Osteoporose após transplante de órgãos sólidos

Cipriani, Rogerio; Farias, Maria Lúcia Fleiuss

doi:10.1590/s0004-27302005000300007

Cited by 6 publications

(10 citation statements)

References 63 publications

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“…Pre-clinical studies have shown that use of immunosuppressive drugs reduces bone density and also impairs healing of vascularized allografts and dental implant osseointegration (14,15). Also bone metabolism is significantly altered by chronic exposure to glucocorticoids, chronic exposure to glucocorticoids constituted the most common cause of secondary osteoporosis, mainly affecting trabecular bone (16).…”

Section: Discussionmentioning

confidence: 99%

Outcome of Implants in Kidney Transplant Patient Undergoing Immunosuppressive Therapy: Case Report

Cengiz¹,

Cengiz²,

Atalay³

et al. 2018

J Int Dent Sci

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Since the beginning of oral implant surgery, it has been recommended to exclude certain patients with systemic health problems from implant therapy. Although many studies have been done about the effect of systemic disease like diabetes and osteoporosis on implant success but there wasn't enough data about the effect of organ transplantation and immunosupresive therapy on implant success in the literature. As the success rate of organ transplantations increased, the number of patients on immunosupressive treatment increased. It has been reported in the literature that organ transplant patients undergoing immunosuppressive therapy may experience periodontal side-effects such as gingival overgrowth and implant failure. In our case 10 year of implant success was examined on the patient who are exposed to kidney transplantation 8 years ago and who takes cortisone and immunosupressive.

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Section: Discussionmentioning

confidence: 99%

Outcome of Implants in Kidney Transplant Patient Undergoing Immunosuppressive Therapy: Case Report

Cengiz¹,

Cengiz²,

Atalay³

et al. 2018

J Int Dent Sci

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“…4 Bone loss would be greater in the first 12 to 18 months of therapy and is directly related to the dose and duration of treatment. 9 Glucocorticoids have great effects on mineral homeostasis, and may stimulate parathyroid hormone (PTH) secretion both in a direct and an indirect manner. 9 Indirect increase results from diminished intestinal calcium absorption and increase in urinary calcium excretion.…”

Section: Literature Review Glucocorticoids (Gc)mentioning

confidence: 99%

“…9 Glucocorticoids have great effects on mineral homeostasis, and may stimulate parathyroid hormone (PTH) secretion both in a direct and an indirect manner. 9 Indirect increase results from diminished intestinal calcium absorption and increase in urinary calcium excretion. In the kidney, there is a reduction in calcium and phosphate tubular absorption.…”

Section: Literature Review Glucocorticoids (Gc)mentioning

confidence: 99%

“…11 Some of these medications are the immunosuppressants inhibitors of calcineurin-phosphatase (cyclosporin and tacrolimus), which are partly responsible for greater survival of transplanted patients and for the reduction in the glucocorticoids doses. However, similarly to the glucocorticoids, calcineurin-phosphatase inhibitors also cause reduction in bone mass, with the greatest bone loss occurring in the first 6 months after transplantation, when immunosuppressant therapy is most aggressive 9 . Even though the present tendency is to use a lower total dose of immunosuppressants, many transplanted patients continue to develop fractures as a complication.…”

Section: Introductionmentioning

confidence: 99%

“…1 The most frequently used immunosuppressants nowadays are those that affect cytokine synthesis (glucocorticoids, cyclosporin-CsA, tacrolimus-FK506, Sirolimus-RAPA) and those that affect nucleotide synthesis (azathioprine, Mycophenolate mofetil). 1 Over the last few years, with the growing use of immunosuppressants, questions have arisen about the action of these medications on bone metabolism 9 . The aim of this literature review is to inform the orthodontist about the influence of immunosuppressants on bony tissue and tooth movement.…”

Section: Introductionmentioning

confidence: 99%

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Immunosuppressants: implications in Orthodontics

Santos

Lacerda

Gonçalves

et al. 2012

Dental Press J. Orthod.

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INTRODUCTION: There are medications capable of affecting bone metabolism and the rate of tooth movement. Among these medications are the immunosuppressants, which act by repressing the action of T lymphocytes, however they can cause bone loss and consequently lead to osteoporosis. Osteoporosis is a common complication following kidney, heart, liver or lung transplantation. The immunosuppressant treatment for preventing organ rejection after transplantation, in general, includes glucocorticoids, cyclosporine, tacrolimus, and sirolimus. All these drugs can have jeopardizing effects on bone mineral homeostasis and consequently influence tooth movement. In recent years, however, the increasing use of immunosuppressants has raised questions about their effects on bone metabolism in patients undergoing orthodontic treatment. OBJECTIVE: The objective of this review study was to inform orthodontists about the influence of immunosuppressants on bone metabolism and tooth movement

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Iinfluence of the Immunosuppressant Tacrolimus (Fk-506) on the Flexural Strength of Femur: A Study in Rats

Pithon

Andrade

Rodrigues

et al. 2010

Revista Brasileira de Ortopedia (English Edition)

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Objective: To evaluate the resistance to femoral fractures among rats treated with the immunosuppressant tacrolimus FK-506 and compare these to untreated rats and rats treated with placebo. Methods: Ninety male Wistar rats were used. The animals were nine weeks old and weighed between 220 g and 280 g. The immunosuppressive agent tacrolimus was used in this study at a dose of 2 mg/kg/day, administered orally. The suspension was administered using an insulin syringe, and the maintenance therapeutic dose was sufficient to maintain the immunosuppressive activity. The animals were randomly divided into three groups (n = 30): group 1, no substance administered; group 2, administration of the immunosuppressant tacrolimus FK-506; and group 3, administration of the vehicle alone. Treatment with FK-506 was administered for 28 days. Total leukocyte counts and differential counts (lymphocytes, monocytes, eosinophils and neutrophils) were evaluated in order to monitor the immunosuppressive effect. Bone densitometry analysis by means of dual-energy x-ray absorptiometry (DXA) was also performed before and after administration of the drug. To evaluate the resistance to flexion, a support device was developed so that mechanical tests using an EMIC universal testing machine could be carried out. Results: The results from the flexion resistance tests showed statistical differences between groups 1 and 2 (p = 0.001) and between groups 2 and 3 (p = 0.001). No statistical difference was found between groups 1 and 3 (p = 0.995). Conclusions: The femurs of rats treated with the immunosuppressive agent had lower mechanical strength than did those of normal rats and those that received placebo.

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Osteoporose após transplante de órgãos sólidos

Cited by 6 publications

References 63 publications

Outcome of Implants in Kidney Transplant Patient Undergoing Immunosuppressive Therapy: Case Report

Outcome of Implants in Kidney Transplant Patient Undergoing Immunosuppressive Therapy: Case Report

Immunosuppressants: implications in Orthodontics

Iinfluence of the Immunosuppressant Tacrolimus (Fk-506) on the Flexural Strength of Femur: A Study in Rats

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