Osteoporosis and Bone Health in Transgender Individuals

Verroken, Charlotte; Collet, Sarah; Lapauw, Bruno; T’Sjoen, Guy

doi:10.1007/s00223-022-00972-2

Cited by 20 publications

(14 citation statements)

References 51 publications

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“…Zn is an important factor in bone health [ 197 ]. Although GAHT in adults has not shown major bone impacts, such treatments have recorded impaired bone development in adolescents [ 198 ]. However, whether such impairments occur through GAHT impacts on Zn uptake in transgender women is not yet known.…”

Section: Resultsmentioning

confidence: 99%

Zinc in Prostate Health and Disease: A Mini Review

Karunasinghe

2022

Biomedicines

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Introduction-With the high global prevalence of prostate cancer and associated mortalities, it is important to enhance current clinical practices for better prostate cancer outcomes. The current review is towards understanding the value of Zn towards this mission. Method-General information on Zn in biology and multiple aspects of Zn involvement in prostate health and disease were referred to in PubMed. Results-The most influential feature of Zn towards prostate health is its ability to retain sufficient citrate levels for a healthy prostate. Zn deficiencies were recorded in serum, hair, and prostate tissue of men with prostate cancer compared to non-cancer controls. Zn gut absorption, albumin binding, and storage compete with various factors. There are multiple associations of Zn cellular influx and efflux transporters, Zn finger proteins, matrix metalloproteinases, and Zn signaling with prostate cancer outcomes. Such Zn marker variations associated with prostate cancer recorded from biological matrices may improve algorithms for prostate cancer screening, prognosis, and management when coupled with standard clinical practices. Discussion-The influence of Zn in prostatic health and disease is multidimensional, therefore more personalized Zn requirements may be beneficial. Several opportunities exist to utilize and improve understanding of Zn associations with prostate health and disease.

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Section: Resultsmentioning

confidence: 99%

Zinc in Prostate Health and Disease: A Mini Review

Karunasinghe

2022

Biomedicines

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“…A prospective cohort study assessed BMD at set intervals after initiation of pubertal blockade found that z-scores decreased for the first two years after initiation of pubertal blockade [30 ▪ ]. Despite these risks, TGD adults on GAHT have parity in fracture risk with cisgender controls of their affirmed gender [33]. Additionally, GnRH agonists temporarily impair spermatogenesis and oocyte maturation while in use [13].…”

Section: Management Of Gender Dysphoriamentioning

confidence: 99%

Transgender and gender-diverse youth: an update on standard medical treatments for gender dysphoria and the sociopolitical climate

Arnold

McNamara

2023

Current Opinion in Pediatrics

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Purpose of review Transgender and gender-diverse (TGD) youth experience a discordance between their binary sex assigned at birth and gender identity. All TGD youth benefit from compassionate care delivered by clinicians who are informed in matters of gender diversity. Some of TGD youth experience clinically significant distress, termed gender dysphoria (GD), and may benefit from additional psychological support and medical treatments. Discrimination and stigma fuel minority stress in TGD youth and thus many struggle with mental health and psychosocial functioning. This review summarizes the current state of research on TGD youth and essential medical treatments for gender dysphoria. These concepts are highly relevant in the current sociopolitical climate. Pediatric providers of all disciplines are stakeholders in the care of TGD youth and should be aware of updates in this field. Recent findings Children who express gender-diverse identities continue to express these identities into adolescence. Medical treatments for GD have a positive effect on mental health, suicidality, psychosocial functioning, and body satisfaction. The overwhelming majority of TGD youth with gender dysphoria who receive medical aspects of gender affirming care continue these treatments into early adulthood. Political targeting and legal interference into social inclusion for TGD youth and medical treatments for GD are rooted in scientific misinformation and have negative impacts on their well being. Summary All youth-serving health professionals are likely to care for TGD youth. To provide optimal care, these professionals should remain apprised of best practices and understand basic principles of medical treatments for GD.

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“…Gender affirming treatment can impact BMD. In adolescents, GnRH agonists may decrease BMD and may compound the bone density loss induced by restriction [ 74 , 75 ]. Adolescence is a vulnerable time for BMD development as it represents the time of peak bone accrual.…”

Section: Additional Medical Considerationsmentioning

confidence: 99%

Medical considerations in the care of transgender and gender diverse patients with eating disorders

Riddle

Safer²

2022

J Eat Disord

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Transgender and gender diverse (TGD) individuals are at increased risk for the development of eating disorders, but very little has been published with regards to the unique aspects of their medical care in eating disorder treatment. Providing gender affirming care is a critical component of culturally competent eating disorder treatment. This includes knowledge of gender affirming medical and surgical interventions and how such interventions may be impacted by eating disordered behaviors, as well as the role of such interventions in eating disorder treatment and recovery. TGD individuals face barriers to care, and one of these can be provider knowledge. By better understanding these needs, clinicians can actively reduce barriers and ensure TGD individuals are provided with appropriate care. This review synthesizes the available literature regarding the medical care of TGD patients and those of patients with eating disorders and highlights areas for further research.

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Osteoporosis and Bone Health in Transgender Individuals

Cited by 20 publications

References 51 publications

Zinc in Prostate Health and Disease: A Mini Review

Zinc in Prostate Health and Disease: A Mini Review

Transgender and gender-diverse youth: an update on standard medical treatments for gender dysphoria and the sociopolitical climate

Medical considerations in the care of transgender and gender diverse patients with eating disorders

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