Osteoporosis and Bone Marrow Adipose Tissue

Beekman, Kerensa M.; Duque, Gustavo; Corsi, Alessandro; Tencerová, Michaela; Bisschop, Peter H.; Paccou, Julien

doi:10.1007/s11914-022-00768-1

Cited by 19 publications

(11 citation statements)

References 60 publications

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“…The pathophysiological mechanisms responsible for these bone health alterations in cases of weight loss are only partially understood, and in addition to the usual suspects (mechanical unloading, loss of lean mass, undernutrition, protein insufficiency, vitamin D, and calcium deficiency, etc.) [8][9][10][11][12][13], we need to better understand the involvement of unusual suspects, such as BMAT, given its presumed deleterious role in postmenopausal osteoporosis [15][16][17], diabetes-associated osteoporosis [76][77][78], and bone fragility in patients with chronic kidney disease [79][80][81].…”

Section: Discussionmentioning

confidence: 99%

“…Due to space constraints in this manuscript, we refer readers to other reviews on the same topic, which cover other BMAT imaging modalities, including dual-energy CT (DECT), 18F FDG-PET, and HRpQCT [17,27,29]. Dual-energy CT (DECT) and HRpQCT can be used to quantify BMAT and BMD at the same time.…”

Section: Non-invasive Measurement Of Bmat In Humansmentioning

confidence: 99%

“…It has been postulated that changes in bone marrow adipose tissue (BMAT), following weight loss in PwO, could contribute to adverse bone effects [15,16]. Indeed, recent reviews have emphasized the role of BMAT as a regulator of skeletal homeostasis [17,18]. However, the impact of dietary modifications and MBS on BMAT remains unclear, and the factors associated with changes in BMAT, as well as their association with bone metabolism, remain undetermined [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

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The Impact of Interventional Weight Loss on Bone Marrow Adipose Tissue in People Living with Obesity and Its Connection to Bone Metabolism

Tencerova,

Duque,

Beekman

et al. 2023

Nutrients

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This review focuses on providing physicians with insights into the complex relationship between bone marrow adipose tissue (BMAT) and bone health, in the context of weight loss through caloric restriction or metabolic and bariatric surgery (MBS), in people living with obesity (PwO). We summarize the complex relationship between BMAT and bone health, provide an overview of noninvasive imaging techniques to quantify human BMAT, and discuss clinical studies measuring BMAT in PwO before and after weight loss. The relationship between BMAT and bone is subject to variations based on factors such as age, sex, menopausal status, skeletal sites, nutritional status, and metabolic conditions. The Bone Marrow Adiposity Society (BMAS) recommends standardizing imaging protocols to increase comparability across studies and sites, they have identified both water–fat imaging (WFI) and spectroscopy (1H-MRS) as accepted standards for in vivo quantification of BMAT. Clinical studies measuring BMAT in PwO are limited and have shown contradictory results. However, BMAT tends to be higher in patients with the highest visceral adiposity, and inverse associations between BMAT and bone mineral density (BMD) have been consistently found in PwO. Furthermore, BMAT levels tend to decrease after caloric restriction-induced weight loss. Although weight loss was associated with overall fat loss, a reduction in BMAT did not always follow the changes in fat volume in other tissues. The effects of MBS on BMAT are not consistent among the studies, which is at least partly related to the differences in the study population, skeletal site, and duration of the follow-up. Overall, gastric bypass appears to decrease BMAT, particularly in patients with diabetes and postmenopausal women, whereas sleeve gastrectomy appears to increase BMAT. More research is necessary to evaluate changes in BMAT and its connection to bone metabolism, either in PwO or in cases of weight loss through caloric restriction or MBS, to better understand the role of BMAT in this context and determine the local or systemic factors involved.

