Osteoporosis and mandibles

Bozic, Marko; Hren, Nataša Ihan

doi:10.1259/dmfr/79749065

Cited by 38 publications

(11 citation statements)

References 19 publications

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“…2,[20][21][22] Osteoporosis is related to oral bone loss in animal studies on rats and it results in lower bone mineral density of women's mandibles. [1][2]7 In this study, when comparing with sham-operated group, serum E2 level in model group and experimental group decreased significantly, indicating ovariectomy was successful.…”

Section: Effect Of Enhanced Masticatory Force On Serum Biochemical Pasupporting

confidence: 48%

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Effect of enhanced masticatory force on OPG, RANKL and MGF in alveolar bone of ovariectomized rats

Sun

2020

J. Appl. Oral Sci.

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Menopause induces oral bone loss, leading to various oral diseases. Mastication importantly affects bone metabolism in the jawbone. Objective: To analyze the effect of enhanced masticatory force on osteoprotegerin (OPG), receptor activator of nuclear factor kappa B ligand (RANKL), and mechanogrowth factor (MGF) in alveolar bone of ovariectomized rats and to study the mechanics mechanism of the alveolar bone of ovariectomized rats response to enhanced masticatory force. Methodology: Thirty Sprague Dawley rats were randomly divided into three groups: sham-operation group (fat around the removed ovary + normal hard diet), model group (ovariectomy + normal hard diet), and experimental group (ovariectomy + high hard diet). It was a 2-month experiment. Enzyme-linked immunosorbent assay (ELISA) detected serum estradiol (E2), osteocalcin (BGP) and alkaline phosphatase (ALP) in rats. Bone histomorphometric indices in the third molar region of maxilla were detected by micro-CT; protein expressions of OPG, RANKL, and MGF in the third molar region of maxilla was detected by Western blot; and gene expression of OPG, RANKL, and MGF in the third molar region of maxilla was detected by Quantitative Real-Time PCR. Results: Comparing with model group, serum E2 in experimental group increased but not significantly, serum BGP and serum ALP in experimental group decreased but not significantly, OPG in experimental group in alveolar bone increased significantly, RANKL in experimental group in alveolar bone decreased significantly, RANKL/OPG ratio in experimental group decreased significantly, MGF in experimental group in alveolar bone increased significantly, bone volume to total volume fraction increased significantly in experimental group, trabecular thickness increased significantly in experimental group, and trabecular separation decreased significantly in experimental group. Conclusion: Enhanced masticatory force affected the expression of OPG, RANKL, and MGF in alveolar bone of ovariectomized rats, improved the quality of jaw bone of ovariectomized rats, and delayed oral bone loss by ovariectomy.

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Section: Effect Of Enhanced Masticatory Force On Serum Biochemical Pasupporting

confidence: 48%

“…Menopause results in oral bone loss, [1][2][3] which can lead to loose tooth, tooth loss, and periodontal disease. [2][3][4] Kribbs 5 (1990) found women with osteoporosis were three times more susceptible for teeth loss than their healthy controls.…”

Section: Introductionmentioning

confidence: 99%

Effect of enhanced masticatory force on OPG, RANKL and MGF in alveolar bone of ovariectomized rats

Sun

2020

J. Appl. Oral Sci.

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“…The reproductive age in female is over at the age of 45-50 when the menstruation cycle ends and sexual hormone rapidly decreases, well known as menopause 10. Estrogen deficiency plays a very important role on menopause as a cause of bone mass decrease 7.…”

Section: Discussionmentioning

confidence: 99%

Description of mandibular bone quality based on measurements of cortical thickness using Mental Index of male and female patients between 40-60 years old

2011

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Purpose : The purpose of this study was to obtain the description of the mandibular bone quality of male and female patients between 40-60 years old and their differences based on mandibular cortical bone thickness measured using Mental Index (MI). Materials and Methods : Forty digital panoramic radiographs, which consisted of twenty male and twenty female patients, 40-60 years old, were observed. Mandibular cortical bone thickness was measured using MI on both sides of the mandible. The average MI score of two groups were then assessed using t-sample independent test. Results : There were significant differences of mandibular bone quality based on mandibular cortical bone thickness measurement using MI between male and female patients (p⁄0.05). Conclusion : Mandibular bone quality based on cortical bone thickness measurement using MI of male and female patients indicated a significant difference. (Imaging Sci Dent 2011; 41 : 151-3)

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“… 18 12 Radiographic density measurements (pixel intensity): This may be measured as metal equivalent thickness (aluminum or copper 25 in most studies), optical density (light transmittance through an area of the radiograph), 26 the blackness of the radiograph, or as relative density between different areas. 9 10 Simple visual estimation: The cortex is classified qualitatively into 3 categories based on simple visual estimations of the mandibular inferior cortex width: normal, intermediate (medium), and very thin. It is evaluated by observing the site (the inferior border of the mandible) with the naked eye.…”

Section: Definitions Of the Dental Imaging-based Osteoporosis Screenimentioning

confidence: 99%

IDIOS: An innovative index for evaluating dental imaging-based osteoporosis screening indices

et al. 2016

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PurposeThe goal of this study was to develop a new index as an objective reference for evaluating current and newly developed indices used for osteoporosis screening based on dental images. Its name; IDIOS, stands for Index of Dental-imaging Indices of Osteoporosis Screening.Materials and MethodsA comprehensive PubMed search was conducted to retrieve studies on dental imaging-based indices for osteoporosis screening. The results of the eligible studies, along with other relevant criteria, were used to develop IDIOS, which has scores ranging from 0 (0%) to 15 (100%). The indices presented in the studies we included were then evaluated using IDIOS.ResultsThe 104 studies that were included utilized 24, 4, and 9 indices derived from panoramic, periapical, and computed tomographic/cone-beam computed tomographic techniques, respectively. The IDIOS scores for these indices ranged from 0 (0%) to 11.75 (78.32%).ConclusionIDIOS is a valuable reference index that facilitates the evaluation of other dental imaging-based osteoporosis screening indices. Furthermore, IDIOS can be utilized to evaluate the accuracy of newly developed indices.

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Osteoporosis and mandibles

Cited by 38 publications

References 19 publications

Effect of enhanced masticatory force on OPG, RANKL and MGF in alveolar bone of ovariectomized rats

Effect of enhanced masticatory force on OPG, RANKL and MGF in alveolar bone of ovariectomized rats

Description of mandibular bone quality based on measurements of cortical thickness using Mental Index of male and female patients between 40-60 years old

IDIOS: An innovative index for evaluating dental imaging-based osteoporosis screening indices

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