vitamin D and Common Comorbidities In As Patientsmentioning

confidence: 99%

“…As mention patients with AS, frequently present increased rate of osteoporosis, poor quality of bones and vertebral fractures. Therefore, a screening of osteoporosis within a period of 10 years since the diagnosis is suggested and an assessment of the identified risk factors as well as the duration and activity of AS should also be considered 14,80 .…”

Section: Vitamin D and Common Comorbidities In As Patientsmentioning

confidence: 99%

Nutritional aspects and vitamin D supplementation in ankylosing spondylitis

Kalogeropoulou¹

2017

JRPMS

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Osteoporosis and vertebral fractures in ankylosing spondylitis

Cited by 161 publications

References 37 publications

Relationship between physical function, disease activity, spinal mobility and bone parameters (trabecular bone score and bone mineral density) in ankylosing spondylitis patients

Relationship between physical function, disease activity, spinal mobility and bone parameters (trabecular bone score and bone mineral density) in ankylosing spondylitis patients

Ankylosing spondylitis and the risk of cancer

Nutritional aspects and vitamin D supplementation in ankylosing spondylitis

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