Osteoporosis and osteonecrosis in systemic lupus erythematosus

Fernández‐Codina, Andreu; Pope, Janet

doi:10.1016/j.rcreu.2021.02.005

Cited by 2 publications

(1 citation statement)

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“…Furthermore, the in ammatory process impacts bone cell differentiation and function. In autoimmune diseases, in ammatory cell in ltration and mediator release hamper osteoblast bone-forming activity while promoting bone resorption, creating an imbalance in bone metabolism that culminates in osteoporosis and osteonecrosis [33]. But in the early stages of osteonecrosis caused by autoimmune diseases, optimal treatment often gets delayed owing to the di culty in diagnosing bone damage via standard X-rays.…”

Section: Discussionmentioning

confidence: 99%

Causal Relationship between Autoimmune Diseases and Risk of Osteonecrosis in European Population: A Two-Sample Mendelian Randomization Study

Lian,

Zhang,

Wang

et al. 2024

Preprint

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Background: Prior epidemiological and observational studies have identified a series of autoimmune diseases (ADs) linked with osteonecrosis (ON), although potential confounding variables have not been fully accounted for. Furthermore, comprehensive studies elucidating the causal relationship between autoimmune diseases and osteonecrosis are lacking. Objective: This research endeavored to clarify the causal relationship between a myriad of autoimmune diseases and ON through the application of a Mendelian randomization (MR) methodology. Methods: To explore the causal relationship between ADs and ON, Single Nucleotide Polymorphism (SNP) loci, firmly correlated with 12 autoimmune diseases including, but not limited to, type 1 diabetes mellitus (T1DM), rheumatoid arthritis (RA), ankylosing spondylitis (AS), and systemic lupus erythematosus (SLE), as well as osteonecrosis, were chosen as instrumental variables (IV). These were sourced from both the Finnish database (Finn-Gen) and the Genome-Wide Association Study (GWAS) public database. Various evaluation methods, such as inverse variance weighted (IVW), Simple Mode, MR-Egger, and weighted median and model, were employed to assess the causal relationship between 12 ADs and ON. Inverse variance weighted (IVW) is a widely utilized statistical method in genetic association studies for estimating and integrating genetic effects. It is particularly relevant for estimating single genetic effects across multiple genetic variant loci. Owing to its robust causal inference capabilities, IVW was employed as the primary analytical method in this MR study. For sensitivity analysis, MR-PRESSO, inverse variance weighted, MR-Egger, and a battery of other methods were utilized. Results: Post-MR analysis, IVW findings indicated that T1DM (OR=1.062; P=0.007), RA (OR=1.248; P=7.19×10-5), and AS (OR=8.50×1010; P=0.034) served as risk factors for osteonecrosis. Meanwhile, other autoimmune diseases such as myasthenia gravis (MG), Crohn's disease (CD), ulcerative colitis (UC), and psoriatic arthritis (PsA) did not exhibit a causal link with osteonecrosis. Additionally, the results of the reverse MR analysis failed to reveal any significant causal relationship between ON and ADs. Conclusion: This research substantiated that T1DM, AS, and RA are prominent risk factors for osteonecrosis in European Population, utilizing a two-sample MR approach for both directions.

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Section: Discussionmentioning

confidence: 99%