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Section: Discussionmentioning

confidence: 99%

Section: Non-invasive Measurement Of Bmat In Humansmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Impact of Interventional Weight Loss on Bone Marrow Adipose Tissue in People Living with Obesity and Its Connection to Bone Metabolism

Tencerova,

Duque,

Beekman

et al. 2023

Nutrients

Self Cite

View full text Add to dashboard Cite

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“…Studies in ovariectomized mouse models have shown that estrogen deficiency leads to an increase in BMAs, which can be reversed by estrogen supplementation ( 89 ). Clinical research on osteoporosis has revealed that the age-related increase in BMAs is associated with bone loss, suggesting BMAs as negative regulators of bone mass ( 90 ). However, this correlation is not uniformly observed across studies.…”

Section: The Role Of Bmas In Lung Cancer Bone Metastasismentioning

confidence: 99%

Bone marrow adipocytes and lung cancer bone metastasis: unraveling the role of adipokines in the tumor microenvironment

Li,

Wu,

Xie

et al. 2024

Front. Oncol.

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Bone is a common site of metastasis for lung cancer. The “seed and soil” hypothesis suggests that the bone marrow microenvironment (“soil”) may provide a conducive survival environment for metastasizing tumor cells (“seeds”). The bone marrow microenvironment, comprising a complex array of cells, includes bone marrow adipocytes (BMAs), which constitute about 70% of the adult bone marrow volume and may play a significant role in tumor bone metastasis. BMAs can directly provide energy for tumor cells, promoting their proliferation and migration. Furthermore, BMAs participate in the tumor microenvironment’s osteogenesis regulation, osteoclast(OC) regulation, and immune response through the secretion of adipokines, cytokines, and inflammatory factors. However, the precise mechanisms of BMAs in lung cancer bone metastasis remain largely unclear. This review primarily explores the role of BMAs and their secreted adipokines (leptin, adiponectin, Nesfatin-1, Resistin, chemerin, visfatin) in lung cancer bone metastasis, aiming to provide new insights into the mechanisms and clinical treatment of lung cancer bone metastasis.

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“…White adipose tissues are organized into subcutaneous and visceral adipose tissues. In addition, pulmonary, gonadal, epicardial, perirenal and bone marrow-associated adipose tissues serve highly specific functions, which have been reviewed in detail [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Fecal and Urinary Adipokines as Disease Biomarkers

et al. 2023

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The use of biomarkers is of great clinical value for the diagnosis and prognosis of disease and the assessment of treatment efficacy. In this context, adipokines secreted from adipose tissue are of interest, as their elevated circulating levels are associated with a range of metabolic dysfunctions, inflammation, renal and hepatic diseases and cancers. In addition to serum, adipokines can also be detected in the urine and feces, and current experimental evidence on the analysis of fecal and urinary adipokine levels points to their potential as disease biomarkers. This includes increased urinary adiponectin, lipocalin-2, leptin and interleukin-6 (IL-6) levels in renal diseases and an association of elevated urinary chemerin as well as urinary and fecal lipocalin-2 levels with active inflammatory bowel diseases. Urinary IL-6 levels are also upregulated in rheumatoid arthritis and may become an early marker for kidney transplant rejection, while fecal IL-6 levels are increased in decompensated liver cirrhosis and acute gastroenteritis. In addition, galectin-3 levels in urine and stool may emerge as a biomarker for several cancers. With the analysis of urine and feces from patients being cost-efficient and non-invasive, the identification and utilization of adipokine levels as urinary and fecal biomarkers could become a great advantage for disease diagnosis and predicting treatment outcomes. This review article highlights data on the abundance of selected adipokines in urine and feces, underscoring their potential to serve as diagnostic and prognostic biomarkers.

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Osteoporosis and Bone Marrow Adipose Tissue

Cited by 19 publications

References 60 publications

The Impact of Interventional Weight Loss on Bone Marrow Adipose Tissue in People Living with Obesity and Its Connection to Bone Metabolism

The Impact of Interventional Weight Loss on Bone Marrow Adipose Tissue in People Living with Obesity and Its Connection to Bone Metabolism

Bone marrow adipocytes and lung cancer bone metastasis: unraveling the role of adipokines in the tumor microenvironment

Fecal and Urinary Adipokines as Disease Biomarkers

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